AR124868A1 - Compuestos de heterociclo tetracíclicos útiles como inhibidores de la integrasa del vih - Google Patents
Compuestos de heterociclo tetracíclicos útiles como inhibidores de la integrasa del vihInfo
- Publication number
- AR124868A1 AR124868A1 ARP220100289A ARP220100289A AR124868A1 AR 124868 A1 AR124868 A1 AR 124868A1 AR P220100289 A ARP220100289 A AR P220100289A AR P220100289 A ARP220100289 A AR P220100289A AR 124868 A1 AR124868 A1 AR 124868A1
- Authority
- AR
- Argentina
- Prior art keywords
- tetracyclic heterocycle
- inhibitors
- heterocycle compounds
- compounds useful
- hiv integrase
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Tropical Medicine & Parasitology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- AIDS & HIV (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
Abstract
La presente invención se refiere a compuestos de heterociclo tetracíclicos de fórmula (1) y sus sales farmacéuticamente aceptables o profármacos de los mismos, en la que R¹ es como se define en el presente documento. La presente invención se refiere a composiciones que comprenden al menos un compuesto de heterociclo tetracíclico y a métodos de uso de los compuestos de heterociclo tetracíclicos para el tratamiento o la prevención de la infección por VIH en un sujeto.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163149927P | 2021-02-16 | 2021-02-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR124868A1 true AR124868A1 (es) | 2023-05-10 |
Family
ID=80625127
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP220100289A AR124868A1 (es) | 2021-02-16 | 2022-02-14 | Compuestos de heterociclo tetracíclicos útiles como inhibidores de la integrasa del vih |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US11958864B2 (es) |
| EP (1) | EP4294813B1 (es) |
| JP (1) | JP2024507788A (es) |
| KR (1) | KR20230147131A (es) |
| CN (1) | CN117083282A (es) |
| AR (1) | AR124868A1 (es) |
| AU (1) | AU2022223241A1 (es) |
| CA (1) | CA3208396A1 (es) |
| ES (1) | ES3048138T3 (es) |
| MX (1) | MX2023009445A (es) |
| TW (1) | TW202246286A (es) |
| WO (1) | WO2022177840A1 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN119462659A (zh) | 2019-03-22 | 2025-02-18 | 吉利德科学公司 | 桥连三环氨基甲酰基吡啶酮化合物及其药学用途 |
| AU2021225809B2 (en) | 2020-02-24 | 2023-08-24 | Gilead Sciences, Inc. | Tetracyclic compounds for treating HIV infection |
| JP7691494B2 (ja) | 2020-09-30 | 2025-06-11 | ギリアード サイエンシーズ， インコーポレイテッド | 架橋三環式カルバモイルピリドン化合物及びその使用 |
| HRP20231654T2 (hr) | 2021-01-19 | 2025-01-03 | Gilead Sciences, Inc. | Supstituirani spojevi piridotriazina i njihove uporabe |
| TWI856796B (zh) | 2022-04-06 | 2024-09-21 | 美商基利科學股份有限公司 | 橋聯三環胺甲醯基吡啶酮化合物及其用途 |
| WO2024226485A1 (en) * | 2023-04-28 | 2024-10-31 | Merck Sharp & Dohme Llc | Delivery devices for anti-hiv compounds |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101772610B1 (ko) * | 2008-07-25 | 2017-09-12 | 비이브 헬쓰케어 컴퍼니 | 화합물 |
| PL2320908T3 (pl) * | 2008-07-25 | 2014-06-30 | Viiv Healthcare Co | Proleki dolutegrawiru |
| EP2465858B1 (en) * | 2008-07-25 | 2013-12-25 | VIIV Healthcare Company | Process for preparing a pyrido[1,2-a]pyrrolo[1',2':3,4]imidazo[1,2-d]pyrazine-8-carboxamide derivative |
| SI2620436T1 (en) * | 2010-09-24 | 2018-08-31 | Shionogi & Co., Ltd. | Substituted polycyclic carbamoyl pyridone derivative prodrug |
| WO2017113288A1 (en) * | 2015-12-31 | 2017-07-06 | Merck Sharp & Dohme Corp. | Fused tricyclic heterocyclic compounds as hiv integrase inhibitors |
| JOP20190130A1 (ar) * | 2016-12-02 | 2019-06-02 | Merck Sharp & Dohme | مركبات حلقية غير متجانسة رباعية الحلقات مفيدة كمثبطات إنزيم مدمج لفيروس نقص المناعة البشرية (hiv) |
| EP3573984A4 (en) * | 2017-01-26 | 2020-07-29 | Merck Sharp & Dohme Corp. | USEFUL SUBSTITUTE QUINOLIZINE DERIVATIVES AS HIV INTEGRASE INHIBITORS |
-
2022
- 2022-02-14 US US17/670,689 patent/US11958864B2/en active Active
- 2022-02-14 AU AU2022223241A patent/AU2022223241A1/en active Pending
- 2022-02-14 WO PCT/US2022/016261 patent/WO2022177840A1/en not_active Ceased
- 2022-02-14 ES ES22707560T patent/ES3048138T3/es active Active
- 2022-02-14 TW TW111105302A patent/TW202246286A/zh unknown
- 2022-02-14 CA CA3208396A patent/CA3208396A1/en active Pending
- 2022-02-14 CN CN202280022034.3A patent/CN117083282A/zh active Pending
- 2022-02-14 JP JP2023548941A patent/JP2024507788A/ja active Pending
- 2022-02-14 AR ARP220100289A patent/AR124868A1/es unknown
- 2022-02-14 MX MX2023009445A patent/MX2023009445A/es unknown
- 2022-02-14 EP EP22707560.3A patent/EP4294813B1/en active Active
- 2022-02-14 KR KR1020237031339A patent/KR20230147131A/ko active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU2022223241A1 (en) | 2023-08-24 |
| JP2024507788A (ja) | 2024-02-21 |
| CA3208396A1 (en) | 2022-08-25 |
| CN117083282A (zh) | 2023-11-17 |
| EP4294813B1 (en) | 2025-09-10 |
| ES3048138T3 (en) | 2025-12-09 |
| WO2022177840A1 (en) | 2022-08-25 |
| MX2023009445A (es) | 2023-08-25 |
| EP4294813A1 (en) | 2023-12-27 |
| KR20230147131A (ko) | 2023-10-20 |
| US11958864B2 (en) | 2024-04-16 |
| US20220259227A1 (en) | 2022-08-18 |
| TW202246286A (zh) | 2022-12-01 |
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