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AR110751A1 - Método para tratar o mejorar trastornos metabólicos mediante el uso de agonistas del receptor glp-1 conjugados con proteínas de unión al receptor del péptido inhibidor gástrico (gipr) - Google Patents

Método para tratar o mejorar trastornos metabólicos mediante el uso de agonistas del receptor glp-1 conjugados con proteínas de unión al receptor del péptido inhibidor gástrico (gipr)

Info

Publication number
AR110751A1
AR110751A1 ARP180100097A ARP180100097A AR110751A1 AR 110751 A1 AR110751 A1 AR 110751A1 AR P180100097 A ARP180100097 A AR P180100097A AR P180100097 A ARP180100097 A AR P180100097A AR 110751 A1 AR110751 A1 AR 110751A1
Authority
AR
Argentina
Prior art keywords
glp
amino acid
antibody
receptor
gipr
Prior art date
Application number
ARP180100097A
Other languages
English (en)
Inventor
Jing Xu
Junming Yie
Shanaka Stanislaus
Murielle Veniant-Ellison
Shu Lu
- Miranda Leslie Chen
Kelvin Sham
Bradley Herberich
James Falsey
Bin Wu
Jerry Holder
Yuan Cheng
Chawita Netirojjanakul
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=61832572&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR110751(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of AR110751A1 publication Critical patent/AR110751A1/es

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    • A—HUMAN NECESSITIES
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6847—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a hormone or a hormone-releasing or -inhibiting factor
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P13/00—Drugs for disorders of the urinary system
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    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2869—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
    • A—HUMAN NECESSITIES
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell

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Abstract

Se proveen métodos para tratar enfermedades y trastornos metabólicos usando una composición que comprende una proteína de unión al antígeno específica para el polipéptido GIPR conjugada a un agonista del receptor GLP-1. En varias modalidades la enfermedad o trastorno metabólico es la diabetes tipo 2, obesidad, dislipidemia, niveles elevados de glucosa, niveles elevados de insulina o nefropatía diabética. Reivindicación 1: Una composición que comprende a) un anticuerpo o fragmento funcional de este que se une específicamente a una proteína que tiene una secuencia de aminoácidos que tiene al menos 90% identidad de secuencia de aminoácidos con una secuencia de aminoácidos de una GIPR humana, donde el anticuerpo o fragmento funcional de este comprende una cisteína o sustitución de aminoácido no canónico en uno o más sitio(s) de conjugación que se seleccionan del grupo que consiste en D70 de la cadena ligera de anticuerpo con relación a la secuencia de referencia SEQ ID Nº 455, E276 de la cadena pesada de anticuerpo con relación a la secuencia de referencia SEQ ID Nº 612, y T363 de la cadena pesada de anticuerpo con relación a la secuencia de referencia SEQ ID Nº 612; y b) un agonista del receptor GLP-1, donde el agonista del receptor GLP-1 se conjuga con el anticuerpo o fragmento funcional de este a través de la cadena lateral del residuo de cisteína o residuo de aminoácido no canónico sustituido en uno o más sitio(s) de conjugación.
ARP180100097A 2017-01-17 2018-01-16 Método para tratar o mejorar trastornos metabólicos mediante el uso de agonistas del receptor glp-1 conjugados con proteínas de unión al receptor del péptido inhibidor gástrico (gipr) AR110751A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201762447332P 2017-01-17 2017-01-17

Publications (1)

Publication Number Publication Date
AR110751A1 true AR110751A1 (es) 2019-05-02

Family

ID=61832572

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Application Number Title Priority Date Filing Date
ARP180100097A AR110751A1 (es) 2017-01-17 2018-01-16 Método para tratar o mejorar trastornos metabólicos mediante el uso de agonistas del receptor glp-1 conjugados con proteínas de unión al receptor del péptido inhibidor gástrico (gipr)

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US (3) US10905772B2 (es)
EP (2) EP3570885B1 (es)
JP (3) JP7175899B2 (es)
KR (3) KR20250038835A (es)
CN (2) CN118079021A (es)
AR (1) AR110751A1 (es)
AU (2) AU2018210858B2 (es)
BR (1) BR112019014588A2 (es)
CA (1) CA3049023A1 (es)
CL (1) CL2019001963A1 (es)
CO (1) CO2019007685A2 (es)
CR (2) CR20230302A (es)
DK (1) DK3570885T3 (es)
EA (1) EA201991721A1 (es)
ES (1) ES3009462T3 (es)
FI (1) FI3570885T3 (es)
HR (1) HRP20241563T1 (es)
HU (1) HUE069334T2 (es)
IL (2) IL267660B2 (es)
JO (1) JOP20190177A1 (es)
LT (1) LT3570885T (es)
MA (1) MA47314B1 (es)
MD (1) MD3570885T2 (es)
MX (2) MX2019008462A (es)
NZ (1) NZ754937A (es)
PE (2) PE20191467A1 (es)
PH (1) PH12019501656A1 (es)
PL (1) PL3570885T3 (es)
PT (1) PT3570885T (es)
RS (1) RS66291B1 (es)
SA (1) SA519402246B1 (es)
SG (1) SG11201906525SA (es)
SI (1) SI3570885T1 (es)
SM (1) SMT202400502T1 (es)
TW (1) TWI708613B (es)
UY (1) UY37568A (es)
WO (1) WO2018136440A1 (es)
ZA (1) ZA201904287B (es)

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