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AR120771A1 - Procedimiento de producción fermentativa de ácido guanidinoacético - Google Patents

Procedimiento de producción fermentativa de ácido guanidinoacético

Info

Publication number
AR120771A1
AR120771A1 ARP200103498A ARP200103498A AR120771A1 AR 120771 A1 AR120771 A1 AR 120771A1 AR P200103498 A ARP200103498 A AR P200103498A AR P200103498 A ARP200103498 A AR P200103498A AR 120771 A1 AR120771 A1 AR 120771A1
Authority
AR
Argentina
Prior art keywords
fermentative production
production procedure
guanidinoacetic acid
acid fermentative
gaa
Prior art date
Application number
ARP200103498A
Other languages
English (en)
Inventor
Schneider Frank Dr
Jankowitsch Frank Dr
Original Assignee
Evonik Operations Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Evonik Operations Gmbh filed Critical Evonik Operations Gmbh
Publication of AR120771A1 publication Critical patent/AR120771A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/78—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Pseudomonas
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/77—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Corynebacterium; for Brevibacterium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1003—Transferases (2.) transferring one-carbon groups (2.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/10—Citrulline; Arginine; Ornithine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y201/00—Transferases transferring one-carbon groups (2.1)
    • C12Y201/01—Methyltransferases (2.1.1)
    • C12Y201/01002—Guanidinoacetate N-methyltransferase (2.1.1.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y201/00—Transferases transferring one-carbon groups (2.1)
    • C12Y201/03—Carboxy- and carbamoyltransferases (2.1.3)
    • C12Y201/03003—Ornithine carbamoyltransferase (2.1.3.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y201/00—Transferases transferring one-carbon groups (2.1)
    • C12Y201/04—Amidinotransferases (2.1.4)
    • C12Y201/04001—Glycine amidinotransferase (2.1.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y403/00—Carbon-nitrogen lyases (4.3)
    • C12Y403/02—Amidine-lyases (4.3.2)
    • C12Y403/02001—Argininosuccinate lyase (4.3.2.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y603/00—Ligases forming carbon-nitrogen bonds (6.3)
    • C12Y603/04—Other carbon-nitrogen ligases (6.3.4)
    • C12Y603/04005—Argininosuccinate synthase (6.3.4.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y603/00—Ligases forming carbon-nitrogen bonds (6.3)
    • C12Y603/04—Other carbon-nitrogen ligases (6.3.4)
    • C12Y603/04016—Carbamoyl-phosphate synthase (ammonia) (6.3.4.16)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y603/00—Ligases forming carbon-nitrogen bonds (6.3)
    • C12Y603/05—Carbon-nitrogen ligases with glutamine as amido-N-donor (6.3.5)
    • C12Y603/05005—Carbamoyl-phosphate synthase (glutamine-hydrolysing) (6.3.5.5)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente se refiere a un microorganismo transformado para ser capaz de producir ácido guanidinoacético (GAA) y a un procedimiento de producción fermentativa de GAA usando tal microorganismo. La presente también se refiere a un procedimiento de producción fermentativa de creatina.
ARP200103498A 2019-12-19 2020-12-15 Procedimiento de producción fermentativa de ácido guanidinoacético AR120771A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP19218204.6A EP3839051A1 (en) 2019-12-19 2019-12-19 Method for the fermentative production of guanidinoacetic acid

Publications (1)

Publication Number Publication Date
AR120771A1 true AR120771A1 (es) 2022-03-16

Family

ID=69410969

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP200103498A AR120771A1 (es) 2019-12-19 2020-12-15 Procedimiento de producción fermentativa de ácido guanidinoacético

Country Status (17)

