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AR126239A1 - Región 5’ no traducida y región 3’ no traducida no naturales y uso de estas - Google Patents

Región 5’ no traducida y región 3’ no traducida no naturales y uso de estas

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Publication number
AR126239A1
AR126239A1 ARP220101665A ARP220101665A AR126239A1 AR 126239 A1 AR126239 A1 AR 126239A1 AR P220101665 A ARP220101665 A AR P220101665A AR P220101665 A ARP220101665 A AR P220101665A AR 126239 A1 AR126239 A1 AR 126239A1
Authority
AR
Argentina
Prior art keywords
natural
region
untranslated
untranslated region
utr
Prior art date
Application number
ARP220101665A
Other languages
English (en)
Inventor
Seung Su Han
Da Hyeon Park
Euh Lim Oh
Yong Ho Heo
Jin Bong Lee
Joo Young Dong
Seungu Hyun Shin
Chang Gyu Lim
Original Assignee
Hanmi Pharm Ind Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hanmi Pharm Ind Co Ltd filed Critical Hanmi Pharm Ind Co Ltd
Publication of AR126239A1 publication Critical patent/AR126239A1/es

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/335—Modified T or U
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    • C12N2770/00011—Details
    • C12N2770/20011—Coronaviridae
    • C12N2770/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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    • C12N2770/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/50—Vector systems having a special element relevant for transcription regulating RNA stability, not being an intron, e.g. poly A signal

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Se proporcionan una región 5’ no traducida y una región 3’ no traducida no naturales y un uso de estas. Reivindicación 1: Un polinucleótido aislado, que es un polidesoxirribonucleótido, que comprende: una secuencia de nucleótidos que codifica una región 5’ no traducida (5’-UTR) no natural, una secuencia de nucleótidos que codifica una región 3’ no traducida (3’-UTR), o una combinación de estas. Reivindicación 19: Un polinucleótido aislado, que es un polirribonucleótido, que comprende: una secuencia de nucleótidos de una región 5’ no traducida (5’-UTR) no natural, una secuencia de nucleótidos de una región 3’ no traducida (3’-UTR), o una combinación de estas. Reivindicación 34: Una composición para suministrar un polipéptido a un sujeto, en donde la composición comprende un polinucleótido de una cualquiera de las reivindicaciones 19 a 33 como principio activo.
ARP220101665A 2021-06-24 2022-06-24 Región 5’ no traducida y región 3’ no traducida no naturales y uso de estas AR126239A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20210082600 2021-06-24
KR20210185375 2021-12-22

Publications (1)

Publication Number Publication Date
AR126239A1 true AR126239A1 (es) 2023-10-04

Family

ID=84544655

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP220101665A AR126239A1 (es) 2021-06-24 2022-06-24 Región 5’ no traducida y región 3’ no traducida no naturales y uso de estas

Country Status (11)

Country Link
US (1) US20240301433A1 (es)
EP (1) EP4361270A4 (es)
JP (1) JP2024528447A (es)
KR (1) KR20230000471A (es)
AR (1) AR126239A1 (es)
AU (1) AU2022297171A1 (es)
CA (1) CA3223855A1 (es)
IL (1) IL309530A (es)
MX (1) MX2023015487A (es)
TW (1) TW202317766A (es)
WO (1) WO2022270969A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025014191A1 (ko) * 2023-07-07 2025-01-16 에스케이바이오사이언스(주) 단백질 발현을 위한 rna 및 이를 위한 주형
KR20250047489A (ko) * 2023-09-27 2025-04-04 한미약품 주식회사 변형된 폴리아데닐 서열 및 p53 단백질 코딩서열을 포함하는 핵산 분자
KR20250047490A (ko) * 2023-09-27 2025-04-04 한미약품 주식회사 변형된 폴리아데닐 서열 및 ox40l 단백질 코딩서열을 포함하는 핵산 분자
AR133966A1 (es) * 2023-09-27 2025-11-19 Hanmi Pharmaceutical Co Ltd UNA COMPOSICIÓN FARMACÉUTICA PARA PREVENIR O TRATAR EL CÁNCER QUE INCLUYE UN CONSTRUCTO DE ÁCIDO NUCLEICO QUE CODIFICA LA PROTEÍNA p53
TW202516015A (zh) * 2023-09-27 2025-04-16 南韓商韓美藥品股份有限公司 包括非天然３’非轉譯區的傳訊核糖核酸、對其進行編碼的脫氧核糖核酸以及包含其的組成物
WO2025071333A1 (ko) * 2023-09-27 2025-04-03 한미약품 주식회사 비천연 5'비번역 영역 및 그의 용도
KR20250063952A (ko) * 2023-10-30 2025-05-09 주식회사 녹십자 번역 효율이 향상된 3'-utr, 이를 포함하는 합성 핵산 분자 및 이를 포함하는 백신 또는 치료제 조성물
WO2025110722A1 (ko) * 2023-11-20 2025-05-30 한국생명공학연구원 단백질 번역 효율 향상용 mRNA 구조체 및 이의 용도
CN117535295B (zh) * 2024-01-09 2024-04-26 艾斯拓康医药科技(北京)有限公司 一种优化的3`utr序列及其应用
CN118421633B (zh) * 2024-07-02 2024-10-18 深圳新合睿恩生物医疗科技有限公司 高效表达的mRNA的5'UTR序列及其应用

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7423139B2 (en) * 2004-01-20 2008-09-09 Insight Biopharmaceuticals Ltd. High level expression of recombinant human erythropoietin having a modified 5′-UTR
SMT202200337T1 (it) * 2012-11-26 2022-09-14 Modernatx Inc Rna modificato al livello del terminale
US20160022840A1 (en) * 2013-03-09 2016-01-28 Moderna Therapeutics, Inc. Heterologous untranslated regions for mrna
US20170202979A1 (en) * 2014-07-17 2017-07-20 Modernatx, Inc. Terminal modifications of polynucleotides
CN107124889A (zh) * 2014-12-30 2017-09-01 库瑞瓦格股份公司 人工核酸分子
JP7304155B2 (ja) * 2015-08-28 2023-07-06 キュアバック エスイー 人工核酸分子
WO2017059902A1 (en) * 2015-10-07 2017-04-13 Biontech Rna Pharmaceuticals Gmbh 3' utr sequences for stabilization of rna
WO2018213789A1 (en) * 2017-05-18 2018-11-22 Modernatx, Inc. Modified messenger rna comprising functional rna elements
WO2018222890A1 (en) * 2017-05-31 2018-12-06 Arcturus Therapeutics, Inc. Synthesis and structure of high potency rna therapeutics

Also Published As

Publication number Publication date
TW202317766A (zh) 2023-05-01
US20240301433A1 (en) 2024-09-12
MX2023015487A (es) 2024-04-10
EP4361270A1 (en) 2024-05-01
WO2022270969A1 (ko) 2022-12-29
AU2022297171A1 (en) 2024-01-18
JP2024528447A (ja) 2024-07-30
KR20230000471A (ko) 2023-01-02
IL309530A (en) 2024-02-01
CA3223855A1 (en) 2022-12-29
EP4361270A4 (en) 2025-05-21

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