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AR131494A1 - Vehículos de conjugación a base de proteína - Google Patents

Vehículos de conjugación a base de proteína

Info

Publication number
AR131494A1
AR131494A1 ARP230103535A ARP230103535A AR131494A1 AR 131494 A1 AR131494 A1 AR 131494A1 AR P230103535 A ARP230103535 A AR P230103535A AR P230103535 A ARP230103535 A AR P230103535A AR 131494 A1 AR131494 A1 AR 131494A1
Authority
AR
Argentina
Prior art keywords
protein
molecule
building block
based carrier
optionally
Prior art date
Application number
ARP230103535A
Other languages
English (en)
Inventor
Carlo Boutton
Peter Casteels
Berthelot Alexandra Ferrier
Raf Ponsaerts
John Reed
Original Assignee
Ablynx Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ablynx Nv filed Critical Ablynx Nv
Publication of AR131494A1 publication Critical patent/AR131494A1/es

Links

Classifications

    • C07K16/11—
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2318/00—Antibody mimetics or scaffolds
    • C07K2318/20—Antigen-binding scaffold molecules wherein the scaffold is not an immunoglobulin variable region or antibody mimetics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/11—Protein-serine/threonine kinases (2.7.11)
    • C12Y207/11022—Cyclin-dependent kinase (2.7.11.22)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Mycology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

La presente tecnología se refiere al campo de la administración de fármacos y proporciona moléculas que comprenden o consisten en al menos un bloque de construcción vehicular a base de proteína, en donde el bloque de construcción vehicular a base de proteína comprende al menos uno, preferiblemente al menos dos, puntos de unión o sitios de conjugación. En particular, la tecnología proporciona una molécula que comprende al menos un bloque de construcción a base de proteína, en donde el al menos un bloque de construcción a base de proteína: a) comprende al menos un sitio de conjugación o punto de unión; b) tiene una masa molecular de 2,5 a 70 kDa; c) tiene una estructura tridimensional (3D) globular; d) tiene una solubilidad de 10 mg/mL o más, medida en una solución acuosa a temperatura ambiente; y no se une específicamente a ninguna proteína humana o se une a una o más proteínas humanas con un valor de KD mayor de 5 ´ 10⁻⁴ moles/litro. Reivindicación 1: Una molécula que comprende al menos un bloque de construcción a base de proteína, en donde el al menos un bloque de construcción a base de proteína: a) comprende al menos dos sitios de conjugación o puntos de unión; b) tiene una masa molecular de aproximadamente 2,5 a aproximadamente 70 kDa; c) tiene una estructura tridimensional (3D) globular; d) tiene una solubilidad de 10 mg/mL o más, medida en una solución acuosa a temperatura ambiente, en donde la solución acuosa es tampón citrato o PBS, a pH 7,0 o 7,4; e) no se une específicamente a ninguna proteína humana o se une a una o más proteínas humanas con un valor de KD mayor de 5 ´ 10⁻⁴ moles/litro, como se determina por resonancia de plasmón superficial, por ejemplo, como se describe en Ober et al. 2001, Intern. Immunology 13: 1551-1559; y f) no comprende o consiste en una secuencia de aminoácidos seleccionada de la SEQ ID Nº 1 - 34 como se representa en las Tablas A-1 y A-2 de WO 2016/055656 y/o la SEQ ID Nº 1 - 12 como se representa en la Tabla A-1 de WO 2010/139808. Reivindicación 25: Un ácido nucleico que codifica la molécula como se define en una cualquiera de las reivindicaciones 1 a 24, parte de la molécula como se define en una cualquiera de las reivindicaciones 1 a 24 y/o el bloque de construcción a base de proteína como se define en una cualquiera de las reivindicaciones 1 - 19. Reivindicación 26: Un vector que comprende el ácido nucleico como se define en la reivindicación 25. Reivindicación 27: Una composición que comprende la molécula como se define en una cualquiera de las reivindicaciones 1 a 24, tal como una composición farmacéutica. Reivindicación 28: Un método para producir la molécula como se define en una cualquiera de las reivindicaciones 1 a 24, en donde el método comprende: a) expresar, en una célula huésped u organismo huésped adecuado o en otro sistema de expresión adecuado, una secuencia de ácido nucleico que codifica el al menos un bloque de construcción vehicular a base de proteína y/o la molécula o parte de la molécula como se define en una cualquiera de las reivindicaciones 1 a 24; b) opcionalmente, aislar y/o purificar el al menos un bloque de construcción vehicular a base de proteína y/o la molécula o parte de la molécula expresado en a); c) opcionalmente, conjugar una o más cargas (adicionales) al o a los puntos de unión o sitios de conjugación del bloque de construcción vehicular a base de proteína. Reivindicación 29: Un método para producir la molécula como se define en una cualquiera de las reivindicaciones 1 a 24, en donde el método comprende: a) sintetizar químicamente el al menos un bloque de construcción vehicular a base de proteína y/o la molécula o parte de la molécula como se define en una cualquiera de las reivindicaciones 1 a 24, preferiblemente usando síntesis de péptidos en fase sólida; b) opcionalmente, aislar y/o purificar el al menos un bloque de construcción vehicular a base de proteína y/o la molécula o parte de la molécula sintetizado en a); c) opcionalmente, conjugar una o más cargas (adicionales) al o a los puntos de unión o sitios de conjugación del bloque de construcción vehicular a base de proteína.
ARP230103535A 2022-12-23 2023-12-22 Vehículos de conjugación a base de proteína AR131494A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202263476994P 2022-12-23 2022-12-23
EP23150688 2023-01-09

Publications (1)

Publication Number Publication Date
AR131494A1 true AR131494A1 (es) 2025-03-26

Family

ID=89542217

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP230103535A AR131494A1 (es) 2022-12-23 2023-12-22 Vehículos de conjugación a base de proteína

Country Status (4)

Country Link
US (1) US20240415974A1 (es)
AR (1) AR131494A1 (es)
TW (1) TW202440614A (es)
WO (1) WO2024133935A1 (es)

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TW202543670A (zh) 2023-12-22 2025-11-16 比利時商艾伯霖克斯公司 用於核內投予之基於蛋白質的接合載劑

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