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AR112440A1 - CRYSTAL FORM OF A BCL-2 INHIBITOR, A PROCESS FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING IT - Google Patents

CRYSTAL FORM OF A BCL-2 INHIBITOR, A PROCESS FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING IT

Info

Publication number
AR112440A1
AR112440A1 ARP180101871A AR112440A1 AR 112440 A1 AR112440 A1 AR 112440A1 AR P180101871 A ARP180101871 A AR P180101871A AR 112440 A1 AR112440 A1 AR 112440A1
Authority
AR
Argentina
Prior art keywords
bcl
inhibitor
preparation
pharmaceutical compositions
compositions containing
Prior art date
Application number
Other languages
Spanish (es)
Inventor
Blanc Alan Le
Sylvie Dhulut
Julie Linol
Michael Lynch
Original Assignee
Servier Lab
Vernalis R&D Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab, Vernalis R&D Ltd filed Critical Servier Lab
Publication of AR112440A1 publication Critical patent/AR112440A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Reivindicación 1: Forma cristalina II del hidrocloruro de N-(4-hidroxifenil)-3-{6-[((3S)-3-(4-morfolinilmetil)-3,4-dihidro-2(1H)-isoquinolinil)carbonil]-1,3-benzodioxol-5-il}-N-fenil-5,6,7,8-tetrahidro-1-indolizina carboxamida (Compuesto A. HCl) que muestra al menos las siguientes líneas de difracción (ángulo 2q de Bragg, expresado en grados ± 0,2º): 15,23 y 15,47. Reivindicación 2: Forma cristalina II del hidrocloruro de N-(4-hidroxifenil)-3-{6-[((3S)-3-(4-morfolinilmetil)-3,4-dihidro-2(1H)-isoquinolinil)carbonil]-1,3-benzodioxol-5-il}-N-fenil-5,6,7,8-tetrahidro-1-indolizina carboxamida (Compuesto A. HCl), caracterizada porque tiene un diagrama de difracción de rayos X de polvo que muestra al menos 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14 o todas las siguientes líneas de difracción (ángulo 2q de Bragg, expresado en grados ± 0,2º): 4,09; 8,19; 9,15; 10,82; 12,83; 15,23; 15,47; 16,40; 19,17; 19,87; 20,39; 20,88; 21,76; 23,19; 24,06.Claim 1: Crystalline form II of N- (4-hydroxyphenyl) -3- {6 - [((3S) -3- (4-morpholinylmethyl) -3,4-dihydro-2 (1H) -isoquinolinyl) carbonyl hydrochloride ] -1,3-benzodioxol-5-yl} -N-phenyl-5,6,7,8-tetrahydro-1-indolizine carboxamide (Compound A. HCl) showing at least the following diffraction lines (angle 2q of Bragg, expressed in degrees ± 0.2º): 15.23 and 15.47. Claim 2: Crystalline form II of N- (4-hydroxyphenyl) -3- {6 - [((3S) -3- (4-morpholinylmethyl) -3,4-dihydro-2 (1H) -isoquinolinyl) carbonyl hydrochloride ] -1,3-benzodioxol-5-yl} -N-phenyl-5,6,7,8-tetrahydro-1-indolizine carboxamide (Compound A. HCl), characterized in that it has a powder X-ray diffraction pattern showing at least 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14 or all of the following diffraction lines (Bragg angle 2q, expressed in degrees ± 0.2º): 4.09 ; 8.19; 9.15; 10.82; 12.83; 15.23; 15.47; 16.40; 19.17; 19.87; 20.39; 20.88; 21.76; 23.19; 24.06.

ARP180101871 2017-07-06 2018-07-05 CRYSTAL FORM OF A BCL-2 INHIBITOR, A PROCESS FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING IT AR112440A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP17305876 2017-07-06

Publications (1)

Publication Number Publication Date
AR112440A1 true AR112440A1 (en) 2019-10-30

Family

ID=59350835

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP180101871 AR112440A1 (en) 2017-07-06 2018-07-05 CRYSTAL FORM OF A BCL-2 INHIBITOR, A PROCESS FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING IT

Country Status (3)

Country Link
AR (1) AR112440A1 (en)
TW (1) TWI672302B (en)
WO (1) WO2019008126A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11311347B2 (en) 2016-11-11 2022-04-26 Intuitive Surgical Operations, Inc. Teleoperated surgical system with surgical instrument wear tracking
WO2019134970A1 (en) * 2018-01-05 2019-07-11 Les Laboratoires Servier Novel salts of a bcl-2 inhibitor,related crystalline forms,method for preparing the same and pharmaceutical compositions containing the same

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2986002B1 (en) 2012-01-24 2014-02-21 Servier Lab NOVEL INDOLIZINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
FR3008979B1 (en) * 2013-07-23 2015-07-24 Servier Lab NOVEL PHOSPHATE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Also Published As

Publication number Publication date
TWI672302B (en) 2019-09-21
TW201906839A (en) 2019-02-16
WO2019008126A1 (en) 2019-01-10

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