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AR131163A1 - Métodos para producir proteínas - Google Patents

Métodos para producir proteínas

Info

Publication number
AR131163A1
AR131163A1 ARP230103173A ARP230103173A AR131163A1 AR 131163 A1 AR131163 A1 AR 131163A1 AR P230103173 A ARP230103173 A AR P230103173A AR P230103173 A ARP230103173 A AR P230103173A AR 131163 A1 AR131163 A1 AR 131163A1
Authority
AR
Argentina
Prior art keywords
binding molecules
disulfide
methods
antigen
regions
Prior art date
Application number
ARP230103173A
Other languages
English (en)
Inventor
Katerina Farukshina
Raiji Kawade
Shohei Kobayashi
Junichi Nakayama
Takahiro Nonaka
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of AR131163A1 publication Critical patent/AR131163A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

En una forma de forma de realización, se descubrió que una preparación que contiene moléculas de unión a antígeno que tienen al menos un enlace disulfuro formado entre residuos de aminoácidos en regiones distintas de la región bisagra puede producirse más eficientemente y con alta reproducibilidad llevando a cabo lo siguiente en cromatografía: poner en contacto una mezcla que contenga moléculas de unión a antígeno que tengan al menos un enlace disulfuro formado entre residuos de aminoácidos en regiones distintas de la región bisagra y formas mal unidas por disulfuro y/o formas no unidas por disulfuro de las moléculas de unión a antígeno con una solución que contenga un agente reductor; y posteriormente, eliminar el agente reductor.
ARP230103173A 2022-11-25 2023-11-24 Métodos para producir proteínas AR131163A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2022187883 2022-11-25

Publications (1)

Publication Number Publication Date
AR131163A1 true AR131163A1 (es) 2025-02-19

Family

ID=91196134

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP230103173A AR131163A1 (es) 2022-11-25 2023-11-24 Métodos para producir proteínas

Country Status (10)

Country Link
EP (1) EP4624489A1 (es)
JP (1) JPWO2024111657A1 (es)
KR (1) KR20250111141A (es)
CN (1) CN120265651A (es)
AR (1) AR131163A1 (es)
AU (1) AU2023387113A1 (es)
IL (1) IL320881A (es)
MX (1) MX2025005439A (es)
TW (1) TW202436348A (es)
WO (2) WO2024111657A1 (es)

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Also Published As

Publication number Publication date
AU2023387113A1 (en) 2025-05-15
IL320881A (en) 2025-07-01
JPWO2024111657A1 (es) 2024-05-30
WO2024111657A1 (ja) 2024-05-30
KR20250111141A (ko) 2025-07-22
MX2025005439A (es) 2025-06-02
CN120265651A (zh) 2025-07-04
EP4624489A1 (en) 2025-10-01
WO2025109783A1 (ja) 2025-05-30
TW202436348A (zh) 2024-09-16

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