[go: up one dir, main page]

AR229435A1 - Procedimiento para preparar 1,4-dihidro-2,6-dimetil-1-(2-(4-morfolinil)-etil)-4-(2-trifluorometil)-fenil)-3,5-piridindicarboxilato de dietilo,util como antihipertensivo - Google Patents

Procedimiento para preparar 1,4-dihidro-2,6-dimetil-1-(2-(4-morfolinil)-etil)-4-(2-trifluorometil)-fenil)-3,5-piridindicarboxilato de dietilo,util como antihipertensivo

Info

Publication number
AR229435A1
AR229435A1 AR290756A AR29075682A AR229435A1 AR 229435 A1 AR229435 A1 AR 229435A1 AR 290756 A AR290756 A AR 290756A AR 29075682 A AR29075682 A AR 29075682A AR 229435 A1 AR229435 A1 AR 229435A1
Authority
AR
Argentina
Prior art keywords
piridindicarboxylate
hypertensive
morpholinyl
dihydro
trifluoromethyl
Prior art date
Application number
AR290756A
Other languages
English (en)
Original Assignee
Usv Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Usv Pharma Corp filed Critical Usv Pharma Corp
Application granted granted Critical
Publication of AR229435A1 publication Critical patent/AR229435A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
AR290756A 1980-04-11 1982-09-24 Procedimiento para preparar 1,4-dihidro-2,6-dimetil-1-(2-(4-morfolinil)-etil)-4-(2-trifluorometil)-fenil)-3,5-piridindicarboxilato de dietilo,util como antihipertensivo AR229435A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/139,367 US4258042A (en) 1980-04-11 1980-04-11 Antihypertensive pyridines and compositions

Publications (1)

Publication Number Publication Date
AR229435A1 true AR229435A1 (es) 1983-08-15

Family

ID=22486280

Family Applications (2)

Application Number Title Priority Date Filing Date
AR284913A AR227306A1 (es) 1980-04-11 1981-04-09 Un procedimiento para preparar 1,4-dihidro-2,6-dimetil-1-(2-4(morfolinil)-etil)-4-(2-(trifluorometil)fenil)-3,5-piridincarboxilato de dietilo,util como antihipertensivo
AR290756A AR229435A1 (es) 1980-04-11 1982-09-24 Procedimiento para preparar 1,4-dihidro-2,6-dimetil-1-(2-(4-morfolinil)-etil)-4-(2-trifluorometil)-fenil)-3,5-piridindicarboxilato de dietilo,util como antihipertensivo

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AR284913A AR227306A1 (es) 1980-04-11 1981-04-09 Un procedimiento para preparar 1,4-dihidro-2,6-dimetil-1-(2-4(morfolinil)-etil)-4-(2-(trifluorometil)fenil)-3,5-piridincarboxilato de dietilo,util como antihipertensivo

Country Status (23)

Country Link
US (1) US4258042A (es)
JP (1) JPS56158762A (es)
AR (2) AR227306A1 (es)
AU (1) AU6941181A (es)
BE (1) BE888327A (es)
CA (1) CA1175825A (es)
CH (1) CH647519A5 (es)
DE (1) DE3109794A1 (es)
DK (1) DK162581A (es)
ES (1) ES8202001A1 (es)
FI (1) FI810981L (es)
FR (1) FR2480284A1 (es)
GB (1) GB2073739B (es)
IL (1) IL62362A (es)
IT (1) IT1137539B (es)
LU (1) LU83293A1 (es)
NL (1) NL8100745A (es)
NO (1) NO811240L (es)
NZ (1) NZ196787A (es)
PH (1) PH15278A (es)
SE (1) SE8101211L (es)
ZA (1) ZA81802B (es)
ZW (1) ZW8281A1 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3208628A1 (de) * 1982-03-10 1983-09-22 Bayer Ag, 5090 Leverkusen Neue verbindungen, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
US4656181A (en) * 1982-11-24 1987-04-07 Cermol S.A. Esters of 1,4-dihydropyridines, processes for the preparation of the new esters, and medicaments containing the same
US4435395A (en) 1983-03-03 1984-03-06 Usv Pharmaceutical Corporation N-Substituted 1,4-dihydropyridazines and pharmaceutical compositions
US4491582A (en) * 1983-03-03 1985-01-01 Usv Pharmaceutical Corporation N-(substituted piperazino)-1,4-dihydropyridine-3,5-carboxylic acid
US4500528A (en) * 1983-03-03 1985-02-19 Usv Pharmaceutical Corporation N-Substituted 1,4-dihydropyridines and pharmaceutical compositions
US4503223A (en) * 1983-08-11 1985-03-05 Usv Pharmaceutical Corporation Process for the purification of N-morpholinoalkyl dihydropyridines
IE57810B1 (en) * 1984-03-27 1993-04-21 Delagrange Lab 1,4-dihydropyridine derivatives,their preparation and their use
US4757071A (en) * 1984-12-14 1988-07-12 Nisshin Flour Milling Co., Ltd. 1,4-dihydropyridine derivatives, and pharmaceutical compositions containing same, useful for treating cardiovascular diseases
US4833150A (en) * 1985-03-14 1989-05-23 Nelson Research & Development Co. 1,4-dihydropyridines
US4659717A (en) * 1985-08-21 1987-04-21 Eli Lilly And Company Dihydropyridines useful in the treatment of angina and stroke
DE3544211A1 (de) * 1985-12-13 1987-06-19 Bayer Ag Neue, fluorhaltige 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
US4780538A (en) * 1986-02-12 1988-10-25 Merck & Co., Inc. Process for 1,4-dihydropyridine compounds using a titanamine catalyst
US4849436A (en) * 1986-03-11 1989-07-18 Nelson Research & Development Co. 1,4-dihydropyridines

