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AR206495A1 - PROCEDURE FOR THE PREPARATION OF NEW CARBOXYL ACIDS ALPHA- (2-ISOINDOLINIL-O 1,2,3,4-TETRAHIDRO-2-ISOQUINOLIL-FENIL) -ALIPATICOS - Google Patents

PROCEDURE FOR THE PREPARATION OF NEW CARBOXYL ACIDS ALPHA- (2-ISOINDOLINIL-O 1,2,3,4-TETRAHIDRO-2-ISOQUINOLIL-FENIL) -ALIPATICOS

Info

Publication number
AR206495A1
AR206495A1 AR245538A AR24553872A AR206495A1 AR 206495 A1 AR206495 A1 AR 206495A1 AR 245538 A AR245538 A AR 245538A AR 24553872 A AR24553872 A AR 24553872A AR 206495 A1 AR206495 A1 AR 206495A1
Authority
AR
Argentina
Prior art keywords
isoindolinil
alipaticos
isoquinolil
tetrahidro
fenil
Prior art date
Application number
AR245538A
Other languages
Spanish (es)
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH1383169A external-priority patent/CH577480A5/en
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Application granted granted Critical
Publication of AR206495A1 publication Critical patent/AR206495A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/56—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups bound to carbon atoms of six-membered aromatic rings and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/20—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/40—2,5-Pyrrolidine-diones
    • C07D207/404—2,5-Pyrrolidine-diones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. succinimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/44—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members
    • C07D207/444—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5
    • C07D207/448—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. maleimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/02—Preparation by ring-closure or hydrogenation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/74—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/78—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Indole Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AR245538A 1969-07-18 1972-12-07 PROCEDURE FOR THE PREPARATION OF NEW CARBOXYL ACIDS ALPHA- (2-ISOINDOLINIL-O 1,2,3,4-TETRAHIDRO-2-ISOQUINOLIL-FENIL) -ALIPATICOS AR206495A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US84324469A 1969-07-18 1969-07-18
US85615469A 1969-09-08 1969-09-08
CH1383169A CH577480A5 (en) 1969-07-18 1969-09-12 Alpha-aminophenyl aliphatic carboxylic acids - useful as anti-inflammatory agents, analgesics and anti-mycotics
US840670A 1970-02-03 1970-02-03
US4043670A 1970-05-25 1970-05-25

Publications (1)

Publication Number Publication Date
AR206495A1 true AR206495A1 (en) 1976-07-30

Family

ID=27509487

Family Applications (7)

Application Number Title Priority Date Filing Date
AR245379A AR199095A1 (en) 1969-07-18 1972-11-29 PROCEDURE FOR THE ELABORATION OF ALPHA- (AMINO-PHENYL) -ALIPHATIC CARBOXYL ACID COMPOUNDS
AR245378A AR194630A1 (en) 1969-07-18 1972-11-29 PROCEDURE FOR OBTAINING ALPHA (AMINO-FENYL) CARBOXYL ACID COMPOUNDS
AR245380A AR198962A1 (en) 1969-07-18 1972-11-29 PROCEDURE FOR THE ELABORATION OF ALPHA CARBOXYL ACID COMPOUNDS - (AMINO-FENYL) -ALIPHATIC
AR245537A AR200992A1 (en) 1969-07-18 1972-12-07 PROCEDURE FOR THE ELABORATION OF ALPHA- (AMINOPHENYL-ALIPHATICS OF CARBOXYL ACID, OR ITS SALTS
AR245536A AR201655A1 (en) 1969-07-18 1972-12-07 PROCEDURE FOR THE ELABORATION OF ALPHA- (AMINO-FENLI) -ALIPHATIC CARBOXYL ACID COMPOUNDS
AR245538A AR206495A1 (en) 1969-07-18 1972-12-07 PROCEDURE FOR THE PREPARATION OF NEW CARBOXYL ACIDS ALPHA- (2-ISOINDOLINIL-O 1,2,3,4-TETRAHIDRO-2-ISOQUINOLIL-FENIL) -ALIPATICOS
AR247668A AR199480A1 (en) 1969-07-18 1973-04-24 PROCEDURE FOR THE ELABORATION OF NEW ALPHA- (AMINO-PHENYL) -ALIPHATIC CARBOXYL ACIDS AND THEIR FUNCTIONAL DERIVATIVES

