AR245711A1 - Procedimiento para obtener nuevos derivados del cromano. - Google Patents
Procedimiento para obtener nuevos derivados del cromano.Info
- Publication number
- AR245711A1 AR245711A1 AR90317525A AR31752590A AR245711A1 AR 245711 A1 AR245711 A1 AR 245711A1 AR 90317525 A AR90317525 A AR 90317525A AR 31752590 A AR31752590 A AR 31752590A AR 245711 A1 AR245711 A1 AR 245711A1
- Authority
- AR
- Argentina
- Prior art keywords
- oac
- oxo
- formula
- chroman
- cooa
- Prior art date
Links
- VZWXIQHBIQLMPN-UHFFFAOYSA-N chromane Chemical class C1=CC=C2CCCOC2=C1 VZWXIQHBIQLMPN-UHFFFAOYSA-N 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- GOWMBYUZXIZENX-CAUSLRQDSA-N 1-[(2r,3s,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-(hexadecylamino)pyrimidin-2-one Chemical compound O=C1N=C(NCCCCCCCCCCCCCCCC)C=CN1[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O1 GOWMBYUZXIZENX-CAUSLRQDSA-N 0.000 abstract 1
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
- MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical compound [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 abstract 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrane Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
PROCEDIMIENTO PARA OBTENER NUEVOS DERIVADOS DEL CROMANO, DE FORMULA (I), EN LA QUE R1 ES H O A; R2 ES F, CL, BR, I, OH, OA, OAC, SA, NO2, NH2, NHA, NA2, CN O COOA; R3 ES H, OH, OA O OAC; R4 ES H, Y TAMBIEN R3 JUNTO CON R4 SON UNA LIGADURA; R5 ES PIRIDILO, PIRIDAZINILO, PIRIMIDINILO, PIRAZINILO, OXO-DIHIDROPIRIDILO, OXO-DIHIDROPIRIDAZINILO, OXO-DIHIDROPIRIMIDINILO, OXO- DIHIDROPIRAZINILO,2-PIRROLIDINON-1-ILO O 3-OXO-CICLOPENTEN-1-ILO, SUSTITUIDO O NO UNA O DOS VECES CON A, F, CL, BR, I, OH, OAC, SH, NO2, NH2, NHAC, COOH Y/O COOA; R6 Y R7 SON H, A, OH, AO, CHO, ACO, ACS, HOOC, AOOC, AO-CS, ACOO, A-CS-O, HIDROXIALQUILO (C1-6), MERCAPTOALQUILO (C1-6), NO2, NH2, NHA, NA2, CN, F, CL, BR, I, CF3, ASO, ASO2, AO-SO, AO-SO2, ACNH, AO-CO NH, H2NSO, HANSO, A2NSO, H2NSO2, HANSO2, A2NSO2, H2NCO, HANCO, A2NCO, H2NCS, HANCS, A2NCS, ASONH, ASO2NH, AOSONH, AOSO2NH, ACO-ALQUILO (C1-6), NITROALQUILO (C1-6), CIANOALQUILO (C1-6), A-C(=NOH) O A-C(=NNH2);R8 ES H O A; Z ES O, S, NH O UNA LIGADURA; A ES ALQ UILO (C1-6), Y AC ES ALCANOILO(C1-8) O AROILO(C7-11), Y LAS SALES DE ESTOS COMPUESTOS; OBTENIDOS POR HACER REACCIONAR UN CROMANO DE FORMULA (II), EN LA QUE X-Y SON -EPOXI-R8O -CHE-CR3R8-, DONDE E ES CL, BR, I, O UN GRUPO DE OH ESTERIFICADO, REACTIVO, CON UN COMPUESTO DE FORMULA: R5-Z-H.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3926001A DE3926001A1 (de) | 1989-08-05 | 1989-08-05 | Chromanderivate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR245711A1 true AR245711A1 (es) | 1994-02-28 |
Family
ID=6386618
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AR90317525A AR245711A1 (es) | 1989-08-05 | 1990-08-03 | Procedimiento para obtener nuevos derivados del cromano. |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US5130322A (es) |