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5170767A (en) * 1974-12-17 1976-06-18 Yamanouchi Pharma Co Ltd Shinki nn chikan 1*44 jihidoropirijinjudotaino goseiho

Also Published As

Publication number Publication date
FI810981A7 (fi) 1981-10-12
FR2480284B1 (es) 1984-01-06
SE8101211L (sv) 1981-10-12
FR2480284A1 (fr) 1981-10-16
GB2073739B (en) 1984-07-11
CA1175825A (en) 1984-10-09
ES499667A0 (es) 1982-02-01
ES8202001A1 (es) 1982-02-01
LU83293A1 (fr) 1981-12-02
NL8100745A (nl) 1981-11-02
NZ196787A (en) 1984-04-27
BE888327A (fr) 1981-10-08
ZA81802B (en) 1982-02-24
JPS56158762A (en) 1981-12-07
PH15278A (en) 1982-11-02
IT8121078A0 (it) 1981-04-10
AR227306A1 (es) 1982-10-15
GB2073739A (en) 1981-10-21
ZW8281A1 (en) 1981-07-01
IT1137539B (it) 1986-09-10
US4258042A (en) 1981-03-24
DK162581A (da) 1981-10-12
IL62362A (en) 1984-12-31
NO811240L (no) 1981-10-12
IL62362A0 (en) 1981-05-20
DE3109794A1 (de) 1982-01-28
CH647519A5 (de) 1985-01-31
AU6941181A (en) 1981-10-15
FI810981L (fi) 1981-10-12

Similar Documents

Publication Publication Date Title
ES494614A0 (es) Procedimiento para la obtencion de 1,4-dihidropiridinas op- ticamente activas
AR229435A1 (es) Procedimiento para preparar 1,4-dihidro-2,6-dimetil-1-(2-(4-morfolinil)-etil)-4-(2-trifluorometil)-fenil)-3,5-piridindicarboxilato de dietilo,util como antihipertensivo
DK221486D0 (da) Skaereapparat, isaer til klipning af baand
DK154603C (da) Afsvaeringsmaskine, isaer til afsvaering af flaesk
ES527894A0 (es) Procedimiento para la obtencion de compuestos de 2-hidroximetil-3-carbamoil-1,4-dihidropiridina
DK379985A (da) Fremgangsmaade til fremstilling af 6-chlor-n-methyl-2,3,4,5-tetrahydro-lh-benzazepin
DK149855C (da) Analogifremgangsmaade til fremstilling af 1,4-dihydropyridinderivater
DK32186A (da) Maskine til profilklipning af strimmelmateriale, isaer metalplade
ES502429A0 (es) Procedimiento para la preparacion de 1-(4-clorobencidril)-4-(2,3-dihidroxipropil)-piperacina
DK539980A (da) Fremgangsmaade til fremstilling af 2-metyl-6-substituerede-4-i (2,3-diklorfenyl-1,4-dihydropyridin)-3,5-dikarboxylsyre-3,5-destere
DK154194C (da) Skaereskivemaskine, isaer til skaering af sukkerroer
ES544299A0 (es) Procedimiento para la obtencion de 1-(bis-(4-fluorofenil)- metil)-4-(3-fenil-2-propenil)-hexahidro-1h-1, 4-diacepina
ES538157A0 (es) Procedimiento para preparar derivados de 1,4-dihidropiridina
ES554062A0 (es) Procedimiento para la obtencion de 1,4-dihidropiridinas
ES482438A0 (es) Procedimiento para la preparacion de nuevos derivados de 2-(4-aminopiperidino)-3,4-dihidroquinoleina.
DK230785D0 (da) Spredemaskine, isaer saamaskine
ES482439A0 (es) Procedimiento para la preparacion de nuevos derivados de 1-(4-aminopiperidino)-3,4-dihidroisoquinoleina.
DK518783D0 (da) Fremgangsmade til fremstilling af n-substituerede 2-(r)-sulfinsyre-3-(s)-acylamino-4-oxo-azetidiner
ES549334A0 (es) Procedimiento para la obtencion de 1,4-dihidropiridinas
ES535342A0 (es) Procedimiento para la obtencion del 1,4-dihidro-2,6-dimetil-4-(3-nitrofenil)-3,5-piridincarboxilato de isopropil-(2-metoxietil)
ES499727A0 (es) Procedimiento para la obtencion del 2-(n-bencil-n-metil-ami-no-etilmetil-2,6-dimetil-4-(m-nitrofenil)-1,4-dihidropiridi-na-3,5-dicarboxilato
DK311783A (da) Skaereapparat, isaer til skaering af kabelaffald
ES544595A0 (es) Procedimiento para obtencion de 3-(2- (4-(p-fluorobenzoil) -1-piperidinil) etil) 2,4 (1h, 3h)-quinazolindiona
NL190929C (nl) 1-(Difenylmethyl)-4-(1,3-dioxolan-2-yl)-4-fenylbutylpiperazine, werkwijze voor de bereiding ervan alsmede farmaceutisch preparaat.
ES535616A0 (es) Procedimiento para la obtencion de 1, 4-dihidropiridinas asimetricas