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AR129893A1 - POLYPEPTIDES AND IMMUNOGENETIC VACCINES FOR HIV AND THEIR USES - Google Patents

POLYPEPTIDES AND IMMUNOGENETIC VACCINES FOR HIV AND THEIR USES

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Publication number
AR129893A1
AR129893A1 ARP230101814A ARP230101814A AR129893A1 AR 129893 A1 AR129893 A1 AR 129893A1 AR P230101814 A ARP230101814 A AR P230101814A AR P230101814 A ARP230101814 A AR P230101814A AR 129893 A1 AR129893 A1 AR 129893A1
Authority
AR
Argentina
Prior art keywords
seq
nos
polynucleotide
sequence
nucleic acid
Prior art date
Application number
ARP230101814A
Other languages
Spanish (es)
Inventor
Elena Bekerman
Jiani Li
Stephen R Martin
Devi Sengupta
Evguenia Svarovskaia
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of AR129893A1 publication Critical patent/AR129893A1/en

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La presente descripción se relaciona con polipéptidos inmunogénicos del VIH, polinucleótidos que codifican tales polipéptidos inmunogénicos del VIH, vectores de ARN mensajero (SAM) autoamplificantes que comprenden tales polinucleótidos, y vectores virales que comprenden tales polinucleótidos. Reivindicación 1: Un ARN autoamplificante (SAM o saRNA) que comprende: a. un polinucleótido que comprende una cualquiera de las secuencias de ácido nucleico de las SEQ ID Nº 522 - 523; b. un polinucleótido que comprende una secuencia de ácido nucleico que es al menos 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, o 100% idéntica a una cualquiera de las secuencias de ácidos nucleicos de las SEQ ID Nº 522 - 523, en donde el porcentaje de identidad está a lo largo de la longitud total de la secuencia de ácido nucleico de las SEQ ID Nº 522 - 523; c. un polinucleótido que comprende una cualquiera de las secuencias de ácido nucleico de las SEQ ID Nº 524 - 526; d. un polinucleótido que comprende una secuencia de ácido nucleico que es al menos 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, o 100% idéntica a una cualquiera de las secuencias de ácidos nucleicos de las SEQ ID Nº 524 - 526, en donde el porcentaje de identidad está a lo largo de la longitud total de la secuencia de ácido nucleico de las SEQ ID Nº 524 - 526; e. un polinucleótido que codifica una cualquiera de las secuencias de aminoácidos de las SEQ ID Nº 527 - 528; f. un polinucleótido que codifica un polipéptido que es al menos 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, o 100% idéntico a una cualquiera de las secuencias de aminoácidos de las SEQ ID Nº 527 - 528, en donde el porcentaje de identidad está a lo largo de la longitud total de la secuencia de aminoácidos de las SEQ ID Nº 527 - 528; g. (i) una primera secuencia de polinucleótidos que comprende nucleótidos 1 a 7512 de la SEQ ID Nº 522; (ii) una secuencia promotora; (iii) una segunda secuencia de polinucleótidos que comprende los nucleótidos 7537 a 7570 de la SEQ ID Nº 522; (iv) una tercera secuencia de polinucleótidos que codifica un polipéptido que comprende una secuencia de aminoácidos que es al menos 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98% o al menos 99% idéntica a la secuencia de aminoácidos de una cualquiera de las SEQ ID Nº 345 - 371, 373 - 377, 407 - 411, 422 - 423, 430 - 435, 527, y 528, en donde el porcentaje de identidad está a lo largo de la longitud total de las SEQ ID Nº 345 - 371, 373 - 377, 407 - 411, 422 - 423, 430 - 435, 527, y 528; (v) una cuarta secuencia de polinucleótidos que comprende nucleótidos 10667 a 10952 de la SEQ ID Nº 522; y (vi) una región de poliA; o h. (i) una primera secuencia de polinucleótidos que comprende nucleótidos 1 a 7512 de la SEQ ID Nº 522; (ii) una secuencia promotora; (iii) una segunda secuencia de polinucleótidos que comprende los nucleótidos 7537 a 7570 de la SEQ ID Nº 522; (iv) una tercera secuencia de polinucleótidos que codifica uno o más segmentos de polipéptido, en donde el uno o más segmentos de polipéptido comprenden una secuencia de aminoácidos que es al menos 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98% o al menos 99% idéntica a la secuencia de aminoácidos de una cualquiera de las SEQ ID Nº 1 - 344, en donde el porcentaje de identidad está a lo largo de la longitud total de las SEQ ID Nº 1 - 344; (v) una cuarta secuencia de polinucleótidos que comprende nucleótidos 10667 a 10952 de la SEQ ID Nº 522; y (vi) una región de poliA. Reivindicación 15: Una nanopartícula polimérica (PNP) que comprende el SAM de una cualquiera de las