AR209575A1 - A PROCEDURE FOR PREPARING NEW SUBSTITUTE DERIVATIVES OF 5-, 6-, 7-U8- (3-AMINO-2-OXISUSTITIDO) -PROPOXI-3,4-DIHIDROCARBOSTIRILO AND 5-, 6-, 7-U8- (3- AMINO-2-HYDROXY) PROPOXY -3,4-DIHYDROCARBOSTIRILE - Google Patents

A PROCEDURE FOR PREPARING NEW SUBSTITUTE DERIVATIVES OF 5-, 6-, 7-U8- (3-AMINO-2-OXISUSTITIDO) -PROPOXI-3,4-DIHIDROCARBOSTIRILO AND 5-, 6-, 7-U8- (3- AMINO-2-HYDROXY) PROPOXY -3,4-DIHYDROCARBOSTIRILE

Info

Publication number: AR209575A1
Authority: AR; Argentina
Prior art keywords: amino; oxisustitido; dihydrocarbostirile; dihidrocarbostirilo; propoxi
Prior art date: 1972-04-13

Application number

AR246548A

Other languages

Spanish (es)

Original Assignee

Otsuka Pharma Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1972-04-13

Filing date

1973-02-12

Publication date

1977-05-13

1972-09-14 Priority claimed from JP9255772A external-priority patent/JPS5324431B2/ja

1972-09-14 Priority claimed from JP47092558A external-priority patent/JPS5241268B2/ja

1972-09-14 Priority claimed from JP47092560A external-priority patent/JPS5246231B2/ja

1973-02-12 Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd

1977-05-13 Application granted granted Critical

1977-05-13 Publication of AR209575A1 publication Critical patent/AR209575A1/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/24—Oxygen atoms attached in position 8
- C07D215/26—Alcohols; Ethers thereof

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Quinoline Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

AR246548A 1972-04-13 1973-02-12 A PROCEDURE FOR PREPARING NEW SUBSTITUTE DERIVATIVES OF 5-, 6-, 7-U8- (3-AMINO-2-OXISUSTITIDO) -PROPOXI-3,4-DIHIDROCARBOSTIRILO AND 5-, 6-, 7-U8- (3- AMINO-2-HYDROXY) PROPOXY -3,4-DIHYDROCARBOSTIRILE AR209575A1 (en)

Applications Claiming Priority (8)

Application Number	Priority Date	Filing Date
JP47037181A JPS517672B2 (en)	1972-04-13	1972-04-13
JP47037182A JPS48103590A (en)	1972-04-13	1972-04-13
JP9255772A JPS5324431B2 (en)	1972-09-14	1972-09-14
JP47092558A JPS5241268B2 (en)	1972-09-14	1972-09-14
JP47092560A JPS5246231B2 (en)	1972-09-14	1972-09-14
JP47120953A JPS5229745B2 (en)	1972-04-13	1972-12-02
JP47125858A JPS5239036B2 (en)	1972-04-13	1972-12-14
JP47128972A JPS5241269B2 (en)	1972-04-13	1972-12-21

Publications (1)

Publication Number	Publication Date
AR209575A1 true AR209575A1 (en)	1977-05-13

Family

ID=27572212

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AR246548A AR209575A1 (en)	1972-04-13	1973-02-12	A PROCEDURE FOR PREPARING NEW SUBSTITUTE DERIVATIVES OF 5-, 6-, 7-U8- (3-AMINO-2-OXISUSTITIDO) -PROPOXI-3,4-DIHIDROCARBOSTIRILO AND 5-, 6-, 7-U8- (3- AMINO-2-HYDROXY) PROPOXY -3,4-DIHYDROCARBOSTIRILE

Country Status (17)