Family Applications Before (5)

Application Number Title Priority Date Filing Date
AR245379A AR199095A1 (en) 1969-07-18 1972-11-29 PROCEDURE FOR THE ELABORATION OF ALPHA- (AMINO-PHENYL) -ALIPHATIC CARBOXYL ACID COMPOUNDS
AR245378A AR194630A1 (en) 1969-07-18 1972-11-29 PROCEDURE FOR OBTAINING ALPHA (AMINO-FENYL) CARBOXYL ACID COMPOUNDS
AR245380A AR198962A1 (en) 1969-07-18 1972-11-29 PROCEDURE FOR THE ELABORATION OF ALPHA CARBOXYL ACID COMPOUNDS - (AMINO-FENYL) -ALIPHATIC
AR245537A AR200992A1 (en) 1969-07-18 1972-12-07 PROCEDURE FOR THE ELABORATION OF ALPHA- (AMINOPHENYL-ALIPHATICS OF CARBOXYL ACID, OR ITS SALTS
AR245536A AR201655A1 (en) 1969-07-18 1972-12-07 PROCEDURE FOR THE ELABORATION OF ALPHA- (AMINO-FENLI) -ALIPHATIC CARBOXYL ACID COMPOUNDS

Family Applications After (1)

Application Number Title Priority Date Filing Date
AR247668A AR199480A1 (en) 1969-07-18 1973-04-24 PROCEDURE FOR THE ELABORATION OF NEW ALPHA- (AMINO-PHENYL) -ALIPHATIC CARBOXYL ACIDS AND THEIR FUNCTIONAL DERIVATIVES

Country Status (11)

Country Link
JP (19) JPS5035076B1 (en)
AR (7) AR199095A1 (en)
BG (4) BG20781A3 (en)
CA (1) CA990299A (en)
CY (1) CY811A (en)
HU (1) HU167239B (en)
IE (1) IE34380B1 (en)
KE (1) KE2544A (en)
MY (1) MY7500150A (en)
OA (1) OA149E (en)
RO (1) RO62856A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017053787A (en) 2015-09-11 2017-03-16 株式会社デンソー Air flow measurement device

Also Published As

Publication number Publication date
AR199095A1 (en) 1974-08-08
JPS5427334B1 (en) 1979-09-10
JPS5425021B1 (en) 1979-08-24
JPS5426536B1 (en) 1979-09-04
AR201655A1 (en) 1975-04-08
JPS5422971B1 (en) 1979-08-10
BG19588A3 (en) 1975-06-25
AR198962A1 (en) 1974-07-31
OA149E (en) 1971-12-24
IE34380B1 (en) 1975-04-30
BG20781A3 (en) 1975-12-20
BG20563A3 (en) 1975-12-05
AR194630A1 (en) 1973-07-31
JPS5422976B1 (en) 1979-08-10
AR199480A1 (en) 1974-09-09
JPS556629B1 (en) 1980-02-18
JPS5432777B1 (en) 1979-10-16
JPS556628B1 (en) 1980-02-18
JPS5344468B1 (en) 1978-11-29
BG20099A3 (en) 1975-10-30
JPS5427333B1 (en) 1979-09-10
KE2544A (en) 1975-07-25
RO62856A (en) 1978-01-15
JPS5536660B1 (en) 1980-09-22
JPS5745429B1 (en) 1982-09-28
AR200992A1 (en) 1975-02-06
CA990299A (en) 1976-06-01
IE34380L (en) 1971-01-18
JPS557425B1 (en) 1980-02-25
JPS5432778B1 (en) 1979-10-16
JPS5432779B1 (en) 1979-10-16
JPS556627B1 (en) 1980-02-18
MY7500150A (en) 1975-12-31
JPS5422970B1 (en) 1979-08-10
HU167239B (en) 1975-09-27
CY811A (en) 1976-12-01
JPS5344469B1 (en) 1978-11-29
JPS5035076B1 (en) 1975-11-13

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