[go: up one dir, main page]

AR125379A1 - Un fab anti-tslp con estabilidad mejorada - Google Patents

Un fab anti-tslp con estabilidad mejorada

Info

Publication number
AR125379A1
AR125379A1 ARP220101003A ARP220101003A AR125379A1 AR 125379 A1 AR125379 A1 AR 125379A1 AR P220101003 A ARP220101003 A AR P220101003A AR P220101003 A ARP220101003 A AR P220101003A AR 125379 A1 AR125379 A1 AR 125379A1
Authority
AR
Argentina
Prior art keywords
fab
tslp
vector
improved stability
nucleic acid
Prior art date
Application number
ARP220101003A
Other languages
English (en)
Inventor
Roland Wilhelm Kolbeck
Emma Suzanne Cohen
Catherine Eugenie Huntington
Original Assignee
Medimmune Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medimmune Ltd filed Critical Medimmune Ltd
Publication of AR125379A1 publication Critical patent/AR125379A1/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244Interleukins [IL]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52Constant or Fc region; Isotype
    • C07K2317/522CH1 domain
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55Fab or Fab'
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Cosmetics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La presente divulgación se refiere a un Fab anti-TSLP con estabilidad mejorada, a ácidos nucleicos que codifican dicho Fab, a células hospedadoras y a un vector que comprende dichos ácidos nucleicos, y a métodos para utilizar dicho Fab en el tratamiento de afecciones relacionadas con la TSLP. Reivindicación 1: Un Fab que comprende una cadena pesada que comprende la secuencia de aminoácidos expuesta en la SEQ ID Nº 1 y una cadena ligera que comprende la secuencia de aminoácidos expuesta en la SEQ ID Nº 2. Reivindicación 8: Una composición farmacéutica que comprende el Fab de una cualquiera de las reivindicaciones 1 a 7. Reivindicación 9: Un ácido nucleico que codifica el Fab de cualquiera de las reivindicaciones 1 a 7. Reivindicación 10: Un vector que comprende el ácido nucleico de la reivindicación 9. Reivindicación 11: Una célula hospedadora que comprende el ácido nucleico de la reivindicación 9 o el vector de la reivindicación 10.
ARP220101003A 2021-04-19 2022-04-19 Un fab anti-tslp con estabilidad mejorada AR125379A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP21169183 2021-04-19

Publications (1)

Publication Number Publication Date
AR125379A1 true AR125379A1 (es) 2023-07-12

Family

ID=75588042

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP220101003A AR125379A1 (es) 2021-04-19 2022-04-19 Un fab anti-tslp con estabilidad mejorada

Country Status (19)

Country Link
US (1) US20240199730A1 (es)
EP (1) EP4326767A1 (es)
JP (1) JP2024516962A (es)
KR (1) KR20230172508A (es)
CN (1) CN117222665A (es)
AR (1) AR125379A1 (es)
AU (1) AU2022263281A1 (es)
BR (1) BR112023021587A2 (es)
CA (1) CA3216894A1 (es)
CL (1) CL2023003082A1 (es)
CO (1) CO2023015286A2 (es)
CR (1) CR20230533A (es)
EC (1) ECSP23086870A (es)
IL (1) IL307651A (es)
MX (1) MX2023012266A (es)
PH (1) PH12023552762A1 (es)
SA (1) SA523451188B1 (es)
TW (1) TW202306982A (es)
WO (1) WO2022223514A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE071069T2 (hu) * 2019-10-28 2025-07-28 Medimmune Ltd Tímusz sztrómális limfopoietint (TSLP) kötõ antitestek szárazpor készítményei és eljárások ezek alkalmazására
US12110324B2 (en) 2022-07-22 2024-10-08 Flagship Pioneering Innovations Vi, Llc Antigen binding molecules targeting thymic stromal lymphopoietin (TSLP)
WO2025163008A1 (en) 2024-01-29 2025-08-07 Astrazeneca Ab Compositions of thymic stromal lymphopoietin (tslp) binding fragments and methods of use thereof
WO2025242605A1 (en) 2024-05-20 2025-11-27 Medimmune Limited Inhaler and capsule for delivering thymic stromal lymphopoietin (tslp)-binding antibodies

