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AR127056A1 - HUMAN MONOCARBOXYLATE TRANSPORTER 1 ANTIBODIES AND USES OF THESE - Google Patents

HUMAN MONOCARBOXYLATE TRANSPORTER 1 ANTIBODIES AND USES OF THESE

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Publication number
AR127056A1
AR127056A1 ARP220102485A ARP220102485A AR127056A1 AR 127056 A1 AR127056 A1 AR 127056A1 AR P220102485 A ARP220102485 A AR P220102485A AR P220102485 A ARP220102485 A AR P220102485A AR 127056 A1 AR127056 A1 AR 127056A1
Authority
AR
Argentina
Prior art keywords
antibody
antibodies
comprises seq
seq
vector
Prior art date
Application number
ARP220102485A
Other languages
Spanish (es)
Inventor
Frank Charles Dorsey
Joseph Benjamin Granger
Kira Vladimirovna Rubtsova
Oliver Schroeder
Wei Wang
Original Assignee
Immunometabolism Dev Company Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunometabolism Dev Company Llc filed Critical Immunometabolism Dev Company Llc
Publication of AR127056A1 publication Critical patent/AR127056A1/en

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  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La presente invención se refiere a anticuerpos que se unen específicamente al transportador de monocarboxilato humano 1 (MCT1) (“anticuerpos anti-MCT1 humano”), composiciones que comprenden dichos anticuerpos anti-MCT1 humano y métodos para usar dichos anticuerpos anti-MCT1 humano. Reivindicación 1: Un anticuerpo o fragmento de unión a antígeno de este que se une específicamente a MCT1 humano, en donde el anticuerpo comprende una región variable de cadena pesada (VH) y una región variable de cadena ligera (VL), en donde la VH comprende regiones determinantes de complementariedad de cadena pesada HCDR1, HCDR2 y HCDR3, y la VL comprende regiones determinantes de complementariedad de cadena ligera LCDR1, LCDR2 y LCDR3, en donde: la HCDR1 comprende la SEQ ID Nº 30; la HCDR2 comprende la SEQ ID Nº 31; la HCDR3 comprende la SEQ ID Nº 32; la LCDR1 comprende la SEQ ID Nº 33; la LCDR2 comprende la SEQ ID Nº 5; y la LCDR3 comprende la SEQ ID Nº 6. Reivindicación 27: Un ácido nucleico que comprende una secuencia que codifica la SEQ ID Nº 9, 19, 23, 28, 36, 42, 46, 50, 54, 58, 62, 66, 70, 74, 78, 82, 86, 90, 10, 15, 24, o 37. Reivindicación 28: Un vector que comprende el ácido nucleico de la Reivindicación 27. Reivindicación 33: Una composición que comprende un primer vector que comprende una secuencia de ácido nucleico que codifica la SEQ ID Nº 9, 70, o 74, y un segundo vector que comprende una secuencia de ácido nucleico que codifica la SEQ ID Nº 10. Reivindicación 37: Una célula que comprende el vector de una cualquiera de las Reivindicaciones 28 - 36. Reivindicación 43: Un proceso para producir un anticuerpo que comprende cultivar la célula de una cualquiera de las Reivindicaciones 38 - 41 en condiciones tales que el anticuerpo se expresa y recuperar el anticuerpo expresado del medio de cultivo. Reivindicación 46: Un método para inhibir la actividad o la cantidad de células T efectoras o células B en un sujeto que lo necesite que comprende administrar al sujeto una cantidad terapéuticamente eficaz del anticuerpo de una cualquiera de las Reivindicaciones 1 - 26 o 44, o la composición farmacéutica de la reivindicación 45. Reivindicación 47: Un método para aumentar la actividad o la cantidad de células T reguladoras en un sujeto que lo necesite que comprende administrar al sujeto una cantidad terapéuticamente eficaz del anticuerpo de una cualquiera de las Reivindicaciones 1 - 26 o 44, o la composición farmacéutica de la reivindicación 45.The present invention relates to antibodies that specifically bind to human monocarboxylate transporter 1 (MCT1) ('anti-human MCT1 antibodies'), compositions comprising said anti-human MCT1 antibodies, and methods of using said anti-human MCT1 antibodies. Claim 1: An antibody or antigen-binding fragment thereof that specifically binds to human MCT1, wherein the antibody comprises a heavy chain variable region (VH) and a light chain variable region (VL), wherein the VH comprises HCDR1, HCDR2 and HCDR3 heavy chain complementarity determining regions, and the VL comprises LCDR1, LCDR2 and LCDR3 light chain complementarity determining regions, wherein: HCDR1 comprises SEQ ID NO: 30; HCDR2 comprises SEQ ID NO: 31; HCDR3 comprises SEQ ID NO: 32; LCDR1 comprises SEQ ID NO: 33; LCDR2 comprises SEQ ID NO: 5; and LCDR3 comprises SEQ ID NO: 6. Claim 27: A nucleic acid comprising a sequence encoding SEQ ID NO: 9, 19, 23, 28, 36, 42, 46, 50, 54, 58, 62, 66, 70, 74, 78, 82, 86, 90, 10, 15, 24, or 37. Claim 28: A vector comprising the nucleic acid of Claim 27. Claim 33: A composition comprising a first vector comprising a sequence of nucleic acid encoding SEQ ID NO: 9, 70, or 74, and a second vector comprising a nucleic acid sequence encoding SEQ ID NO: 10. Claim 37: A cell comprising the vector of any one of Claims 28-36. Claim 43: A process for producing an antibody comprising culturing the cell of any one of Claims 38-41 under conditions such that the antibody is expressed and recovering the expressed antibody from the culture medium. Claim 46: A method of inhibiting the activity or quantity of effector T cells or B cells in a subject in need thereof comprising administering to the subject a therapeutically effective amount of the antibody of any one of Claims 1 - 26 or 44, or pharmaceutical composition of claim 45. Claim 47: A method of increasing the activity or quantity of regulatory T cells in a subject in need thereof comprising administering to the subject a therapeutically effective amount of the antibody of any one of Claims 1 - 26 or 44, or the pharmaceutical composition of claim 45.

ARP220102485A 2020-10-28 2022-09-13 HUMAN MONOCARBOXYLATE TRANSPORTER 1 ANTIBODIES AND USES OF THESE AR127056A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063272903P 2020-10-28 2020-10-28
US202163261177P 2021-09-14 2021-09-14

Publications (1)

Publication Number Publication Date
AR127056A1 true AR127056A1 (en) 2023-12-13

Family

ID=89309915

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP220102485A AR127056A1 (en) 2020-10-28 2022-09-13 HUMAN MONOCARBOXYLATE TRANSPORTER 1 ANTIBODIES AND USES OF THESE

Country Status (1)

Country Link
AR (1) AR127056A1 (en)

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