| EP (1) | EP0415065B1 (es) |
| JP (1) | JPH0366681A (es) |
| KR (1) | KR910004602A (es) |
| AR (1) | AR245711A1 (es) |
| AT (1) | ATE124407T1 (es) |
| AU (1) | AU623797B2 (es) |
| DE (2) | DE3926001A1 (es) |
| DK (1) | DK0415065T3 (es) |
| ES (1) | ES2073483T3 (es) |
| FI (1) | FI95700C (es) |
| HU (1) | HU213391B (es) |
| IE (1) | IE68313B1 (es) |
| IL (1) | IL95277A (es) |
| NO (1) | NO176477C (es) |
| NZ (1) | NZ234773A (es) |
| PT (1) | PT94902B (es) |
| TW (1) | TW209860B (es) |
| ZA (1) | ZA906144B (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5387587A (en) * | 1986-12-23 | 1995-02-07 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Chroman derivatives |
| US5284838A (en) * | 1987-06-23 | 1994-02-08 | Elf Sanofi | Use of 2,2-dimethylchroman-3-ol derivatives in the treatment of asthma |
| DE4102103A1 (de) * | 1991-01-25 | 1992-08-20 | Bayer Ag | Substituierte benzoxazepine und benzthiazepine, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln |
| KR950009863B1 (ko) * | 1991-05-22 | 1995-08-29 | 재단법인한국화학연구소 | 벤조피란 유도체와 그의 제조방법 |
| KR950009862B1 (ko) * | 1991-05-22 | 1995-08-29 | 재단법인한국화학연구소 | 벤조피란 유도체와 그의 제조방법(1) |
| CA2070243A1 (en) * | 1991-06-14 | 1992-12-15 | Akira Shiozawa | Chroman derivatives |
| US5250547A (en) * | 1991-08-29 | 1993-10-05 | Syntex (U.S.A.) Inc. | Benzopyran derivatives |
| US5719155A (en) * | 1993-11-10 | 1998-02-17 | Japan Tobacco Inc. | Chroman derivative and pharmaceutical use thereof |
| US5470861A (en) * | 1994-08-04 | 1995-11-28 | Hoffmann-La Roche Inc. | Method of promoting hair growth |
| DE19647000A1 (de) * | 1996-11-14 | 1998-05-20 | Hoechst Ag | 3-Amido-chromanylsulfonyl(thio)harnstoffe, Verfahren zu ihrer Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
| JP2001151767A (ja) * | 1999-09-17 | 2001-06-05 | Nissan Chem Ind Ltd | ベンゾピラン誘導体 |
| JP2001158780A (ja) * | 1999-09-24 | 2001-06-12 | Nissan Chem Ind Ltd | ４−オキシベンゾピラン誘導体 |
| JP2001172275A (ja) * | 1999-10-05 | 2001-06-26 | Nissan Chem Ind Ltd | ４−オキシベンゾピラン誘導体 |
| WO2011013987A2 (ko) * | 2009-07-29 | 2011-02-03 | 한국화학연구원 | 2,2-이치환-2h-크로멘 화합물 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3274350D1 (en) * | 1981-09-25 | 1987-01-08 | Beecham Group Plc | Pharmaceutically active benzopyran compounds |
| EP0091748B1 (en) * | 1982-04-08 | 1986-06-18 | Beecham Group Plc | Antihypertensive benzopyranols |
| EP0093534A1 (en) * | 1982-04-28 | 1983-11-09 | Beecham Group Plc | Novel chromanols |
| ATE56007T1 (de) * | 1984-06-22 | 1990-09-15 | Beecham Group Plc | Wirksame benzopyranverbindungen. |
| GB8419515D0 (en) * | 1984-07-31 | 1984-09-05 | Beecham Group Plc | Treatment |
| GB8419516D0 (en) * | 1984-07-31 | 1984-09-05 | Beecham Group Plc | Treatment |
| PT84806B (pt) * | 1986-05-03 | 1989-12-29 | Beecham Group Plc | Processo para a preparacao de benzopiranos |
| DE3726261A1 (de) * | 1986-12-23 | 1988-07-07 | Merck Patent Gmbh | Chromanderivate |