Country	Link
JP (5)	JPS517672B2 (en)
AR (1)	AR209575A1 (en)
AU (1)	AU475964B2 (en)
BE (1)	BE794669A (en)
CA (1)	CA1025447A (en)
CH (1)	CH575929A5 (en)
DD (2)	DD108293A5 (en)
DE (1)	DE2302027C2 (en)
DK (1)	DK141603B (en)
FI (1)	FI53703C (en)
FR (1)	FR2179715B1 (en)
GB (2)	GB1424572A (en)
HK (1)	HK19481A (en)
NL (1)	NL158176B (en)
NO (1)	NO140589C (en)
SE (1)	SE380018B (en)
YU (1)	YU41187B (en)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5082218A (en) *	1973-11-10	1975-07-03
US4022784A (en) *	1974-01-31	1977-05-10	Otsuka Pharmaceutical Company Limited	5-[1-Hydroxy-2-(substituted-amino)]alkyl-8-substituted-carbostyril and -3,4-dihydrocarbostyril derivatives
US4137331A (en)	1974-06-19	1979-01-30	Sandoz Ltd.	3-Piperidino-2-hydroxypropoxy substituted-2-indolinones
JPS516971A (en) *	1974-07-08	1976-01-20	Otsuka Pharma Co Ltd	Nitoro 3*44 jihidorokarubosuchirirujudotaino seizoho
JPS5129486A (en) *	1974-09-02	1976-03-12	Otsuka Pharma Co Ltd	* 33 arukiruamino 22 hidorokishi * purohokishi 3 44 jihidorokarubosuchirirujudotai no seizoho
JPS5148674A (en) *	1974-10-17	1976-04-26	Otsuka Pharma Co Ltd	3 44 jihidorokarubosuchirirujudotaino seizoho
JPS5152179A (en) *	1974-10-31	1976-05-08	Otsuka Pharma Co Ltd	KARUBOSUCHIRIRU JUDOTAINO SEIZOHO
JPS5152178A (en) *	1974-10-31	1976-05-08	Otsuka Pharma Co Ltd	KARUBOSUCHIRIRU JUDOTAINO SEIZOHO
JPS5152180A (en) *	1974-10-31	1976-05-08	Otsuka Pharma Co Ltd	KARUBOSUCHIRIRU JUDOTAINO SEIZOHO
FI58329C (en) *	1974-11-08	1981-01-12	Otsuka Pharma Co Ltd	PROCEDURE FOR FRAMSTATION OF I 8-STATIONARY SUBSTITUTES 5- (3'-ALKYLAMINO-2'-HYDROXY) PROPOXI-3,4-DIHYDROCARBOSTYRILDER
US4081447A (en) *	1975-04-09	1978-03-28	Abbott Laboratories	5-[2-Hydroxy-3-(3,4-dimethoxy phenethylamino)]-propoxy-3,4-dihydro carbostyril and pharmaceutically acceptable salts thereof
CH619453A5 (en) *	1976-03-17	1980-09-30	Otsuka Pharma Co Ltd
DE2719562C2 (en) *	1976-05-08	1986-05-07	Otsuka Pharmaceutical Co. Ltd., Tokio/Tokyo	3, 4-Dihydrocarbostyril derivatives, processes for their preparation and pharmaceuticals containing them
US4146630A (en) *	1976-11-12	1979-03-27	Boehringer Mannheim Gmbh	Blood pressure lowering and adrenergic β-receptor inhibiting 3-(4-phenoxymethylpiperidino)-propyl-phenyl ethers
JPS54130587A (en) *	1978-03-30	1979-10-09	Otsuka Pharmaceut Co Ltd	Carbostyryl derivative
DE2960178D1 (en) *	1978-06-06	1981-04-09	Hoechst Ag	New substituted phenylpiperazine derivatives, pharmaceutical compositions containing them and process for their preparation
DE2827566A1 (en) *	1978-06-23	1980-01-10	Boehringer Mannheim Gmbh	1,2-DIHYDRO-CHINOLIN-2-ON DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF
AU518814B2 (en) *	1979-01-30	1981-10-22	Otsuka Pharamaceutical Co.	Glaucoma treatment
DE3034237A1 (en) *	1979-09-18	1981-04-16	Otsuka Pharmaceutical Co. Ltd., Tokyo	CARBOSTYRIL DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND ANTIHISTAMINICALLY ACTIVE AGENTS CONTAINING THESE COMPOUNDS
JPS56122356A (en) *	1980-02-29	1981-09-25	Otsuka Pharmaceut Co Ltd	Carbostyril derivative
JPS58103343A (en) *	1981-12-15	1983-06-20	Ota Seiyaku Kk	Preparation of propanolamine compound
JPS597186A (en) *	1982-07-02	1984-01-14	Ota Seiyaku Kk	1,3,2-dioxathiolane 2-oxide derivative
JPS63193086U (en) *	1987-05-30	1988-12-13
DE3808136A1 (en) *	1988-03-11	1989-09-21	Thomae Gmbh Dr K	DRUGS CONTAINING CHINOLINE-2,5-DIONE, NEW CHINOLINE-2,5-DIONE AND METHOD OF PREPARING THEM
US5266577A (en) *	1988-08-10	1993-11-30	Otsuka Pharmaceutical Company Ltd.	Method of treating congestive heart failure using carbostyril derivatives
US5053514A (en) *	1988-08-10	1991-10-01	Otsuka Pharmaceutical Company, Limited	Cardiotonics
WO1993004042A1 (en) *	1991-08-23	1993-03-04	Otsuka Pharmaceutical Co., Ltd.	Carbostyril derivative and platelet agglutination inhibitor
ES2048108B1 (en) *	1992-07-17	1994-10-01	Lusochimica Spa	PROCEDURE FOR THE PREPARATION OF 5- (3-TERC-BUTILAMINO-2-HIDROXIPROPOXI) -3,4-DIHIDROCARBOESTIRILO.
IT1264816B1 (en) *	1993-07-28	1996-10-10	Pergam Srl	Process for the preparation of 3,4-dihydrocarbostyryl derivatives
CZ300351B6 (en) *	2005-05-26	2009-04-29	Zentiva, A. S.	Process for preparing 7-hydroxy-3,4-dihydrocarbostyril

