AR245455A1 - Procedimiento para la obtencion de derivados de heparina,parcial o totalmente n-acetilados en el resto glucosaminico y productos asi obtenidos excluidos sus usos farmaceuticos. - Google Patents
Procedimiento para la obtencion de derivados de heparina,parcial o totalmente n-acetilados en el resto glucosaminico y productos asi obtenidos excluidos sus usos farmaceuticos.Info
- Publication number
- AR245455A1 AR245455A1 AR89314703A AR31470389A AR245455A1 AR 245455 A1 AR245455 A1 AR 245455A1 AR 89314703 A AR89314703 A AR 89314703A AR 31470389 A AR31470389 A AR 31470389A AR 245455 A1 AR245455 A1 AR 245455A1
- Authority
- AR
- Argentina
- Prior art keywords
- acetylated
- totally
- procedure
- partially
- glucosaminic
- Prior art date
Links
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 title abstract 4
- 229920000669 heparin Polymers 0.000 title abstract 3
- 229960002897 heparin Drugs 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 2
- MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 abstract 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
- TUCNEACPLKLKNU-UHFFFAOYSA-N acetyl Chemical compound C[C]=O TUCNEACPLKLKNU-UHFFFAOYSA-N 0.000 abstract 1
- 150000008064 anhydrides Chemical class 0.000 abstract 1
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 abstract 1
- 239000011575 calcium Substances 0.000 abstract 1
- 229910052791 calcium Inorganic materials 0.000 abstract 1
- 229960002442 glucosamine Drugs 0.000 abstract 1
- 239000002628 heparin derivative Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Materials Engineering (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
UN PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE HEPARINA, PARCIAL O TOTALMENTE N-ACETILADOS EN EL RESTO GLUCOSAMINICO DE LA MOLECULA DE HEPARINA, EFECTUANDO LAS ETAPAS DE: A) HIDROLIZAR SELECTIVAMENTE LOS GRUPOS N-SULFATO PRESENTES ORIGINARIAMENTE EN EL RESTO GLUCOSAMINICO DE LA HEPARINA, MEDIANTE LA REACCION DE HEPARINATO CALCICO CON ACIDO CLORHIDRICO ACUOSO EN CONCENTRACION 0,25 M,DETENIENDO LA REACCION POR AJUSTE A PH 7 CON SOLUCION DE HIDROXIDO DE SODIO, Y B) ACETILAR SELECTIVAMENTE LOS GRUPOS - NH2 LIBRES GENERADOS EN LA ETAPA (A) POR REACCION CON ANHIDRIDO ACETICO EN CANTIDAD ESTEQUIOMETRICA DE 1- 1,1 MOLES DE (CH3CO)2O POR MOL DE GLUCOSAMINA N-DESULFATADA) A UN PH COMPRENDIDO ENTRE 9,3 - 9,5 A UNA TEMPERATURA DE 25*C.
Priority Applications (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AR89314703A AR245455A1 (es) | 1989-08-18 | 1989-08-18 | Procedimiento para la obtencion de derivados de heparina,parcial o totalmente n-acetilados en el resto glucosaminico y productos asi obtenidos excluidos sus usos farmaceuticos. |
| ES90115227T ES2053415T3 (es) | 1989-08-18 | 1990-08-08 | Substancias con estructura tipo heparina y su metodo de produccion. |
| DE69016127T DE69016127T2 (de) | 1989-08-18 | 1990-08-08 | Substanzen mit heparinähnlicher Struktur und Verfahren zu deren Herstellung. |
| EP90115227A EP0413248B1 (en) | 1989-08-18 | 1990-08-08 | Substances with heparin-like structure and their method of production |
| DE199090115227T DE413248T1 (de) | 1989-08-18 | 1990-08-08 | Substanzen mit heparinaehnlicher struktur und verfahren zur herstellung. |
| AT90115227T ATE117321T1 (de) | 1989-08-18 | 1990-08-08 | Substanzen mit heparinähnlicher struktur und verfahren zu deren herstellung. |
| JP2215942A JPH03185001A (ja) | 1989-08-18 | 1990-08-17 | ヘパリンのｎ―アセチル化物及びその製造方法 |
| KR1019900012641A KR0155166B1 (ko) | 1989-08-18 | 1990-08-17 | 헤파린상 구조를 지닌 물질 및 이의 제조방법 |
| US07/946,034 US5340932A (en) | 1989-08-18 | 1992-09-16 | Substances with heparin-like structure and their method of production |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AR89314703A AR245455A1 (es) | 1989-08-18 | 1989-08-18 | Procedimiento para la obtencion de derivados de heparina,parcial o totalmente n-acetilados en el resto glucosaminico y productos asi obtenidos excluidos sus usos farmaceuticos. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR245455A1 true AR245455A1 (es) | 1994-01-31 |
Family
ID=3478715
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AR89314703A AR245455A1 (es) | 1989-08-18 | 1989-08-18 | Procedimiento para la obtencion de derivados de heparina,parcial o totalmente n-acetilados en el resto glucosaminico y productos asi obtenidos excluidos sus usos farmaceuticos. |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP0413248B1 (es) |
| JP (1) | JPH03185001A (es) |
| KR (1) | KR0155166B1 (es) |
| AR (1) | AR245455A1 (es) |
| AT (1) | ATE117321T1 (es) |
| DE (2) | DE69016127T2 (es) |
| ES (1) | ES2053415T3 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5696100A (en) * | 1992-12-22 | 1997-12-09 | Glycomed Incorporated | Method for controlling O-desulfation of heparin and compositions produced thereby |
| US5296471A (en) * | 1992-12-22 | 1994-03-22 | Glycomed Incorporated | Method for controlling o-desulfation of heparin and compositions produced thereby |
| DE69535565T2 (de) * | 1994-07-01 | 2008-05-08 | Seikagaku Corp. | Verwendung von desulfatiertem Heparin |
| DE50213462D1 (de) | 2001-10-15 | 2009-05-28 | Hemoteq Ag | Beschichtung von stents zur verhinderung von restenose |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1169888B (it) * | 1983-10-25 | 1987-06-03 | Italfarmaco Spa | Glicosaminoglicani modificati dotati di attivita' antitrombotica |
| DE3422518A1 (de) * | 1984-06-16 | 1985-12-19 | B. Braun Melsungen Ag, 3508 Melsungen | Heparin-derivate, verfahren zu ihrer herstellung, diese enthaltende arzneimittel und ihre verwendung bei der behandlung von fettstoffwechselstoerungen |
| WO1988001280A1 (en) * | 1986-08-21 | 1988-02-25 | Board Of Regents, The University Of Texas System | Glycosaminoglycan derivatives and their use as inhibitors of tumor invasiveness or metastatic profusion |
-
1989
- 1989-08-18 AR AR89314703A patent/AR245455A1/es active
-
1990
- 1990-08-08 DE DE69016127T patent/DE69016127T2/de not_active Expired - Fee Related
- 1990-08-08 AT AT90115227T patent/ATE117321T1/de not_active IP Right Cessation
- 1990-08-08 ES ES90115227T patent/ES2053415T3/es not_active Expired - Lifetime
- 1990-08-08 EP EP90115227A patent/EP0413248B1/en not_active Expired - Lifetime
- 1990-08-08 DE DE199090115227T patent/DE413248T1/de active Pending
- 1990-08-17 KR KR1019900012641A patent/KR0155166B1/ko not_active Expired - Fee Related
- 1990-08-17 JP JP2215942A patent/JPH03185001A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP0413248A1 (en) | 1991-02-20 |
| ES2053415T3 (es) | 1995-05-16 |
| DE69016127T2 (de) | 1995-05-18 |
| DE69016127D1 (de) | 1995-03-02 |
| ES2053415T1 (es) | 1994-08-01 |
| KR910004668A (ko) | 1991-03-29 |
| DE413248T1 (de) | 1993-06-09 |
| ATE117321T1 (de) | 1995-02-15 |
| EP0413248B1 (en) | 1995-01-18 |
| JPH03185001A (ja) | 1991-08-13 |
| KR0155166B1 (ko) | 1998-10-15 |
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