| CH674984A5 (es) * | 1987-05-16 | 1990-08-15 | Sandoz Ag | |
| IL86798A (en) * | 1987-06-23 | 1992-12-01 | Sanofi Sa | 2,2-dimethylchroman-3-ol derivatives, their preparation and pharmaceutical compositions containing them |
| AU618007B2 (en) * | 1987-06-23 | 1991-12-12 | Sanofi | 2,2-dimethylchroman-3-ol derivatives, process for their preparation and pharmaceutical compositions in which they are present |
| US4971982A (en) * | 1987-07-06 | 1990-11-20 | Hoffmann-La Roche Inc. | Benzopyran derivatives |
-
1989
- 1989-08-05 DE DE3926001A patent/DE3926001A1/de not_active Withdrawn
-
1990
- 1990-07-21 DE DE59009322T patent/DE59009322D1/de not_active Expired - Fee Related
- 1990-07-21 AT AT90114008T patent/ATE124407T1/de not_active IP Right Cessation
- 1990-07-21 DK DK90114008.7T patent/DK0415065T3/da active
- 1990-07-21 EP EP90114008A patent/EP0415065B1/de not_active Expired - Lifetime
- 1990-07-21 ES ES90114008T patent/ES2073483T3/es not_active Expired - Lifetime
- 1990-08-02 AU AU60134/90A patent/AU623797B2/en not_active Ceased
- 1990-08-02 KR KR1019900011867A patent/KR910004602A/ko not_active Ceased
- 1990-08-02 TW TW079106412A patent/TW209860B/zh active
- 1990-08-03 JP JP2205312A patent/JPH0366681A/ja active Pending
- 1990-08-03 ZA ZA906144A patent/ZA906144B/xx unknown
- 1990-08-03 NZ NZ234773A patent/NZ234773A/en unknown
- 1990-08-03 NO NO903431A patent/NO176477C/no unknown
- 1990-08-03 AR AR90317525A patent/AR245711A1/es active
- 1990-08-03 US US07/562,542 patent/US5130322A/en not_active Expired - Fee Related
- 1990-08-03 IE IE282290A patent/IE68313B1/en not_active IP Right Cessation
- 1990-08-03 PT PT94902A patent/PT94902B/pt not_active IP Right Cessation
- 1990-08-03 HU HU904889A patent/HU213391B/hu unknown
- 1990-08-03 FI FI903863A patent/FI95700C/fi not_active IP Right Cessation
- 1990-08-03 IL IL9527790A patent/IL95277A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ES2073483T3 (es) | 1995-08-16 |
| IE68313B1 (en) | 1996-06-12 |
| FI95700C (fi) | 1996-03-11 |
| HUT58713A (en) | 1992-03-30 |
| NO903431L (no) | 1991-02-06 |
| DE59009322D1 (de) | 1995-08-03 |
| IL95277A0 (en) | 1991-06-30 |
| IE902822A1 (en) | 1991-02-27 |
| US5130322A (en) | 1992-07-14 |
| DK0415065T3 (da) | 1995-08-28 |
| PT94902B (pt) | 1997-06-30 |
| HU213391B (en) | 1997-06-30 |
| ZA906144B (en) | 1991-05-29 |
| NZ234773A (en) | 1992-10-28 |
| AU6013490A (en) | 1991-02-07 |
| NO176477B (no) | 1995-01-02 |
| FI95700B (fi) | 1995-11-30 |
| FI903863A0 (fi) | 1990-08-03 |
| KR910004602A (ko) | 1991-03-29 |
| NO176477C (no) | 1995-04-12 |
| DE3926001A1 (de) | 1991-02-07 |
| HU904889D0 (en) | 1991-01-28 |
| EP0415065B1 (de) | 1995-06-28 |
| PT94902A (pt) | 1991-04-18 |
| IL95277A (en) | 1995-10-31 |
| JPH0366681A (ja) | 1991-03-22 |
| TW209860B (es) | 1993-07-21 |
| EP0415065A1 (de) | 1991-03-06 |
| NO903431D0 (no) | 1990-08-03 |
| ATE124407T1 (de) | 1995-07-15 |
| AU623797B2 (en) | 1992-05-21 |
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