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1340088B1 (en) 2000-11-17 2007-01-17 University Of Rochester In vitro methods of producing and identifying immunoglobulin molecules in eukaryotic cells
AU2002327164A1 (en) 2001-01-29 2002-12-09 Idec Pharmaceuticals Corporation Engineered tetravalent antibodies and methods of use
JOP20190243A1 (ar) * 2017-04-12 2019-10-13 Medimmune Llc علاج الربو بجسم مضاد لـ tslp
WO2021043221A1 (en) * 2019-09-04 2021-03-11 Biosion Inc. Antibodies binding tslp and uses thereof
HUE071069T2 (hu) * 2019-10-28 2025-07-28 Medimmune Ltd Tímusz sztrómális limfopoietint (TSLP) kötõ antitestek szárazpor készítményei és eljárások ezek alkalmazására

Also Published As

Publication number Publication date
CL2023003082A1 (es) 2024-04-19
MX2023012266A (es) 2023-10-24
IL307651A (en) 2023-12-01
WO2022223514A1 (en) 2022-10-27
CN117222665A (zh) 2023-12-12
KR20230172508A (ko) 2023-12-22
SA523451188B1 (ar) 2025-06-22
JP2024516962A (ja) 2024-04-18
US20240199730A1 (en) 2024-06-20
ECSP23086870A (es) 2023-12-29
BR112023021587A2 (pt) 2023-12-19
CO2023015286A2 (es) 2024-02-05
CA3216894A1 (en) 2022-10-27
PH12023552762A1 (en) 2024-04-15
TW202306982A (zh) 2023-02-16
AU2022263281A1 (en) 2023-11-09
AU2022263281A9 (en) 2023-11-16
CR20230533A (es) 2024-04-05
EP4326767A1 (en) 2024-02-28

Similar Documents

Publication Publication Date Title
AR125379A1 (es) Un fab anti-tslp con estabilidad mejorada
AR039003A1 (es) Composiciones y metodos para alterar el contenido de tocotrienoles
MX2022008197A (es) Metodo para el tratamiento del sindrome de usher y composicion del mismo.
AR111207A1 (es) Anticuerpos anti-lag3
AR086272A2 (es) Anticuerpos anti-factor d humanizados y sus usos
BR112017008108A2 (pt) incorporação de aminoácidos não naturais em proteínas
MX2018005063A (es) Polipéptidos condicionalmente activos.
AR110093A1 (es) D-psicosa 3-epimerasa y método para preparar d-psicosa utilizando la misma
AR070693A1 (es) Plantas que tienen rasgos aumentados relacionados con el rendimiento y un metodo para obtenerlas a partir de la expresion del polipeptido de nitrato 2 (nrt2)
AR114960A1 (es) Proteína tolerante a herbicida, gen codificante y uso de la misma
AR081740A1 (es) Plantas que tienen modificados rasgos relacionados con el rendimiento y un metodo para producirlas
BR112014022467A2 (pt) transformantes de rasamsonia
AR122047A2 (es) Polipéptido recombinante aislado con actividad pesticida, composición pesticida, molécula de ácido nucleico, célula huésped, construcción de adn, vector, método para producir dicho polipéptido y método para producir una planta transgénica
CO2017011431A2 (es) Proteínas de fusión de receptor de factor de crecimiento epidermal variante iii - mesotelina
AR084107A1 (es) Plantas con mejoras en la utilizacion de nitrogeno y tolerancia al estres
AR087719A2 (es) Celula de planta transformada, cultivo de tejidos y planta transgenica
ES2483916T3 (es) RHD6 y su uso en la modulación del desarrollo del pelo radicular en plantas
MX2022008298A (es) Anticuerpo para sesgar proporciones de sexos y metodos de uso del mismo.
AR127562A1 (es) ANTICUERPOS CONTRA EL FACTOR DE NECROSIS TUMORAL a HUMANO
AR050085A1 (es) Procedimiento para la generacion de plantas transgenicas con resistencia aumentada a patogenos por modificacion del contenido y/o la actividad de factores despolimerizantes de actina.
AR092210A1 (es) Trigo con alelos de rht-b1
AR123451A1 (es) Nueva proteína de exportación de o-fosfoserina y procedimiento para producir o-fosfoserina, cisteína, y sus derivados usando la misma
AR099811A1 (es) Microorganismos con una productividad de aminoácidos l mejorada y proceso para producir aminoácidos l
WO2020210480A3 (en) Factor h vectors and uses thereof
AR127131A1 (es) Cepa para producir ácido l-glutámico de alta concentración y método para producir ácido l-glutámico utilizando el mismo