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AR129556A1 - Compuestos químicos - Google Patents

Compuestos químicos

Info

Publication number
AR129556A1
AR129556A1 ARP230101456A ARP230101456A AR129556A1 AR 129556 A1 AR129556 A1 AR 129556A1 AR P230101456 A ARP230101456 A AR P230101456A AR P230101456 A ARP230101456 A AR P230101456A AR 129556 A1 AR129556 A1 AR 129556A1
Authority
AR
Argentina
Prior art keywords
pharmaceutically acceptable
group
acceptable salt
compound
tautomer
Prior art date
Application number
ARP230101456A
Other languages
English (en)
Inventor
Jie Guang
Jay M Matthews
Alan T Price
Jared Troy Spletstoser
Original Assignee
Glaxosmithkline Ip Dev Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Ip Dev Ltd filed Critical Glaxosmithkline Ip Dev Ltd
Publication of AR129556A1 publication Critical patent/AR129556A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • A61K31/675Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Dermatology (AREA)

Abstract

Se proporcionan compuestos y composiciones farmacéuticas y usos de estos para inhibir canales de iones sodio dependientes del voltaje Naᵛ1.8 y tratar enfermedades mediadas por Naᵛ1.8, tales como dolor y enfermedades asociadas al dolor, y enfermedades cardiovasculares. Reivindicación 1: Un compuesto seleccionado del grupo que consiste en: el grupo de fórmulas (1), o una sal farmacéuticamente aceptable de este. Reivindicación 8: Un compuesto seleccionado del grupo que consiste en: el grupo de fórmulas (2), o un tautómero de este, o una sal farmacéuticamente aceptable de este. Reivindicación 9: Una composición farmacéutica caracterizada porque comprende el compuesto o sal farmacéuticamente aceptable de este según una cualquiera de las reivindicaciones 1 a 7, y un excipiente farmacéuticamente aceptable. Reivindicación 10: Una composición farmacéutica caracterizada porque comprende el compuesto, o tautómero de este, o sal farmacéuticamente aceptable de este según la reivindicación 8, y un excipiente farmacéuticamente aceptable.
ARP230101456A 2022-06-09 2023-06-07 Compuestos químicos AR129556A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US202263350640P 2022-06-09 2022-06-09

Publications (1)

Publication Number Publication Date
AR129556A1 true AR129556A1 (es) 2024-09-04

Family

ID=87074597

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP230101456A AR129556A1 (es) 2022-06-09 2023-06-07 Compuestos químicos

Country Status (14)

Country Link
US (1) US20230416287A1 (es)
EP (1) EP4536673A1 (es)
JP (1) JP2025519523A (es)
KR (1) KR20250022122A (es)
CN (1) CN119365473A (es)
AR (1) AR129556A1 (es)
AU (1) AU2023284137A1 (es)
CA (1) CA3258570A1 (es)
CL (1) CL2024003739A1 (es)
CO (1) CO2025000063A2 (es)
IL (1) IL317272A (es)
MX (1) MX2024015095A (es)
TW (1) TWI867570B (es)
WO (1) WO2023238064A1 (es)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201604477SA (en) * 2013-12-13 2016-07-28 Vertex Pharma Prodrugs of pyridone amides useful as modulators of sodium channels
US20230103791A1 (en) 2019-06-27 2023-04-06 Glaxosmithkline Intellectual Property Development Limited 2,3-dihydroquinazolin compounds as nav1.8 inhibitors

Also Published As

Publication number Publication date
JP2025519523A (ja) 2025-06-26
WO2023238064A1 (en) 2023-12-14
CL2024003739A1 (es) 2025-04-21
TW202415383A (zh) 2024-04-16
KR20250022122A (ko) 2025-02-14
AU2023284137A1 (en) 2024-12-05
CO2025000063A2 (es) 2025-01-23
EP4536673A1 (en) 2025-04-16
CA3258570A1 (en) 2023-12-14
TWI867570B (zh) 2024-12-21
CN119365473A (zh) 2025-01-24
US20230416287A1 (en) 2023-12-28
MX2024015095A (es) 2025-01-09
IL317272A (en) 2025-01-01

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