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Publication of AR111637A1publicationCriticalpatent/AR111637A1/en
Medicines That Contain Protein Lipid Enzymes And Other Medicines
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Pharmaceuticals Containing Other Organic And Inorganic Compounds
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Abstract
La presente proporciona determinados ácidos nucleicos (por ejemplo, moléculas de ARNip de cadena doble), así como conjugados que comprenden un resto de direccionamiento, un ARNip de cadena doble, y grupos de enlace opcionales. Determinadas modalidades también proporcionan métodos de síntesis útiles para preparar los conjugados. Los conjugados son útiles para dirigir el ARNip de cadena doble terapéutico al hígado y para tratar enfermedades hepáticas, inclusive la hepatitis (por ejemplo, hepatitis B y hepatitis D). Composición farmacéutica; compuesto.This provides certain nucleic acids (eg, double stranded siRNA molecules), as well as conjugates comprising an targeting moiety, a double stranded siRNA, and optional binding groups. Certain modalities also provide useful synthesis methods for preparing the conjugates. The conjugates are useful for directing the therapeutic double stranded siRNA to the liver and for treating liver diseases, including hepatitis (for example, hepatitis B and hepatitis D). Pharmaceutical composition; compound.
binder-drug intermediate, antibody-drug conjugate compounds, pharmaceutical compositions, methods for treating cancer, method of producing an antibody-drug conjugate and conjugate