AR110406A1 - 6-AMINO-5-FLUORO-5- (FLUOROMETIL) -2,3,4,5-TETRAHIDROPIRIDIN-2-IL-FENIL-5- (METOXI-D₃) -PIRAZINA-2-CARBOXAMIDS AND FLUORATED DERIVATIVES OF THE SAME AS BACE1 INHIBITORS - Google Patents
6-AMINO-5-FLUORO-5- (FLUOROMETIL) -2,3,4,5-TETRAHIDROPIRIDIN-2-IL-FENIL-5- (METOXI-D₃) -PIRAZINA-2-CARBOXAMIDS AND FLUORATED DERIVATIVES OF THE SAME AS BACE1 INHIBITORSInfo
- Publication number
- AR110406A1 AR110406A1 ARP170103599A ARP170103599A AR110406A1 AR 110406 A1 AR110406 A1 AR 110406A1 AR P170103599 A ARP170103599 A AR P170103599A AR P170103599 A ARP170103599 A AR P170103599A AR 110406 A1 AR110406 A1 AR 110406A1
- Authority
- AR
- Argentina
- Prior art keywords
- tetrahidropiridin
- fluorometil
- pirazina
- carboxamids
- metoxi
- Prior art date
Links
- 229940125759 BACE1 protease inhibitor Drugs 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 229910052736 halogen Chemical group 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical group FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- -1 amidine compounds Chemical class 0.000 abstract 1
- 208000010877 cognitive disease Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052805 deuterium Inorganic materials 0.000 abstract 1
- 229910052731 fluorine Chemical group 0.000 abstract 1
- 239000011737 fluorine Chemical group 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 230000000626 neurodegenerative effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente solicitud proporciona compuestos de amidina para el tratamiento de enfermedades neurodegenerativas o cognitivas, incluida la enfermedad de Alzheimer. Reivindicación 1: Compuesto de fórmula (1), en donde R¹ es hidrógeno o flúor; R² es hidrógeno o un halógeno; R³ es hidrógeno o un halógeno; D es deuterio; y sales farmacéuticamente aceptables de los mismos.The present application provides amidine compounds for the treatment of neurodegenerative or cognitive diseases, including Alzheimer's disease. Claim 1: Compound of formula (1), wherein R¹ is hydrogen or fluorine; R² is hydrogen or a halogen; R³ is hydrogen or a halogen; D is deuterium; and pharmaceutically acceptable salts thereof.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA201600778 | 2016-12-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR110406A1 true AR110406A1 (en) | 2019-03-27 |
Family
ID=65895724
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP170103599A AR110406A1 (en) | 2016-12-21 | 2017-12-20 | 6-AMINO-5-FLUORO-5- (FLUOROMETIL) -2,3,4,5-TETRAHIDROPIRIDIN-2-IL-FENIL-5- (METOXI-D₃) -PIRAZINA-2-CARBOXAMIDS AND FLUORATED DERIVATIVES OF THE SAME AS BACE1 INHIBITORS |
Country Status (1)
| Country | Link |
|---|---|
| AR (1) | AR110406A1 (en) |
-
2017
- 2017-12-20 AR ARP170103599A patent/AR110406A1/en unknown
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