AR121415A1 - p38 KINASE INHIBITORS THAT REDUCE EXPRESSION OF DUX4 AND DOWNSTREAM GENES FOR USE IN THE TREATMENT OF FSHD - Google Patents
p38 KINASE INHIBITORS THAT REDUCE EXPRESSION OF DUX4 AND DOWNSTREAM GENES FOR USE IN THE TREATMENT OF FSHDInfo
- Publication number
- AR121415A1 AR121415A1 ARP180102885A ARP180102885A AR121415A1 AR 121415 A1 AR121415 A1 AR 121415A1 AR P180102885 A ARP180102885 A AR P180102885A AR P180102885 A ARP180102885 A AR P180102885A AR 121415 A1 AR121415 A1 AR 121415A1
- Authority
- AR
- Argentina
- Prior art keywords
- dux4
- fshd
- treatment
- kinase inhibitors
- reduce expression
- Prior art date
Links
- 229940043355 kinase inhibitor Drugs 0.000 title abstract 4
- 239000003757 phosphotransferase inhibitor Substances 0.000 title abstract 4
- 208000037149 Facioscapulohumeral dystrophy Diseases 0.000 title abstract 3
- 208000008570 facioscapulohumeral muscular dystrophy Diseases 0.000 title abstract 3
- 102100021158 Double homeobox protein 4 Human genes 0.000 title abstract 2
- 101000968549 Homo sapiens Double homeobox protein 4 Proteins 0.000 title abstract 2
- 108090000623 proteins and genes Proteins 0.000 title 1
- 102000002574 p38 Mitogen-Activated Protein Kinases Human genes 0.000 abstract 3
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 101150054841 DUX4 gene Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 210000000663 muscle cell Anatomy 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Reivindicación 1: Un inhibidor de la quinasa p38, en donde el inhibidor de la quinasa p38 posee la fórmula (1), o una sal farmacéuticamente aceptable del mismo; en el que la administración del inhibidor de la quinasa p38 reduce los niveles de expresión de un polipéptido DUX4 y/o un polipéptido codificado por un gen DUX4 corriente abajo en las células musculares del sujeto, caracterizado porque se usa para tratar la distrofia muscular facioescapulohumeral (FSHD), comprendiendo administrar a un sujeto que lo necesite, una cantidad eficaz de dicho compuesto.Claim 1: A p38 kinase inhibitor, wherein the p38 kinase inhibitor has the formula (1), or a pharmaceutically acceptable salt thereof; wherein the administration of the p38 kinase inhibitor reduces the expression levels of a DUX4 polypeptide and/or a polypeptide encoded by a downstream DUX4 gene in the muscle cells of the subject, characterized in that it is used to treat facioscapulohumeral muscular dystrophy ( FSHD), comprising administering to a subject in need thereof, an effective amount of said compound.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762568673P | 2017-10-05 | 2017-10-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR121415A1 true AR121415A1 (en) | 2022-06-08 |
Family
ID=82401538
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP180102885A AR121415A1 (en) | 2017-10-05 | 2018-10-05 | p38 KINASE INHIBITORS THAT REDUCE EXPRESSION OF DUX4 AND DOWNSTREAM GENES FOR USE IN THE TREATMENT OF FSHD |
Country Status (1)
| Country | Link |
|---|---|
| AR (1) | AR121415A1 (en) |
-
2018
- 2018-10-05 AR ARP180102885A patent/AR121415A1/en unknown
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| AR121415A1 (en) | p38 KINASE INHIBITORS THAT REDUCE EXPRESSION OF DUX4 AND DOWNSTREAM GENES FOR USE IN THE TREATMENT OF FSHD |