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AR111093A1 - PROCESS FOR THE PREPARATION OF 2-CHLORINE-4-FLUORO-5-NITROBENZOTRICLORIDE - Google Patents

PROCESS FOR THE PREPARATION OF 2-CHLORINE-4-FLUORO-5-NITROBENZOTRICLORIDE

Info

Publication number
AR111093A1
AR111093A1 ARP180100267A ARP180100267A AR111093A1 AR 111093 A1 AR111093 A1 AR 111093A1 AR P180100267 A ARP180100267 A AR P180100267A AR P180100267 A ARP180100267 A AR P180100267A AR 111093 A1 AR111093 A1 AR 111093A1
Authority
AR
Argentina
Prior art keywords
range
temperature
nitrobenzotricloride
fluoro
mixture
Prior art date
Application number
ARP180100267A
Other languages
Spanish (es)
Original Assignee
Basf Agro Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Agro Bv filed Critical Basf Agro Bv
Publication of AR111093A1 publication Critical patent/AR111093A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/06—Preparation of nitro compounds
    • C07C201/08—Preparation of nitro compounds by substitution of hydrogen atoms by nitro groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/07—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms
    • C07C205/11—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to carbon atoms of six-membered aromatic rings
    • C07C205/12—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to carbon atoms of six-membered aromatic rings the six-membered aromatic ring or a condensed ring system containing that ring being substituted by halogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Reivindicación 1: Un proceso para la preparación de 2-cloro-4-fluoro-5-nitrobenzotricloruro caracterizado porque comprende los pasos de A) la reacción de 2-cloro-4-fluorobenzotricloruro con una mezcla sulfonítrica a una temperatura en el intervalo de ³ 0ºC a £ 15ºC para obtener una mezcla de reacción; B) la adición de un solvente orgánico halogenado a la mezcla de reacción del paso (A) a una temperatura en el intervalo de ³ 0ºC a £ 15ºC para obtener una capa orgánica una capa ácida; C) la separación de la capa orgánica y la capa ácida del paso (B); D) el lavado de la capa orgánica del paso (C) con una solución acuosa de una base inorgánica a una temperatura en el intervalo de ³ 10ºC a £ 15ºC; E) la concentración de la capa orgánica del paso (D) para obtener un producto en bruto; F) la mezcla del producto en bruto del paso (E) con por lo menos un solvente orgánico y agua y el calentamiento a una temperatura en el intervalo de ³ 60ºC a £ 70ºC para obtener una mezcla en bruto; G) el almacenamiento de la mezcla en bruto a una temperatura en el intervalo de ³ 0ºC a £ 15ºC; H) la obtención de 2-cloro-4-fluoro-5-nitrobenzotricloruro de la mezcla en bruto.Claim 1: A process for the preparation of 2-chloro-4-fluoro-5-nitrobenzotricloride characterized in that it comprises the steps of A) the reaction of 2-chloro-4-fluorobenzotricloride with a sulfonitric mixture at a temperature in the range of ³ 0 ° C to £ 15 ° C to obtain a reaction mixture; B) the addition of a halogenated organic solvent to the reaction mixture of step (A) at a temperature in the range of ³ 0 ° C to £ 15 ° C to obtain an organic layer an acidic layer; C) the separation of the organic layer and the acid layer from step (B); D) washing the organic layer of step (C) with an aqueous solution of an inorganic base at a temperature in the range of ³ 10 ° C to £ 15 ° C; E) the concentration of the organic layer of step (D) to obtain a crude product; F) mixing the crude product from step (E) with at least one organic solvent and water and heating at a temperature in the range of ³ 60 ° C to £ 70 ° C to obtain a crude mixture; G) storage of the crude mixture at a temperature in the range of ³ 0 ° C to £ 15 ° C; H) obtaining 2-chloro-4-fluoro-5-nitrobenzotricloride from the crude mixture.

ARP180100267A 2017-02-06 2018-02-05 PROCESS FOR THE PREPARATION OF 2-CHLORINE-4-FLUORO-5-NITROBENZOTRICLORIDE AR111093A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP17154825 2017-02-06

Publications (1)

Publication Number Publication Date
AR111093A1 true AR111093A1 (en) 2019-06-05

Family

ID=57965839

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP180100267A AR111093A1 (en) 2017-02-06 2018-02-05 PROCESS FOR THE PREPARATION OF 2-CHLORINE-4-FLUORO-5-NITROBENZOTRICLORIDE

Country Status (2)

Country Link
AR (1) AR111093A1 (en)
WO (1) WO2018141642A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018172109A1 (en) 2017-03-20 2018-09-27 Basf Se Process for preparing bromotrichloromethane
US11358922B2 (en) 2017-11-02 2022-06-14 Basf Se Process for preparing 4-chlorobenzyl propargyl ether
CN109232258A (en) * 2018-11-20 2019-01-18 宿州学院 A kind of fluoro- 5- nitrotrichloromethane benzene synthesis post-processing approach of the chloro- 4- of 2-
CN109265349A (en) * 2018-11-20 2019-01-25 宿州学院 A method of efficiently synthesizing the fluoro- 5- nitrotrichloromethane benzene of the chloro- 4- of 2-

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3217619A1 (en) 1982-05-11 1983-11-17 Bayer Ag, 5090 Leverkusen 2,4-DIHALOGENBENZOYL (THIO) UREA, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS A PEST CONTROL
RU2006131045A (en) * 2004-01-30 2008-03-10 Мерк Патент ГмбХ (DE) Derivatives of bisaryl urea
ITMI20050275A1 (en) 2005-02-22 2006-08-23 Miteni Spa PROCEDURE FOR THE PREPARATION OF BENZOIC ACID DERIVATIVES THROUGH A NEW INTERMEDIATE SYNTHESIS
CN106083595A (en) * 2016-06-08 2016-11-09 常州安迪沃克医药科技有限公司 The synthetic method of cancer therapy drug Ceritinib intermediate 2 chlorine (bromine) 4 fluorine 5 Methylnitrobenzene

Also Published As

Publication number Publication date
WO2018141642A1 (en) 2018-08-09

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