AR131303A1 - PAPAIN-LIKE PROTEASE INHIBITORS (PLpro) - Google Patents
PAPAIN-LIKE PROTEASE INHIBITORS (PLpro)Info
- Publication number
- AR131303A1 AR131303A1 ARP230103334A ARP230103334A AR131303A1 AR 131303 A1 AR131303 A1 AR 131303A1 AR P230103334 A ARP230103334 A AR P230103334A AR P230103334 A ARP230103334 A AR P230103334A AR 131303 A1 AR131303 A1 AR 131303A1
- Authority
- AR
- Argentina
- Prior art keywords
- plpro
- papain
- protease inhibitors
- activity
- compounds
- Prior art date
Links
- 101800004803 Papain-like protease Proteins 0.000 title abstract 4
- 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 title 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 title 1
- 208000036142 Viral infection Diseases 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 230000009385 viral infection Effects 0.000 abstract 2
- 208000001528 Coronaviridae Infections Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Compuestos de la fórmula (1) y sales aceptables desde el punto de vista farmacéutico de este como se definen en la descripción; su uso en medicina; composiciones que los contienen; procesos para su preparación; e intermedios usados en tales procesos. Los compuestos de la fórmula (1) pueden inhibir la actividad de la proteasa similar a la papaína (PLpro) y pueden ser de utilidad en el tratamiento de infecciones virales, en particular infecciones virales asociadas con la actividad y/o la expresión de PLpro tales como infecciones por coronavirus.Compounds of formula (1) and pharmaceutically acceptable salts thereof as defined in the description; their use in medicine; compositions containing them; processes for their preparation; and intermediates used in such processes. The compounds of formula (1) can inhibit papain-like protease (PLpro) activity and may be useful in the treatment of viral infections, in particular viral infections associated with PLpro activity and/or expression such as coronavirus infections.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063495810P | 2020-04-13 | 2020-04-13 | |
| US202063505758P | 2020-06-02 | 2020-06-02 | |
| US202063594119P | 2020-10-30 | 2020-10-30 | |
| US202263386748P | 2022-12-09 | 2022-12-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR131303A1 true AR131303A1 (en) | 2025-03-05 |
Family
ID=95154019
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP230103334A AR131303A1 (en) | 2020-04-13 | 2023-12-07 | PAPAIN-LIKE PROTEASE INHIBITORS (PLpro) |
Country Status (1)
| Country | Link |
|---|---|
| AR (1) | AR131303A1 (en) |
-
2023
- 2023-12-07 AR ARP230103334A patent/AR131303A1/en unknown
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