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AR134196A1 - Derivados de amidas heteroarílicas como inhibidores de los canales de sodio - Google Patents

Derivados de amidas heteroarílicas como inhibidores de los canales de sodio

Info

Publication number
AR134196A1
AR134196A1 ARP240102953A ARP240102953A AR134196A1 AR 134196 A1 AR134196 A1 AR 134196A1 AR P240102953 A ARP240102953 A AR P240102953A AR P240102953 A ARP240102953 A AR P240102953A AR 134196 A1 AR134196 A1 AR 134196A1
Authority
AR
Argentina
Prior art keywords
compounds
sodium channel
amide derivatives
heteroaryl amide
channel inhibitors
Prior art date
Application number
ARP240102953A
Other languages
English (en)
Inventor
Claudio Fiorelli
Giacomo Fossati
Luca Mengozzi
Giampaolo Mosca
Riccardo Patacchini
Andrea Rizzi
Original Assignee
Chiesi Farm Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiesi Farm Spa filed Critical Chiesi Farm Spa
Publication of AR134196A1 publication Critical patent/AR134196A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invención se refiere en general a compuestos de la fórmula (1) que inhiben la actividad del canal de sodio (NaV); en particular, la invención se refiere a compuestos que son derivados de amida de heteroarilo, incluidas formas zwitteriónicas y sales farmacéuticamente aceptables de los mismos, métodos de preparación de dichos compuestos y uso terapéutico de los mismos. Los compuestos de la invención pueden ser útiles, por ejemplo, en el tratamiento de muchos trastornos asociados con NaV, tales como enfermedades respiratorias.
ARP240102953A 2023-11-02 2024-10-30 Derivados de amidas heteroarílicas como inhibidores de los canales de sodio AR134196A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP23207536 2023-11-02

Publications (1)

Publication Number Publication Date
AR134196A1 true AR134196A1 (es) 2025-12-10

Family

ID=88689604

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP240102953A AR134196A1 (es) 2023-11-02 2024-10-30 Derivados de amidas heteroarílicas como inhibidores de los canales de sodio

Country Status (2)

Country Link
AR (1) AR134196A1 (es)
WO (1) WO2025093589A1 (es)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3255207A (en) 1962-02-09 1966-06-07 Astra Ab Quaternary ammonium salts containing anilido groups
WO1999063985A1 (en) 1998-06-09 1999-12-16 Nortran Pharmaceuticals, Inc. Compositions and methods for treatment of cough
WO2013003490A1 (en) 2011-06-28 2013-01-03 James Hardie Technology Limited Novel oriented polymer composite article, composition and method of manufacture
WO2021091585A1 (en) * 2019-11-06 2021-05-14 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use

Also Published As

Publication number Publication date
WO2025093589A1 (en) 2025-05-08

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