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AR127344A2 - Conjugados anticuerpo-fármaco que comprenden agonistas de sting - Google Patents

Conjugados anticuerpo-fármaco que comprenden agonistas de sting

Info

Publication number
AR127344A2
AR127344A2 ARP220102777A ARP220102777A AR127344A2 AR 127344 A2 AR127344 A2 AR 127344A2 AR P220102777 A ARP220102777 A AR P220102777A AR P220102777 A ARP220102777 A AR P220102777A AR 127344 A2 AR127344 A2 AR 127344A2
Authority
AR
Argentina
Prior art keywords
conjugate
seq
amino acid
acid sequence
complementarity determining
Prior art date
Application number
ARP220102777A
Other languages
English (en)
Inventor
Jeremy R Duvall
Keith W Bentley
Raghida A Bukhalid
Naniye Cetinbas
Marc I Damelin
Eugene W Kelleher
Dorin Toader
Ling Xu
Liping Yang
Joshua D Thomas
Timothy B Lowinger
Original Assignee
Mersana Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mersana Therapeutics Inc filed Critical Mersana Therapeutics Inc
Publication of AR127344A2 publication Critical patent/AR127344A2/es

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  • Pulmonology (AREA)

Abstract

Un conjugado anticuerpo-fármaco (ADC) que es: de fórmula (1); o una sal farmacéuticamente aceptables de éste, donde el conjugado comprende el anticuerpo XMT-1519 que comprende una región de determinación de complementariedad de cadena pesada variable 1 (CDRH1) que comprende la secuencia de aminoácidos FTFSSYSMN (SEQ ID Nº 20); una región de determinación de complementariedad de cadena pesada variable 2 (CDRH2) que comprende la secuencia de aminoácidos YISSSSSTIYYADSVKG (SEQ ID Nº 21); una región de determinación de complementariedad de cadena pesada variable 3 (CDRH3) que comprende la secuencia de aminoácidos GGHGYFDL (SEQ ID Nº 22); y una región de determinación de complementariedad de cadena liviana variable 1 (CDRL1) que comprende una secuencia de aminoácidos RASQSVSSSYLA (SEQ ID Nº 27); una región de determinación de complementariedad de cadena liviana variable 2 (CDRL2) que comprende la secuencia de aminoácidos GASSRAT (SEQ ID Nº 28); y una región de determinación de complementariedad de cadena liviana variable 3 (CDRL3) que comprende la secuencia de aminoácidos QQYHHSPLT (SEQ ID Nº 29), y d₁₅ representa un entero comprendido en un rango entre aproximadamente 1 y aproximadamente 20. Composición farmacéutica que comprende dicho conjugado y uno o más vehículos o excipientes farmacéuticamente aceptables. Método de tratamiento, el conjugado para uso o uso del conjugado para prevenir o tratar una enfermedad o trastorno en un sujeto. La enfermedad o trastorno está asociada con el agonista de STING. Método de tratamiento, el conjugado para uso o uso del conjugado para prevenir o tratar una enfermedad o trastorno en un sujeto donde la enfermedad o trastorno es cáncer.
ARP220102777A 2020-04-02 2022-10-12 Conjugados anticuerpo-fármaco que comprenden agonistas de sting AR127344A2 (es)

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