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1058822A (en) *	1963-07-30	1967-02-15	Ici Ltd	3-amino-2-hydroxypropoxy heterocyclic derivatives
CH514611A (en) *	1968-07-05	1971-10-31	Cassella Farbwerke Mainkur Ag	Process for the preparation of derivatives of 2-oxo-1,2-dihydro-quinoline

1972
- 1972-04-13 JP JP47037181A patent/JPS517672B2/ja not_active Expired
- 1972-04-13 JP JP47037182A patent/JPS48103590A/ja active Pending
- 1972-12-02 JP JP47120953A patent/JPS5229745B2/ja not_active Expired
- 1972-12-14 JP JP47125858A patent/JPS5239036B2/ja not_active Expired
- 1972-12-21 JP JP47128972A patent/JPS5241269B2/ja not_active Expired
1973
- 1973-01-03 DK DK2773AA patent/DK141603B/en active Protection Beyond IP Right Term
- 1973-01-10 NO NO73105A patent/NO140589C/en unknown
- 1973-01-10 FR FR7300739A patent/FR2179715B1/fr not_active Expired
- 1973-01-11 CA CA161,000A patent/CA1025447A/en not_active Expired
- 1973-01-16 DE DE2302027A patent/DE2302027C2/en not_active Expired
- 1973-01-22 GB GB3417075A patent/GB1424572A/en not_active Expired
- 1973-01-22 GB GB325173A patent/GB1424571A/en not_active Expired
- 1973-01-29 BE BE794669D patent/BE794669A/en active Protection Beyond IP Right Term
- 1973-01-31 FI FI279/73A patent/FI53703C/en active
- 1973-02-02 DD DD168643A patent/DD108293A5/xx unknown
- 1973-02-02 DD DD178082*A patent/DD112446A5/xx unknown
- 1973-02-09 SE SE7301863A patent/SE380018B/xx unknown
- 1973-02-12 AR AR246548A patent/AR209575A1/en active
- 1973-02-20 NL NL7302353.A patent/NL158176B/en not_active IP Right Cessation
- 1973-03-19 CH CH393973A patent/CH575929A5/xx not_active IP Right Cessation
- 1973-04-11 AU AU54386/73A patent/AU475964B2/en not_active Expired
1979
- 1979-10-19 YU YU2549/79A patent/YU41187B/en unknown
1981
- 1981-05-14 HK HK194/81A patent/HK19481A/en unknown

Also Published As

Publication number	Publication date
JPS4981373A (en)	1974-08-06
DK141603B (en)	1980-05-05
GB1424571A (en)	1976-02-11
JPS4982673A (en)	1974-08-08
NO140589B (en)	1979-06-25
DD112446A5 (en)	1975-04-12
JPS517672B2 (en)	1976-03-10
GB1424572A (en)	1976-02-11
FR2179715A1 (en)	1973-11-23
YU254979A (en)	1982-10-31
JPS5229745B2 (en)	1977-08-03
CA1025447A (en)	1978-01-31
DD108293A5 (en)	1974-09-12
AU475964B2 (en)	1976-09-09
FI53703C (en)	1978-07-10
DK141603C (en)	1980-10-06
HK19481A (en)	1981-05-22
NL7302353A (en)	1973-10-16
JPS5239036B2 (en)	1977-10-03
JPS48103590A (en)	1973-12-25
JPS5241269B2 (en)	1977-10-17
DE2302027C2 (en)	1983-03-17
JPS48103589A (en)	1973-12-25
FR2179715B1 (en)	1976-12-03
AU5438673A (en)	1974-10-17
CH575929A5 (en)	1976-05-31
JPS4976878A (en)	1974-07-24
YU41187B (en)	1986-12-31
NO140589C (en)	1979-10-03
BE794669A (en)	1973-05-16
FI53703B (en)	1978-03-31
DE2302027A1 (en)	1973-12-06
SE380018B (en)	1975-10-27
NL158176B (en)	1978-10-16

Publication	Publication Date	Title
AR209575A1 (en)	1977-05-13	A PROCEDURE FOR PREPARING NEW SUBSTITUTE DERIVATIVES OF 5-, 6-, 7-U8- (3-AMINO-2-OXISUSTITIDO) -PROPOXI-3,4-DIHIDROCARBOSTIRILO AND 5-, 6-, 7-U8- (3- AMINO-2-HYDROXY) PROPOXY -3,4-DIHYDROCARBOSTIRILE
AR208768A1 (en)	1977-02-28	A PROCEDURE FOR PREPARING NEW DERIVATIVES OF 4-AMINO-3-SULFONAMIDO-PYRIDINE
AR230991A1 (en)	1984-08-31	A PROCEDURE FOR PREPARING NEW BENZOXAZOLIC DERIVATIVES
AR210990A1 (en)	1977-10-14	PROCEDURE FOR PREPARING DERIVATIVES OF N-PYRROLIDIN- OR PIPERIDIN- SUBSTITUTED 1,1-DIHIDEOPERFLUJOROALCOBENZAMIDAS
AR221816A1 (en)	1981-03-31	METHOD FOR PREPARING NEW BENCIMIDAZOLE-2-CARBAMATE-5 (6) -STITUTED DERIVATIVES
AR205129A1 (en)	1976-04-05	PROCEDURE FOR PREPARING NEW CHALCONA DERIVATIVES
AR204982A1 (en)	1976-03-31	PROCEDURE FOR PREPARING NEW DERIVATIVES OF 1-PHENOXY-2-HYDROXY-3-ISOPROPYLAMINE
AR195314A1 (en)	1973-09-28	PROCEDURE FOR PREPARING PIPERIDINOALKANOL ALPHA-ARIL-4-SUBSTITUTED DERIVATIVES
AR200347A1 (en)	1974-10-31	PROCEDURE FOR PREPARING PIPERAZINE DERIVATIVES
AR194803A1 (en)	1973-08-14	A PROCEDURE FOR PREPARING UREA
AR203991A1 (en)	1975-11-12	PROCEDURE FOR PREPARING DERIVATIVES OF (HYDROXY-2-AMINO-3-PROPOXI) -3-ISOINDOLINONE-1
AR211257A1 (en)	1977-11-15	A PROCEDURE FOR PREPARING DERIVATIVES OF 6-MENTIL-8-ALCOXICARBONIL-ERGOLINA AND 6-METTIL-8-ALOXICARBONIL-9-ERGOLENO
AR200387A1 (en)	1974-11-08	PROCEDURE FOR PREPARING TRIFLUOROMETHYLPHENYLPIPERAZINE DERIVATIVES
AR203500A1 (en)	1975-09-15	PROCEDURE FOR PREPARING NEW N-AMINOALKYL-2-AMINOINDANE DERIVATIVES
AR201414A1 (en)	1975-03-07	PROCEDURE FOR PREPARING NEW AMIDOXIMIC DERIVATIVES
AR211379Q (en)	1977-12-15	PROCEDURE FOR PREPARING DERIVATIVES OF IMIDAZOLIDIN -4- ONAS -1, 3- DISUSTITUIDAS
AR210133A1 (en)	1977-06-30	PROCEDURE FOR PREPARING NEW DERIVATIVES OF 3-AMINO-5-METHYL-PIRROL
AR211319A1 (en)	1977-11-20	PROCEDURE FOR PREPARING DERIVATIVES OF 8-AZA-9-OXO (AND DIOXO) -TIA-11,12-SECOPROSTAGLANDINS
AR200962A1 (en)	1974-12-27	PROCEDURE FOR PREPARING NEW DIGITOXYGENIN ALPHA-L-ARABINOSIDE DERIVATIVES
AR208186A1 (en)	1976-12-09	PROCEDURE FOR PREPARING NEW DERIVATIVES OF (2-HYDROXY-3-ALKYLAMINE PROPOXI) ISOCROMANONE
AR201666A1 (en)	1975-04-08	PROCEDURE FOR PREPARING DERIVATIVES OF DIMETHYLTETRAHYDRONAFTODIOXOLIL-OXY-PROPANOLES
SE391516B (en)	1977-02-21	PROCEDURE FOR PREPARING BENZYLAMINE DERIVATIVES
AR206653A1 (en)	1976-08-06	PROCEDURE FOR PREPARING NEW DERIVATIVES OF N-AMINOALKYL-2-AMINO-INDANO
AR192932A1 (en)	1973-03-21	A PROCEDURE FOR THE PREPARATION OF BENZOFURANIC DERIVATIVES
AR206584A1 (en)	1976-08-06	A PROCEDURE FOR OBTAINING DERIVATIVES OF 5-FENYL-1,4-BENZODIAZEPIN-2-ONAS