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AR117118A1 - Aminoácidos grasos n-acilados para reducir la variabilidad de absorción en composiciones a base de cannabinoides - Google Patents

Aminoácidos grasos n-acilados para reducir la variabilidad de absorción en composiciones a base de cannabinoides

Info

Publication number
AR117118A1
AR117118A1 ARP190103390A ARP190103390A AR117118A1 AR 117118 A1 AR117118 A1 AR 117118A1 AR P190103390 A ARP190103390 A AR P190103390A AR P190103390 A ARP190103390 A AR P190103390A AR 117118 A1 AR117118 A1 AR 117118A1
Authority
AR
Argentina
Prior art keywords
disease
amino acid
cannabinoid
fatty amino
syndrome
Prior art date
Application number
ARP190103390A
Other languages
English (en)
Inventor
Gregory Wesner
Andrea Leone-Bay
Original Assignee
Receptor Holdings Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Receptor Holdings Inc filed Critical Receptor Holdings Inc
Publication of AR117118A1 publication Critical patent/AR117118A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/658—Medicinal preparations containing organic active ingredients o-phenolic cannabinoids, e.g. cannabidiol, cannabigerolic acid, cannabichromene or tetrahydrocannabinol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/348—Cannabaceae
    • A61K36/3482—Cannabis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Nutrition Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Medical Informatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Reivindicación 1: Un método para preparar una formulación oral de cannabinoides con menor variabilidad de absorción en sangre de cannabinoides en un sujeto que comprende agregar un cannabinoide y una cantidad eficaz de un aminoácido graso N-acilado o una sal de este a una formulación oral. Reivindicación 5: El método de la reivindicación 1, donde la formulación oral comprende 50 mg de cannabidiol (CBD) y 300 mg de aminoácido graso N-acilado o una sal de este; 10 mg de D9-Tetrahidrocannabinol (THC) y 100 mg de aminoácido graso N-acilado o una sal de este; 10 mg de THC y 200 mg de aminoácido graso N-acilado o una sal de este; 50 mg de CBD y 500 mg de aminoácido graso N-acilado o una sal de este; o 30 mg de CBD y 300 mg de aminoácido graso N-acilado o una sal de este. Reivindicación 18: El método de la reivindicación 1, donde el cannabinoide comprende un cannabinoide a base de plantas o un cannabinoide sintético. Reivindicación 19: El método de la reivindicación 1, donde la formulación oral comprende compuestos flavonoides, terpenos, o terpenoides. Reivindicación 21: El método de la reivindicación 1, donde el aminoácido graso N-acilado comprende monosodio-N-saliciloil-8-aminocaprilato, disodio-N-saliciloil-8-aminocaprilato, o ácido N-(saliciloil)-8-aminocaprílico. Reivindicación 22: El método de la reivindicación 1, donde el aminoácido graso N-acilado o sal de este comprende el compuesto de fórmula (1) donde X y Z son independientemente H, un catión monovalente, un catión metálico divalente o un catión orgánico. Reivindicación 38: El método de la reivindicación 1, donde la formulación oral se utiliza para tratar un síntoma de hipotiroidismo adquirido, gastritis aguda, adicción, ADHD, agorafobia, SIDA, anorexia relacionada con SIDA, alcoholismo, enfermedad de Alzheimer, esclerosis lateral amiotrófica (ALS), anquilosis, ansiedad, artritis, síndrome de Asperger, asma, aterosclerosis, autismo, enfermedades autoinmunes, infecciones bacterianas, trastorno bipolar, pérdida ósea, trastornos sanguíneos, lesión cerebral / apoplejía, caquexia, cáncer, síndrome del túnel carpiano, parálisis cerebral, enfermedad de disco cervical, síndrome cervicobraquial, síndrome de fatiga crónica, dolor crónico, cefalea en racimos, conjuntivitis, enfermedad de Crohn, fibrosis quística, depresión, dermatitis, diabetes, distonia, trastornos alimenticios, eccema, epilepsia, fiebre, fibromialgia, gripe, infección fúngica, trastornos gastrointestinales, glaucoma, glioma, enfermedad de Grave, enfermedad cardíaca hepatitis, herpes, enfermedad de Huntington, hipertensión, impotencia, incontinencia, mortalidad infantil, inflamación, enfermedad intestinal inflamatoria (IBD), insomnio, fibrosis hepática, enfermedad de la vaca loca, menopausia, trastornos metabólicos, cefaleas por migraña, mareos por movimiento, MRSA, esclerosis múltiple (MS), distrofia muscular, lesiones de las mucosas, síndrome de nail patella, náuseas y vómitos asociados con quimioterapia para cáncer, neuroinflamación, adicción a la nicotina, obesidad, trastorno obsesivo compulsivo (OCD), dolor, pancreatitis, trastorno del pánico, enfermedad de Parkinson, enfermedad periodontal, neuropatía periférica, dolor del miembro fantasma, alergia a hiedra venenosa, síndrome premenstrual (PMS), miopatía miotónica proximal, trastorno de estrés post-traumático (PTSD), psoriasis, enfermedad de Raynaud, síndrome de piernas inquietas, esquizofrenia, escleroderma, choque séptico, herpes zóster, enfermedad de células falciformes, convulsiones, apnea del sueño, trastornos del sueño, lesiones espinales, estrés, tartamudez, trastorno de la articulación temporomandibular (TMJ), cefaleas por tensión, tinnitus, síndrome de Tourette, recuerdos traumáticos, síndrome consuntivo, y abstinencia.
ARP190103390A 2018-11-19 2019-11-19 Aminoácidos grasos n-acilados para reducir la variabilidad de absorción en composiciones a base de cannabinoides AR117118A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201862769395P 2018-11-19 2018-11-19

Publications (1)

Publication Number Publication Date
AR117118A1 true AR117118A1 (es) 2021-07-14

Family

ID=70774480

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP190103390A AR117118A1 (es) 2018-11-19 2019-11-19 Aminoácidos grasos n-acilados para reducir la variabilidad de absorción en composiciones a base de cannabinoides

Country Status (9)

Country Link
US (2) US12303487B2 (es)
EP (1) EP3883595A4 (es)
JP (2) JP7566336B2 (es)
AR (1) AR117118A1 (es)
AU (1) AU2019385420A1 (es)
CA (1) CA3120001A1 (es)
MX (1) MX2021005807A (es)
UY (1) UY38480A (es)
WO (1) WO2020106767A1 (es)

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