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AR127582A1 - METHODS FOR THE TREATMENT OF CANCER - Google Patents

METHODS FOR THE TREATMENT OF CANCER

Info

Publication number
AR127582A1
AR127582A1 ARP220103034A ARP220103034A AR127582A1 AR 127582 A1 AR127582 A1 AR 127582A1 AR P220103034 A ARP220103034 A AR P220103034A AR P220103034 A ARP220103034 A AR P220103034A AR 127582 A1 AR127582 A1 AR 127582A1
Authority
AR
Argentina
Prior art keywords
salt
compound
treatment
cancer
suppression
Prior art date
Application number
ARP220103034A
Other languages
Spanish (es)
Inventor
Snahel Patel
Hiroko Tanaka
Daniel A Erlanson
Philip A Gerken
John C Widen
Monika Jane Williams
Irina DOTSENKO
Original Assignee
Frontier Medicines Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Frontier Medicines Corp filed Critical Frontier Medicines Corp
Publication of AR127582A1 publication Critical patent/AR127582A1/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente descripción proporciona compuestos y métodos útiles para el tratamiento y la supresión del cáncer, por ejemplo, útiles para el tratamiento o la supresión de cánceres caracterizados por KRAS G12C. También se proporcionan composiciones farmacéuticas que contienen estos compuestos y procesos para la preparación de estos compuestos. Un compuesto de la fórmula (1) o la fórmula (2). Reivindicación 111: Una formulación farmacéutica que comprende el compuesto de cualquiera de las reivindicaciones 1 - 109, donde, cuando el compuesto es una sal, la sal es una sal farmacéuticamente aceptable, y un portador farmacéuticamente aceptable. Reivindicación 112: Un método para el tratamiento o la supresión del cáncer que comprende: administrarle a un sujeto que lo necesite una cantidad terapéuticamente eficaz de un compuesto de cualquiera de las reivindicaciones 1 - 109, donde, cuando el compuesto es una sal, la sal es una sal farmacéuticamente aceptable, o una formulación farmacéutica de acuerdo con la reivindicación 111. Reivindicación 113: Un compuesto de cualquiera de las reivindicaciones 1 - 109 o una formulación farmacéutica de acuerdo con la reivindicación 111 para utilizar en el tratamiento o la supresión del cáncer, donde, cuando el compuesto es una sal, la sal es una sal farmacéuticamente aceptable.The present disclosure provides compounds and methods useful for the treatment and suppression of cancer, for example, useful for the treatment or suppression of cancers characterized by KRAS G12C. Also provided are pharmaceutical compositions containing these compounds and processes for the preparation of these compounds. A compound of formula (1) or formula (2). Claim 111: A pharmaceutical formulation comprising the compound of any of claims 1 - 109, wherein, when the compound is a salt, the salt is a pharmaceutically acceptable salt, and a pharmaceutically acceptable carrier. Claim 112: A method for the treatment or suppression of cancer comprising: administering to a subject in need thereof a therapeutically effective amount of a compound of any of claims 1 - 109, wherein, when the compound is a salt, the salt is a pharmaceutically acceptable salt, or a pharmaceutical formulation according to claim 111. Claim 113: A compound of any of claims 1 - 109 or a pharmaceutical formulation according to claim 111 for use in the treatment or suppression of cancer , where, when the compound is a salt, the salt is a pharmaceutically acceptable salt.

ARP220103034A 2020-06-29 2022-11-04 METHODS FOR THE TREATMENT OF CANCER AR127582A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063356906P 2020-06-29 2020-06-29
US202063403565P 2020-09-02 2020-09-02
US202163276478P 2021-11-05 2021-11-05

Publications (1)

Publication Number Publication Date
AR127582A1 true AR127582A1 (en) 2024-02-07

Family

ID=90220616

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP220103034A AR127582A1 (en) 2020-06-29 2022-11-04 METHODS FOR THE TREATMENT OF CANCER

Country Status (1)

Country Link
AR (1) AR127582A1 (en)

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