AR112683A1 - Forma cristalina de base libre de levodopa, su sal de adición y composición farmaceutica que la comprende - Google Patents
Forma cristalina de base libre de levodopa, su sal de adición y composición farmaceutica que la comprendeInfo
- Publication number
- AR112683A1 AR112683A1 ARP180102329A AR112683A1 AR 112683 A1 AR112683 A1 AR 112683A1 AR P180102329 A ARP180102329 A AR P180102329A AR 112683 A1 AR112683 A1 AR 112683A1
- Authority
- AR
- Argentina
- Prior art keywords
- levodopa
- around
- pharmaceutical composition
- addition salt
- crystal form
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Una base libre de amida de levodopa cristalina y un proceso para elaborarla. En particular, una base libre de amida de levodopa cristalina sustancialmente pura, adecuada para la preparación de composiciones farmacéuticas para el tratamiento de enfermedades o trastornos caracterizados por la neurodegeneración y/o niveles reducidos de dopamina cerebral, tales como la enfermedad de Parkinson. Reivindicación 1: Una forma cristalina de base libre de L-dopamida, en donde la forma cristalina se caracteriza por un patrón de difracción de rayos X de polvo que tiene picos característicos en grados 2q a alrededor de 19,7 y alrededor de 21,0. Reivindicación 2: La forma cristalina de acuerdo con la reivindicación 1 también puede tener picos característicos en grados 2q a alrededor de 18,1 y alrededor de 28,9.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762548111P | 2017-08-21 | 2017-08-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR112683A1 true AR112683A1 (es) | 2019-11-27 |
Family
ID=63683238
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP180102329 AR112683A1 (es) | 2017-08-21 | 2018-08-15 | Forma cristalina de base libre de levodopa, su sal de adición y composición farmaceutica que la comprende |
Country Status (2)
| Country | Link |
|---|---|
| AR (1) | AR112683A1 (es) |
| WO (1) | WO2019038639A1 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20201948T1 (hr) | 2014-03-13 | 2021-01-22 | Neuroderm Ltd | Pripravci inhibitora dopa-dekarbokilaze |
| US10258585B2 (en) | 2014-03-13 | 2019-04-16 | Neuroderm, Ltd. | DOPA decarboxylase inhibitor compositions |
| US11331293B1 (en) | 2020-11-17 | 2022-05-17 | Neuroderm, Ltd. | Method for treatment of Parkinson's disease |
| US11213502B1 (en) | 2020-11-17 | 2022-01-04 | Neuroderm, Ltd. | Method for treatment of parkinson's disease |
| US11844754B2 (en) | 2020-11-17 | 2023-12-19 | Neuroderm, Ltd. | Methods for treatment of Parkinson's disease |
| US12161612B2 (en) | 2023-04-14 | 2024-12-10 | Neuroderm, Ltd. | Methods and compositions for reducing symptoms of Parkinson's disease |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004069146A2 (en) | 2003-02-07 | 2004-08-19 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | L-dopa amide derivatives and uses thereof |
| EP3380076A2 (en) | 2015-11-24 | 2018-10-03 | Neuroderm, Ltd. | Pharmaceutical compositions comprising levodopa amide and uses thereof |
-
2018
- 2018-08-15 WO PCT/IB2018/056127 patent/WO2019038639A1/en not_active Ceased
- 2018-08-15 AR ARP180102329 patent/AR112683A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2019038639A1 (en) | 2019-02-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |