AR111462A1 - Enzimas lactasa con actividad mejorada a bajas temperaturas - Google Patents
Enzimas lactasa con actividad mejorada a bajas temperaturasInfo
- Publication number
- AR111462A1 AR111462A1 ARP180100909A ARP180100909A AR111462A1 AR 111462 A1 AR111462 A1 AR 111462A1 AR P180100909 A ARP180100909 A AR P180100909A AR P180100909 A ARP180100909 A AR P180100909A AR 111462 A1 AR111462 A1 AR 111462A1
- Authority
- AR
- Argentina
- Prior art keywords
- peptide
- concentration
- amino acid
- lactose
- mixture
- Prior art date
Links
- 230000000694 effects Effects 0.000 title abstract 5
- 108010059881 Lactase Proteins 0.000 title 1
- 108010005774 beta-Galactosidase Proteins 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 13
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 abstract 7
- 239000008101 lactose Substances 0.000 abstract 7
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 5
- 239000000203 mixture Substances 0.000 abstract 5
- 235000013365 dairy product Nutrition 0.000 abstract 3
- 239000000758 substrate Substances 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- 239000008267 milk Substances 0.000 abstract 2
- 235000013336 milk Nutrition 0.000 abstract 2
- 210000004080 milk Anatomy 0.000 abstract 2
- 102000002464 Galactosidases Human genes 0.000 abstract 1
- 108010093031 Galactosidases Proteins 0.000 abstract 1
- 230000006229 amino acid addition Effects 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 238000012217 deletion Methods 0.000 abstract 1
- 230000037430 deletion Effects 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/06—Enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2468—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1) acting on beta-galactose-glycoside bonds, e.g. carrageenases (3.2.1.83; 3.2.1.157); beta-agarase (3.2.1.81)
- C12N9/2471—Beta-galactosidase (3.2.1.23), i.e. exo-(1-->4)-beta-D-galactanase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01023—Beta-galactosidase (3.2.1.23), i.e. exo-(1-->4)-beta-D-galactanase
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Enzymes And Modification Thereof (AREA)
- Dairy Products (AREA)
Abstract
Reivindicación 1: Un método para producir un producto lácteo que comprende lo siguiente: (a) mezclar un sustrato con base láctea que comprende lactosa en una concentración de al menos 10 g/L y un péptido o un péptido dimérico que muestra actividad de b-galactosidasa en una concentración que fluctúa entre 10 y 55 mg/L; (b) incubar la mezcla a una temperatura que oscila entre 1ºC y 10ºC durante un lapso suficiente para reducir la concentración de lactosa en la mezcla hasta menos de 0,2 g/L. Reivindicación 2: Un método para reducir el contenido de lactosa en un sustrato con base láctea que comprende lo siguiente: (a) mezclar un sustrato con base láctea que comprenden lactosa en una concentración de al menos 10 g/L y un péptido o un péptido dimérico que muestra actividad de b-galactosidasa en una concentración que fluctúa entre 10 y 55 mg/L; (b) incubar la mezcla a una temperatura que oscila entre 1ºC y 10ºC durante un lapso suficiente para reducir la concentración de lactosa en la mezcla hasta menos de 0,2 g/L. Reivindicación 15: Uso de un péptido o péptido dimérico que muestra actividad de b-galactosidasa para producir un producto lácteo con contenido de lactosa reducido a una temperatura que oscila entre 1ºC y 10ºC durante un lapso suficiente para reducir la concentración de lactosa en la mezcla hasta menos de 0,2 g/L, en el cual el péptido o péptido dimérico que muestra actividad de b-galactosidasa es como se detalla a continuación: (i) un péptido que tiene una secuencia de aminoácido seleccionada entre la SEQ ID Nº 22, 33, 14, 7, 9, 11, 30 y 1 o un péptido que tiene una identidad de secuencia de aminoácido de más del 85% con respecto a cualquiera de estas secuencias; (ii) un péptido que tiene una secuencia de aminoácido seleccionada entre la SEQ ID Nº 22, 33, 14, 13, 19, 7, 9, 11, 26 y 27, 30 y 1 o un péptido que tiene una identidad de secuencia de aminoácido de más del 85% con respecto a cualquiera de estas secuencias; (iii) un péptido que tiene una secuencia de aminoácido representada por la SEQ ID Nº 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, o fragmentos enzimáticamente activos de ellas, o una secuencia de aminoácido de una cualquiera de ellas que no tienen más de 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, ó 22 eliminaciones, adiciones o sustituciones de aminoácido.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17166021 | 2017-04-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR111462A1 true AR111462A1 (es) | 2019-07-17 |
Family
ID=58548558
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP180100908A AR111373A1 (es) | 2017-04-11 | 2018-04-11 | Enzimas de lactasa con propiedades mejoradas |
| ARP180100909A AR111462A1 (es) | 2017-04-11 | 2018-04-11 | Enzimas lactasa con actividad mejorada a bajas temperaturas |
| ARP180100907A AR111589A1 (es) | 2017-04-11 | 2018-04-11 | Enzimas lactasas con propiedades mejoradas |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP180100908A AR111373A1 (es) | 2017-04-11 | 2018-04-11 | Enzimas de lactasa con propiedades mejoradas |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP180100907A AR111589A1 (es) | 2017-04-11 | 2018-04-11 | Enzimas lactasas con propiedades mejoradas |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US11525129B2 (es) |
| EP (3) | EP4011906A3 (es) |
| CN (1) | CN110678479A (es) |
| AR (3) | AR111373A1 (es) |
| AU (3) | AU2018251957C9 (es) |
| BR (1) | BR112019021142A2 (es) |
| CA (1) | CA3059275A1 (es) |
| MA (1) | MA50221A (es) |
| NZ (1) | NZ757945A (es) |
| PT (1) | PT3609908T (es) |
| WO (1) | WO2018189224A1 (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MA50220A (fr) | 2017-04-11 | 2020-07-22 | Chr Hansen As | Enzymes de lactase ayant une activité améliorée à basses températures |
| NZ757950A (en) | 2017-04-11 | 2025-09-26 | Kerry Group Services Int Ltd | Lactase enzymes with improved properties |
| US12435326B2 (en) | 2017-04-11 | 2025-10-07 | Kerry Group Services International Ltd | Lactase enzymes with improved properties |
| EP3930469A4 (en) * | 2019-02-28 | 2023-03-01 | DuPont Nutrition Biosciences ApS | PROCESS FOR REDUCING LACTOSE AT HIGH TEMPERATURES |
| WO2021037986A1 (en) * | 2019-08-30 | 2021-03-04 | Chr. Hansen A/S | Production of lactase enzymes using altered regulation strains |
| WO2021170559A1 (en) * | 2020-02-26 | 2021-09-02 | Novozymes A/S | Polypeptide variants |
| CN112979749A (zh) * | 2021-02-26 | 2021-06-18 | 深圳海创生物科技有限公司 | 一种活性环肽、活性环肽组合物及其在制备具有抗氧化作用或抗衰老作用的产品中的应用 |
| US20250331529A1 (en) * | 2021-12-22 | 2025-10-30 | Novozymes A/S | Method of Producing a Milk-Based Product |
| CN114806906B (zh) * | 2022-05-31 | 2023-02-21 | 江南大学 | 一株产中性乳糖酶的乳酸克鲁维酵母 |
| CN119730728A (zh) | 2022-06-07 | 2025-03-28 | 凯里集团国际有限公司 | 通过添加选自苹果酸根、酒石酸根、柠檬酸根、葡萄糖酸根、edta或其组合的阴离子来改善乳糖酶的过滤性和所获得的无菌过滤乳糖酶产品 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003504048A (ja) | 1999-07-09 | 2003-02-04 | ユニベルシテ ドゥ リエージュ | 低温活性ベータ・ガラクトシダーゼ、その製法、及びその使用 |
| EP1227152A1 (en) | 2001-01-30 | 2002-07-31 | Société des Produits Nestlé S.A. | Bacterial strain and genome of bifidobacterium |
| US7459289B2 (en) | 2004-03-08 | 2008-12-02 | North Carolina State University | Lactobacillus acidophilus nucleic acid sequences encoding carbohydrate utilization-related proteins and uses therefor |
| US7608700B2 (en) | 2004-03-08 | 2009-10-27 | North Carolina State University | Lactobacillus acidophilus nucleic acid sequences encoding stress-related proteins and uses therefor |
| RU2278160C2 (ru) | 2004-04-13 | 2006-06-20 | Институт Молекулярной Генетики Российской Академии Наук (Имг Ран) | РЕКОМБИНАНТНЫЙ БЕЛОК LACspCBD, ОБЛАДАЮЩИЙ БЕТА-ГАЛАКТОЗИДАЗНОЙ АКТИВНОСТЬЮ И СПОСОБНОСТЬЮ САМОПРОИЗВОЛЬНО СВЯЗЫВАТЬСЯ С ЦЕЛЛЮЛОЗОСОДЕРЖАЩИМИ СОРБЕНТАМИ, РЕКОМБИНАНТНАЯ ПЛАЗМИДНАЯ ДНК, КОДИРУЮЩАЯ СИНТЕЗ РЕКОМБИНАНТНОГО БЕЛКА LACspCBD, ШТАММ Escherichia coli M15 [pREP4, pLACspCBD] - ПРОДУЦЕНТ РЕКОМБИНАНТНОГО БЕЛКА LACspCBD, СПОСОБ ПОЛУЧЕНИЯ ИММОБИЛИЗОВАННОГО РЕКОМБИНАНТНОГО БЕЛКА LACspCBD НА ЦЕЛЛЮЛОЗЕ И СПОСОБ ФЕРМЕНТАТИВНОГО РАСЩЕПЛЕНИЯ ЛАКТОЗЫ |
| GB0601901D0 (en) * | 2006-01-31 | 2006-03-08 | Product and Process | |
| GB0606112D0 (en) | 2006-03-28 | 2006-05-03 | Product and process | |
| WO2008033520A2 (en) | 2006-09-15 | 2008-03-20 | The Regents Of The University Of California | Bifidobacterial gene sequences and their use |
| US20110265221A1 (en) * | 2007-07-10 | 2011-10-27 | Monsanto Technology Llc | Transgenic plants with enhanced agronomic traits |
| PL2234501T3 (pl) | 2007-12-03 | 2017-08-31 | Novozymes A/S | Sposób otrzymywania produktu mlecznego o niskiej zawartości laktozy |
| US20090297660A1 (en) | 2008-06-02 | 2009-12-03 | Kraft Food Holdings, Inc. | Cheese Products Containing Galacto-Oligosaccharides And Having Reduced Lactose Levels |
| EP2396403B8 (en) * | 2009-02-10 | 2015-11-18 | Coldzymes ApS | Cold-active beta-galactosidase, a method of producing same and use of such enzyme |
| CN101899463B (zh) * | 2010-07-05 | 2012-05-02 | 山东大学 | 一种带有纤维素吸附域的β-半乳糖苷酶及其应用 |
| EP2530148B1 (en) * | 2011-05-30 | 2015-04-29 | B.R.A.I.N. Biotechnology Research And Information Network AG | Novel beta-galactosidases useful for the production of lactose depleted milk products |
| AR090851A1 (es) | 2012-04-25 | 2014-12-10 | Chr Hansen As | Uso de bacteria acida lactica para preparar productos alimenticios fermentados con una dulzura natural incrementada |
| CN103275953B (zh) * | 2013-06-25 | 2014-06-18 | 山东大学 | 一种转苷底物特异性拓宽的β-半乳糖苷酶 |
| CN103431042B (zh) | 2013-08-28 | 2015-01-21 | 光明乳业股份有限公司 | 发酵乳基料、脱乳清风味发酵乳、原料组合物及制备方法 |
| JP6632526B2 (ja) | 2014-01-14 | 2020-01-22 | ディーエスエム アイピー アセッツ ビー．ブイ．Ｄｓｍ Ｉｐ Ａｓｓｅｔｓ Ｂ．Ｖ． | クルイベロミセス・ラクティス（ｋｌｕｙｖｅｒｏｍｙｃｅｓ ｌａｃｔｉｓ）由来のラクターゼの改良型酵素変異体 |
| EP2957180B1 (en) | 2014-06-19 | 2018-03-14 | Chr. Hansen A/S | Method of producing a fermented milk product with improved control of post acidification |
| EP3208332B1 (en) | 2014-10-17 | 2020-03-04 | Godo Shusei Co., Ltd. | Lactase solution and milk using same |
| WO2017106264A1 (en) * | 2015-12-14 | 2017-06-22 | Dupont Nutrition Biosciences Aps | Method for producing a clean lactase |
| BR112018074946A2 (pt) | 2016-06-14 | 2019-03-06 | Chr Hansen As | produto lácteo fermentado com um teor reduzido de lactose |
| WO2018041869A1 (en) | 2016-08-31 | 2018-03-08 | Chr. Hansen A/S | Process for producing a heat-treated fermented milk product |
| US20190343138A1 (en) | 2017-01-13 | 2019-11-14 | Chr. Hansen A/S | Process for producing a fermented milk product |
| KR102533803B1 (ko) * | 2017-04-07 | 2023-05-18 | 듀폰 뉴트리션 바이오사이언시즈 에이피에스 | p-니트로벤질에스터라제 부활성의 부재 하에 β-갈락토시다제 및 락타제를 생산하는 바실러스 숙주 세포 |
| US12435326B2 (en) | 2017-04-11 | 2025-10-07 | Kerry Group Services International Ltd | Lactase enzymes with improved properties |
| NZ757950A (en) | 2017-04-11 | 2025-09-26 | Kerry Group Services Int Ltd | Lactase enzymes with improved properties |
| MA50220A (fr) | 2017-04-11 | 2020-07-22 | Chr Hansen As | Enzymes de lactase ayant une activité améliorée à basses températures |
| EP4407027A3 (en) | 2018-10-17 | 2024-11-13 | Chr. Hansen A/S | Lactase enzymes with improved properties at acidic ph |
-
2018
- 2018-04-11 US US16/604,129 patent/US11525129B2/en active Active
- 2018-04-11 AU AU2018251957A patent/AU2018251957C9/en active Active
- 2018-04-11 CA CA3059275A patent/CA3059275A1/en active Pending
- 2018-04-11 AR ARP180100908A patent/AR111373A1/es unknown
- 2018-04-11 EP EP21211668.5A patent/EP4011906A3/en active Pending
- 2018-04-11 EP EP18716624.4A patent/EP3609910B1/en active Active
- 2018-04-11 BR BR112019021142-0A patent/BR112019021142A2/pt unknown
- 2018-04-11 WO PCT/EP2018/059250 patent/WO2018189224A1/en not_active Ceased
- 2018-04-11 EP EP25218795.0A patent/EP4678743A2/en active Pending
- 2018-04-11 AR ARP180100909A patent/AR111462A1/es unknown
- 2018-04-11 AR ARP180100907A patent/AR111589A1/es unknown
- 2018-04-11 MA MA050221A patent/MA50221A/fr unknown
- 2018-04-11 NZ NZ757945A patent/NZ757945A/en unknown
- 2018-04-11 PT PT187157433T patent/PT3609908T/pt unknown
- 2018-04-11 CN CN201880035256.2A patent/CN110678479A/zh active Pending
-
2022
- 2022-03-25 AU AU2022202060A patent/AU2022202060A1/en not_active Abandoned
- 2022-11-14 US US17/986,618 patent/US12215367B2/en active Active
-
2024
- 2024-04-12 AU AU2024202396A patent/AU2024202396A1/en active Pending
-
2025
- 2025-01-17 US US19/029,745 patent/US20250163397A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU2018251957C9 (en) | 2025-03-20 |
| AR111589A1 (es) | 2019-07-31 |
| EP4011906A3 (en) | 2022-09-07 |
| AU2018251957C1 (en) | 2023-09-28 |
| EP4011906A2 (en) | 2022-06-15 |
| NZ757945A (en) | 2025-10-31 |
| MA50221A (fr) | 2020-07-22 |
| US20250163397A1 (en) | 2025-05-22 |
| US20230235307A1 (en) | 2023-07-27 |
| PT3609908T (pt) | 2025-11-11 |
| EP3609910A1 (en) | 2020-02-19 |
| AU2024202396A1 (en) | 2024-05-02 |
| CN110678479A (zh) | 2020-01-10 |
| AU2022202060A1 (en) | 2022-04-14 |
| EP3609910B1 (en) | 2025-12-31 |
| US20210355471A1 (en) | 2021-11-18 |
| EP4678743A2 (en) | 2026-01-14 |
| BR112019021142A2 (pt) | 2020-05-12 |
| US12215367B2 (en) | 2025-02-04 |
| RU2019134240A (ru) | 2021-05-11 |
| CA3059275A1 (en) | 2018-10-18 |
| AR111373A1 (es) | 2019-07-03 |
| AU2018251957B2 (en) | 2022-04-07 |
| WO2018189224A1 (en) | 2018-10-18 |
| AU2018251957A1 (en) | 2019-10-31 |
| US11525129B2 (en) | 2022-12-13 |
| RU2019134240A3 (es) | 2021-10-22 |
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