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AR132880A1 - Derivados de heteroaril como inhibidores de ddr - Google Patents

Derivados de heteroaril como inhibidores de ddr

Info

Publication number
AR132880A1
AR132880A1 ARP240101442A ARP240101442A AR132880A1 AR 132880 A1 AR132880 A1 AR 132880A1 AR P240101442 A ARP240101442 A AR P240101442A AR P240101442 A ARP240101442 A AR P240101442A AR 132880 A1 AR132880 A1 AR 132880A1
Authority
AR
Argentina
Prior art keywords
ddr
compounds
inhibitors
heteroaryl derivatives
ddr inhibitors
Prior art date
Application number
ARP240101442A
Other languages
English (en)
Inventor
Laura Carzaniga
Fabio Rancati
Jonathan Andrew Spencer
Benjamin Paul Whittaker
Zuzana Hamasova
Andrea Rizzi
Roberta Mazzucato
Stefano Levanto
Robert Stuart Laurie Chapman
Gabriele Fumagalli
Nicol Iotti
Marta Giuliani
Dean Alfie Stimpson
Original Assignee
Chiesi Farm Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiesi Farm Spa filed Critical Chiesi Farm Spa
Publication of AR132880A1 publication Critical patent/AR132880A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invención se refiere a compuestos de la fórmula (1) inhibidores de Receptores de Dominio de Discoidina (inhibidores de DDR), métodos de preparación de tales compuestos, compuestos intermedios útiles en tales preparaciones, composiciones farmacéuticas que los contienen y uso terapéutico de los mismos. Los compuestos de la invención pueden ser útiles, por ejemplo, en el tratamiento de muchos trastornos asociados a mecanismos DDR.
ARP240101442A 2023-06-07 2024-06-06 Derivados de heteroaril como inhibidores de ddr AR132880A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP23177905 2023-06-07

Publications (1)

Publication Number Publication Date
AR132880A1 true AR132880A1 (es) 2025-08-06

Family

ID=86732124

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP240101442A AR132880A1 (es) 2023-06-07 2024-06-06 Derivados de heteroaril como inhibidores de ddr

Country Status (6)

Country Link
CN (1) CN121285552A (es)
AR (1) AR132880A1 (es)
AU (1) AU2024284017A1 (es)
MX (1) MX2025014449A (es)
TW (1) TW202510866A (es)
WO (1) WO2024251855A1 (es)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017005583A1 (en) 2015-07-03 2017-01-12 F. Hoffmann-La Roche Ag Triaza-spirodecanones as ddr1 inhibitors
MX2018002018A (es) 2015-08-31 2018-03-26 Toray Industries Derivado de urea y uso del mismo.
US20190374526A1 (en) 2018-06-06 2019-12-12 Merck Sharp & Dohme Corp. Substituted Heterocyclic Compounds as Inhibitors of PRDM9
GB202111740D0 (en) 2021-08-16 2021-09-29 Redx Pharma Plc Fibrosis
WO2023064370A1 (en) 2021-10-13 2023-04-20 Board Of Trustees Of Michigan State University Soluble epoxide hydrolase inhibitors and use thereof
CN118201918A (zh) 2021-11-04 2024-06-14 莱德克斯制药公共有限公司 用于治疗癌症和纤维化疾病的ddr1和ddr2抑制剂

Also Published As

Publication number Publication date
TW202510866A (zh) 2025-03-16
MX2025014449A (es) 2026-01-07
AU2024284017A1 (en) 2026-01-22
WO2024251855A1 (en) 2024-12-12
CN121285552A (zh) 2026-01-06

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