[go: up one dir, main page]

AR121176A1 - Un éter poliglicidílico de poliglicerol hiperramificado y su uso como reticulante de polisacáridos - Google Patents

Un éter poliglicidílico de poliglicerol hiperramificado y su uso como reticulante de polisacáridos

Info

Publication number
AR121176A1
AR121176A1 ARP200102718A ARP200102718A AR121176A1 AR 121176 A1 AR121176 A1 AR 121176A1 AR P200102718 A ARP200102718 A AR P200102718A AR P200102718 A ARP200102718 A AR P200102718A AR 121176 A1 AR121176 A1 AR 121176A1
Authority
AR
Argentina
Prior art keywords
formula
moiety
polysaccharide
group
polyglycidyl ether
Prior art date
Application number
ARP200102718A
Other languages
English (en)
Inventor
Benedictis Vincenzo Maria De
Original Assignee
Biopolimeri S R L
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biopolimeri S R L filed Critical Biopolimeri S R L
Publication of AR121176A1 publication Critical patent/AR121176A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/24—Ethers with hydroxy compounds containing no oxirane rings with polyhydroxy compounds
    • C07D303/27—Ethers with hydroxy compounds containing no oxirane rings with polyhydroxy compounds having all hydroxyl radicals etherified with oxirane containing compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K5/00—Use of organic ingredients
    • C08K5/04—Oxygen-containing compounds
    • C08K5/05—Alcohols; Metal alcoholates
    • C08K5/053—Polyhydroxylic alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/738—Cross-linked polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/731—Cellulose; Quaternized cellulose derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/732—Starch; Amylose; Amylopectin; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/86—Polyethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B15/00—Preparation of other cellulose derivatives or modified cellulose, e.g. complexes
    • C08B15/005—Crosslinking of cellulose derivatives
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B33/00—Preparation of derivatives of amylose
    • C08B33/04—Ethers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K5/00—Use of organic ingredients
    • C08K5/04—Oxygen-containing compounds
    • C08K5/15—Heterocyclic compounds having oxygen in the ring
    • C08K5/151—Heterocyclic compounds having oxygen in the ring having one oxygen atom in the ring
    • C08K5/1515—Three-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/91—Injection

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Birds (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente se refiere a un éter poliglicidílico de poliglicerol hiperramificado que tiene un peso molecular de 750 a 15.000 Da; y un peso equivalente de epoxi de 183 a 7.000 g/eq. También se refiere a un polisacárido reticulado que es obtenible mediante reticulación del polisacárido con el éter poliglicidílico de poliglicerol hiperramificado. La presente también se refiere a procedimientos para su preparación y sus usos en el campo de terapia, cosmética, agricultura y alimentación. Reivindicación 1: Un compuesto de fórmula (1), o, como alternativa, un compuesto de fórmula (2) en donde cada R¹ se selecciona de manera independiente del grupo que consiste en R² y R³; R² es un resto de fórmula (5); R³ es un resto de fórmula (6); b es un número entero seleccionado del grupo que consiste en 1 a 70; c es un número entero seleccionado del grupo que consiste en 1 a 70; d es un número entero seleccionado del grupo que consiste en 1 a 70; que tiene un peso molecular (Pₘ) de 750 a 15.000 Da medido por el método de cromatografía líquida; y un peso equivalente de epoxi de 183 a 7.000 g/eq medido por titulación rápida asistida por ultrasonidos con HCl. Reivindicación 5: Un polisacárido reticulado de fórmula (3) o, como alternativa, un polisacárido reticulado de fórmula (4) en donde cada R¹ se selecciona de manera independiente del grupo que consiste en R², R³, R⁴ y R⁵; R² es un resto de fórmula (5); R³ es un resto de fórmula (6); R⁴ es un resto de fórmula (7); R⁵ es un resto de fórmula (8); PS es un polisacárido; y el polisacárido reticulado tiene un porcentaje de reticulación de 0,077 a 0,450%.
ARP200102718A 2019-10-01 2020-09-30 Un éter poliglicidílico de poliglicerol hiperramificado y su uso como reticulante de polisacáridos AR121176A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP19200803 2019-10-01

Publications (1)

Publication Number Publication Date
AR121176A1 true AR121176A1 (es) 2022-04-27

Family

ID=68109209

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP200102718A AR121176A1 (es) 2019-10-01 2020-09-30 Un éter poliglicidílico de poliglicerol hiperramificado y su uso como reticulante de polisacáridos

Country Status (11)