reivindicaciones 1 a 7, o el casete de expresión de una cualquiera de las reivindicaciones 8 a 11. Reivindicación 20: Una nanoemulsión que comprende el SAM de una cualquiera de las reivindicaciones 1 a 7, o el casete de expresión de una cualquiera de las reivindicaciones 8 a 11. Reivindicación 23: Un vector de expresión que comprende el SAM de una cualquiera de las reivindicaciones 1 a 7, o el casete de expresión de una cualquiera de las reivindicaciones 8 a 10.The present disclosure relates to HIV immunogenic polypeptides, polynucleotides encoding such HIV immunogenic polypeptides, self-amplifying messenger RNA (SAM) vectors comprising such polynucleotides, and viral vectors comprising such polynucleotides. Claim 1: A self-amplifying RNA (SAM or saRNA) comprising: a. a polynucleotide comprising any one of the nucleic acid sequences of SEQ ID NO: 522 - 523; b. a polynucleotide comprising a nucleic acid sequence that is at least 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to any one of the nucleic acid sequences of SEQ ID NOs: 522-523, wherein the percent identity is over the entire length of the nucleic acid sequence of SEQ ID NOs: 522-523; c. a polynucleotide comprising any one of the nucleic acid sequences of SEQ ID NOs: 524-526; d. a polynucleotide comprising a nucleic acid sequence that is at least 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to any one of the nucleic acid sequences of SEQ ID NOs: 524-526, wherein the percent identity is over the entire length of the nucleic acid sequence of SEQ ID NOs: 524-526; e. a polynucleotide encoding any one of the amino acid sequences of SEQ ID NOs: 527-528; f. a polynucleotide encoding a polypeptide that is at least 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to any one of the amino acid sequences of SEQ ID NOs: 527-528, wherein the percent identity is over the entire length of the amino acid sequence of SEQ ID NOs: 527-528; g. (i) a first polynucleotide sequence comprising nucleotides 1 to 7512 of SEQ ID NO: 522; (ii) a promoter sequence; (iii) a second polynucleotide sequence comprising nucleotides 7537 to 7570 of SEQ ID No. 522; (iv) a third polynucleotide sequence encoding a polypeptide comprising an amino acid sequence that is at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or at least 99% identical to the amino acid sequence of any one of SEQ ID NOs: 345-371, 373-377, 407-411, 422-423, 430-435, 527, and 528, wherein the percent identity is over the entire length of SEQ ID NOs: 345-371, 373-377, 407-411, 422-423, 430-435, 527, and 528; (v) a fourth polynucleotide sequence comprising nucleotides 10667 to 10952 of SEQ ID NO: 522; and (vi) a polyA region; or h. (i) a first polynucleotide sequence comprising nucleotides 1 to 7512 of SEQ ID NO: 522; (ii) a promoter sequence; (iii) a second polynucleotide sequence comprising nucleotides 7537 to 7570 of SEQ ID NO: 522; (iv) a third polynucleotide sequence encoding one or more polypeptide segments, wherein the one or more polypeptide segments comprise an amino acid sequence that is at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or at least 99% identical to the amino acid sequence of any one of SEQ ID NOs: 1-344, wherein the percent identity is over the entire length of SEQ ID NOs: 1-344; (v) a fourth polynucleotide sequence comprising nucleotides 10667 to 10952 of SEQ ID NO: 522; and (vi) a polyA region. Claim 15: A polymeric nanoparticle (PNP) comprising the SAM of any one of claims 1 to 7, or the expression cassette of any one of claims 8 to 11. Claim 20: A nanoemulsion comprising the SAM of any one of claims 1 to 7, or the expression cassette of any one of claims 8 to 11. Claim 23: An expression vector comprising the SAM of any one of claims 1 to 7, or the expression cassette of any one of claims 8 to 10.

ARP230101814A 2020-02-15 2023-07-11 POLYPEPTIDES AND IMMUNOGENETIC VACCINES FOR HIV AND THEIR USES AR129893A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063485122P 2020-02-15 2020-02-15
US202063384020P 2020-11-16 2020-11-16
US202263388599P 2022-07-12 2022-07-12

Publications (1)

Publication Number Publication Date
AR129893A1 true AR129893A1 (en) 2024-10-09

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ID=93378764

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP230101814A AR129893A1 (en) 2020-02-15 2023-07-11 POLYPEPTIDES AND IMMUNOGENETIC VACCINES FOR HIV AND THEIR USES

Country Status (1)

Country Link
AR (1) AR129893A1 (en)

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