Country Link
US (1) US20250171790A1 (es)
EP (2) EP3839051A1 (es)
JP (1) JP7680454B2 (es)
KR (1) KR20220119026A (es)
CN (1) CN114867861A (es)
AR (1) AR120771A1 (es)
AU (1) AU2020410242A1 (es)
BR (1) BR112022010862A2 (es)
DK (1) DK4077695T3 (es)
IL (1) IL293952A (es)
MX (1) MX2022007250A (es)
MY (1) MY208731A (es)
PH (1) PH12022551505A1 (es)
PL (1) PL4077695T3 (es)
TW (1) TW202136505A (es)
WO (1) WO2021122400A1 (es)
ZA (1) ZA202207792B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3816247B1 (de) 2019-10-28 2022-12-07 Evonik Operations GmbH Härtermischung
CN113481139B (zh) * 2021-07-29 2022-11-08 江南大学 一种产胍基乙酸的重组枯草芽孢杆菌及其构建方法
JP2025518818A (ja) 2022-06-03 2025-06-19 エボニック オペレーションズ ゲーエムベーハー グアニジノ酢酸（ｇａａ）の生産のための方法
JP2025518819A (ja) 2022-06-03 2025-06-19 エボニック オペレーションズ ゲーエムベーハー Ｎａｄｈ依存性デヒドロゲナーゼを使用することによる、グアニジノ酢酸（ｇａａ）を生産するための改良されたバイオテクノロジーによる方法
CN120153067A (zh) 2022-11-03 2025-06-13 赢创运营有限公司 通过靶向引入或通过增加跨膜外向转运蛋白的活性获得的改进的生产胍基乙酸(gaa)的生物技术工艺
WO2024094483A1 (en) 2022-11-03 2024-05-10 Evonik Operations Gmbh Improved biotechnological process to produce guanidinoacetic acid (gaa) by targeted introduction or by increasing the activity of a transmembrane transport protein belonging to the amino acid-polyamine-organocation superfamily
CN120476203A (zh) 2023-01-09 2025-08-12 赢创运营有限公司 通过在微生物中减弱l-丝氨酸氨裂合酶活性来从丝氨酸发酵产生胍基乙酸（gaa）
EP4649144A1 (en) 2023-01-09 2025-11-19 Evonik Operations GmbH Fermentative production guanidinoacetic acid (gaa) from serine using a microorganism having an enhanced l-serine hydroxymethyltransferase activity
AU2024214542A1 (en) 2023-02-01 2025-09-11 Evonik Operations Gmbh Method for the fermentative production of guanidinoacetic acid using a microorganism comprising a heterologous l-threonine 3-dehydrogenase gene (tdh) and a glycine c-acetyltransferase gene (kbl)
EP4658777A1 (en) 2023-02-01 2025-12-10 Evonik Operations GmbH Method for the fermentative production of guanidinoacetic acid using a microorganism comprising a heterologous l-threonine aldolase gene
EP4662199A1 (en) 2023-02-06 2025-12-17 Evonik Operations GmbH Process for preparing an n-guanylamino acid
CN120641395A (zh) * 2023-02-06 2025-09-12 赢创运营有限公司 制备包含n-胍基氨基酸或由n-胍基氨基酸组成的自由流动颗粒的方法
CN116426497B (zh) * 2023-03-20 2023-10-13 江南大学 一种l-精氨酸-甘氨酸脒基转移酶及其在生产胍基乙酸中的应用
AU2024243877A1 (en) 2023-04-03 2025-11-06 Evonik Operations Gmbh Composition comprising an n-guanylamino acid for drinking water application
CN117625503B (zh) * 2023-11-20 2025-08-26 江南大学 一种利用微生物通过糖质原料发酵生产肌酸的方法

Family Cites Families (12)

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Publication number Priority date Publication date Assignee Title
US3849250A (en) 1971-02-26 1974-11-19 Kyowa Hakko Kogyo Kk Process for producing l-arginine by fermentation
US7393682B1 (en) * 1993-03-19 2008-07-01 The Johns Hopkins University School Of Medicine Polynucleotides encoding promyostatin polypeptides
DE60034843T2 (de) 1999-06-03 2008-01-17 Ajinomoto Co., Inc. Verfahren zur Herstellung von L-arginin
US7160705B2 (en) 2000-04-28 2007-01-09 Ajinomoto Co., Inc. Arginine repressor deficient strain of coryneform bacterium and method for producing L-arginine
ATE381892T1 (de) 2004-06-09 2008-01-15 Evonik Degussa Gmbh Guanidinoessigsäure als futtermittelzusatz
US20060200870A1 (en) * 2004-11-24 2006-09-07 Brian Tseng Methods of treating muscular dystrophy
JP4595506B2 (ja) * 2004-11-25 2010-12-08 味の素株式会社 Ｌ−アミノ酸生産菌及びｌ−アミノ酸の製造方法
ES2589378T3 (es) * 2008-04-10 2016-11-14 Korea Advanced Institute Of Science And Technology Microorganismo mutante con capacidad elevada para producir putrescina, y preparación de putrescina usando el mismo
KR101835935B1 (ko) 2014-10-13 2018-03-12 씨제이제일제당 (주) L-아르기닌을 생산하는 코리네박테리움 속 미생물 및 이를 이용한 l-아르기닌의 제조 방법
AU2016274311A1 (en) * 2015-06-10 2018-01-18 Synlogic Operating Company, Inc. Bacteria engineered to treat diseases associated with hyperammonemia
CN106065411B (zh) 2016-08-10 2021-12-07 洛阳华荣生物技术有限公司 发酵法生产肌酸
WO2018079687A1 (en) * 2016-10-26 2018-05-03 Ajinomoto Co., Inc. Method for producing objective substance

Also Published As

Publication number Publication date
MX2022007250A (es) 2022-07-13
WO2021122400A1 (en) 2021-06-24
EP4077695B1 (en) 2024-07-24
MY208731A (en) 2025-05-27
PL4077695T3 (pl) 2024-11-25
KR20220119026A (ko) 2022-08-26
CN114867861A (zh) 2022-08-05
AU2020410242A1 (en) 2022-08-11
BR112022010862A2 (pt) 2022-08-23
IL293952A (en) 2022-08-01
EP4077695A1 (en) 2022-10-26
JP7680454B2 (ja) 2025-05-20
EP3839051A1 (en) 2021-06-23
DK4077695T3 (da) 2024-10-14
JP2023507482A (ja) 2023-02-22
ZA202207792B (en) 2023-04-26
PH12022551505A1 (en) 2023-04-24
US20250171790A1 (en) 2025-05-29
TW202136505A (zh) 2021-10-01

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