Country Link
US (1) US20220380329A1 (es)
EP (1) EP4038105B1 (es)
JP (1) JP7784138B2 (es)
KR (1) KR20220075334A (es)
CN (1) CN114502599B (es)
AR (1) AR121176A1 (es)
BR (1) BR112022005786A2 (es)
ES (1) ES2974643T3 (es)
MX (1) MX2022003750A (es)
PL (1) PL4038105T3 (es)
WO (1) WO2021064006A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR126276A1 (es) 2021-07-01 2023-10-04 Biopolimeri S R L Composición de ácido hialurónico reticulado con anestésicos locales
CN113679880A (zh) * 2021-08-25 2021-11-23 西北大学 一种裸藻多糖水凝胶敷料及其制备方法和应用
CN116207256B (zh) * 2022-09-23 2025-08-08 常熟威怡科技有限公司 一种电池的负极浆料及铜箔-石墨负极
CN118267524A (zh) * 2022-12-29 2024-07-02 台北医学大学 玻尿酸组合物、皮下填充剂及其制造方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB757386A (en) * 1953-03-14 1956-09-19 Fothergill & Harvey Ltd A chemical modification of cellulose
JPH10212671A (ja) * 1997-01-28 1998-08-11 Kanebo Ltd セルロース系繊維及びその繊維構造物の架橋改質法
JP2002233542A (ja) * 2001-02-09 2002-08-20 Shiseido Co Ltd 創傷被覆材及びその製造方法
TWI251596B (en) * 2002-12-31 2006-03-21 Ind Tech Res Inst Method for producing a double-crosslinked hyaluronate material
JP4015988B2 (ja) * 2003-12-19 2007-11-28 トン ハイ バイオテクノロジー コーポレイション 三次元架橋した、安定した生分解性の高吸水性γポリグルタミン酸ヒドロゲル、及びその調製方法
WO2008034176A1 (en) * 2006-09-19 2008-03-27 Ultraceuticals R & D Pty Ltd Cross-linked polysaccharide gels
JP5325542B2 (ja) * 2007-12-19 2013-10-23 ライオン株式会社 ハイパーブランチポリマーおよびその誘導体
US9408797B2 (en) * 2011-06-03 2016-08-09 Allergan, Inc. Dermal filler compositions for fine line treatment
FR2983483B1 (fr) * 2011-12-02 2014-11-14 Vivacy Lab Procede de substitution et reticulation simultanees d'un polysaccharide via ses fonctions hydroxyles
ITMI20120732A1 (it) * 2012-05-03 2013-11-04 B S Srl Polisaccaridi reticolati a memoria di forma
WO2017016917A1 (en) * 2015-07-27 2017-02-02 Galderma Sa A process for efficient cross-linking of hyaluronic acid
US9926665B2 (en) * 2016-02-25 2018-03-27 International Paper Company Crosslinked cellulose as precursor in production of high-grade cellulose derivatives and related technology
TWI727014B (zh) * 2016-03-24 2021-05-11 德商梅茲製藥有限兩合公司 修飾透明質酸與其製造方法及其用途
CN107880282B (zh) * 2016-12-29 2020-09-29 北京键凯科技股份有限公司 一种注射用多元甘醇环氧衍生物交联的透明质酸钠凝胶及其制备方法

Also Published As

Publication number Publication date
JP2022550778A (ja) 2022-12-05
MX2022003750A (es) 2022-05-02
JP7784138B2 (ja) 2025-12-11
EP4038105B1 (en) 2024-01-10
EP4038105C0 (en) 2024-01-10
KR20220075334A (ko) 2022-06-08
WO2021064006A1 (en) 2021-04-08
CN114502599A (zh) 2022-05-13
CN114502599B (zh) 2023-11-07
US20220380329A1 (en) 2022-12-01
EP4038105A1 (en) 2022-08-10
BR112022005786A2 (pt) 2022-06-21
ES2974643T3 (es) 2024-06-28
PL4038105T3 (pl) 2024-05-27

Similar Documents

Publication Publication Date Title
AR121176A1 (es) Un éter poliglicidílico de poliglicerol hiperramificado y su uso como reticulante de polisacáridos
BR112022013236A2 (pt) Anticorpos anti-cd73 e usos dos mesmos
BR122021004223A8 (pt) Molécula de anticorpo, composição, sequência de nucleotídeo, vetor, molécula de anticorpo e uso de uma molécula de anticorpo
BR112022006001A2 (pt) Imunoconjugado, composto de 8-amido-2-aminobenzazepina-ligante, composto de 5-amino-pirazoloazepina-ligante, composto de aminoquinolina-ligante, uso de um imunoconjugado e métodos para tratar câncer e para preparar um imunoconjugado
BR112022014667A2 (pt) Anticorpos de domínio único de cd28 e construtos multivalentes e multiespecíficos dos mesmos
PH12019502333A1 (en) Targeted compositions
BR112017009601A2 (pt) derivados de aminoácidos e seus usos
MX395142B (es) Marcadores selectivamente desregulados en celulas t reguladoras, infiltrantes de tumores.
BR112014014480A2 (pt) derivados de bisanidro-hexitol que contêm oxirano e usos dos mesmos
BR112018077362A2 (pt) conjugados para edição de superfície de célula-alvo
BR112022007719A2 (pt) Imunoconjugados, composto ligante, composição farmacêutica, método para tratar câncer, uso de um imunoconjugado e método de preparação de um imunoconjugado
BR112015019799A2 (pt) material híbrido orgânico-inorgânico, uso de um material híbrido orgânico-inorgânico e processo de recuperação do urânio(vi)
CO2024006160A2 (es) Conjugado de anticuerpo bispecífico-fármaco de camptotecina y uso farmacéutico de este
MX2021013251A (es) Tintes de cianina modificados y conjugados de los mismos.
MX2017010449A (es) Composiciones de polimeros reticulados con dos agentes reticulantes para su uso en operaciones en formaciones subterraneas.
BR112015001129A2 (pt) resinas com resistência a úmido de alta eficácia provenientes de novos reticuladores
EA202191123A1 (ru) Миниатюризированные дистрофины и их применения
BR112017027762A2 (pt) compostos de c,o-espiro aril glicosídeo, preparação para os mesmos e uso dos mesmos
EP4028018A4 (en) PHOSPHOLIPIDETHER CONJUGATES AS ANTI-CANCER CARRIERS
MX2018007723A (es) Composicion liquida para membrana de impermeabilizacion.
BR112016000844A8 (pt) compostos absorvedores de uv, composições que compreendem os mesmos, usos destes e método de proteger uma superfície ou tecido dos raios uv
BR112015024113A2 (pt) derivados de uréia e seu uso como inibidores da proteína de ligação de ácido graxo (fabp)
AR113857A1 (es) Compuestos de benzamida y su uso como herbicidas
BR112017019246A2 (pt) ?processo de preparação de poliuretano, poliuretano e usos de um composto e de poliuretano?
MX380217B (es) Agonistas del receptor cxcr3.

Legal Events

Date Code Title Description
FG Grant, registration