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AR116116A1 - Proceso para elaborar inhibidores de jak e intermediarios de los mismos - Google Patents

Proceso para elaborar inhibidores de jak e intermediarios de los mismos

Info

Publication number
AR116116A1
AR116116A1 ARP190102521A ARP190102521A AR116116A1 AR 116116 A1 AR116116 A1 AR 116116A1 AR P190102521 A ARP190102521 A AR P190102521A AR P190102521 A ARP190102521 A AR P190102521A AR 116116 A1 AR116116 A1 AR 116116A1
Authority
AR
Argentina
Prior art keywords
compound
formula
intermediaries
developing
salt
Prior art date
Application number
ARP190102521A
Other languages
English (en)
Inventor
Gene Timothy Fass
Pierre-Jean Colson
Original Assignee
Theravance Biopharma R&D Ip Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Theravance Biopharma R&D Ip Llc filed Critical Theravance Biopharma R&D Ip Llc
Publication of AR116116A1 publication Critical patent/AR116116A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

La presente está dirigida a un proceso para preparar compuestos que son útiles como intermediarios para la preparación de agentes medicinales que tienen actividad inhibitoria de JAK. Reivindicación 1: Un proceso para preparar un compuesto de fórmula (1), o una sal del mismo, caracterizada porque X se selecciona del grupo que consiste en Br, I y Cl; PG¹ es un grupo protector de ácido carboxílico; PG² es un grupo protector de amino; y PG³ es un grupo protector de amino; en donde el proceso comprende: (a) hacer reaccionar un compuesto de fórmula (2) o una sal del mismo, con hidrazina para obtener el compuesto de la fórmula (1) y (b) opcionalmente formar una sal del compuesto de fórmula (1).
ARP190102521A 2018-09-04 2019-09-03 Proceso para elaborar inhibidores de jak e intermediarios de los mismos AR116116A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201862726600P 2018-09-04 2018-09-04

Publications (1)

Publication Number Publication Date
AR116116A1 true AR116116A1 (es) 2021-03-31

Family

ID=67957449

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP190102521A AR116116A1 (es) 2018-09-04 2019-09-03 Proceso para elaborar inhibidores de jak e intermediarios de los mismos

Country Status (15)

Country Link
US (1) US10844057B2 (es)
EP (1) EP3837253B1 (es)
JP (1) JP2021535176A (es)
KR (1) KR20210056382A (es)
CN (1) CN112638902A (es)
AR (1) AR116116A1 (es)
AU (1) AU2019335199A1 (es)
BR (1) BR112021004087A2 (es)
CA (1) CA3108848A1 (es)
IL (1) IL281152B2 (es)
MX (1) MX2021002273A (es)
PH (1) PH12021550388A1 (es)
SG (1) SG11202101785UA (es)
TW (1) TWI808250B (es)
WO (1) WO2020051135A1 (es)

Families Citing this family (12)

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UA123633C2 (uk) 2015-11-03 2021-05-05 Тереванс Байофарма Ар Енд Ді Айпі, Елелсі Сполуки інгібітору jak-кінази для лікування респіраторного захворювання
AU2018231035B2 (en) 2017-03-09 2021-09-09 Theravance Biopharma R&D Ip, Llc Fused imidazo-piperidine JAK inhibitors
AU2019336167B2 (en) 2018-09-04 2024-08-29 Theravance Biopharma R&D Ip, Llc Dimethyl amino azetidine amides as JAK inhibitors
US10836763B2 (en) 2018-09-04 2020-11-17 Theravance Biopharma R&D Ip, Llc 5 to 7 membered heterocyclic amides as JAK inhibitors
TW202144343A (zh) 2020-03-02 2021-12-01 美商施萬生物製藥研發 Ip有限責任公司 Jak抑制劑化合物之結晶水合物
TW202207921A (zh) * 2020-05-08 2022-03-01 美商施萬生物製藥研發Ｉｐ有限責任公司 以二甲基胺基吖呾醯胺化合物治療受冠狀病毒感染的患者之方法
WO2022081872A1 (en) * 2020-10-16 2022-04-21 Gb008, Inc. Janus kinase inhibitors
WO2022271604A1 (en) 2021-06-21 2022-12-29 Theravance Biopharma R&D Ip, Llc Method of treating a patient infected with a coronavirus and having a baseline level of crp below 150 mg/l
CA3223194A1 (en) 2021-06-25 2022-12-29 Theravance Biopharma R&D Ip, Llc Imidazolo indazole compounds as jak inhibitors
CN118401508A (zh) * 2021-12-17 2024-07-26 株式会社大熊制药 (2R,3S)-2-(3-(4,5-二氯-1H-苯并[d]咪唑-1-基)丙基)哌啶-3-醇的新酸加成盐及晶形
JP2025515078A (ja) 2022-05-05 2025-05-13 セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー 噴霧経口吸入による送達のためのネズルシチニブ
WO2023230236A1 (en) * 2022-05-26 2023-11-30 Theravance Biopharma R&D Ip, Llc Process for preparing jak inhibitors and intermediates thereof

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TWI262914B (en) 1999-07-02 2006-10-01 Agouron Pharma Compounds and pharmaceutical compositions for inhibiting protein kinases
US7872014B2 (en) 2003-07-23 2011-01-18 Exelixis, Inc. Anaplastic lymphoma kinase modulators and methods of use
US20050090529A1 (en) 2003-07-31 2005-04-28 Pfizer Inc 3,5 Disubstituted indazole compounds with nitrogen-bearing 5-membered heterocycles, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation
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US10836763B2 (en) 2018-09-04 2020-11-17 Theravance Biopharma R&D Ip, Llc 5 to 7 membered heterocyclic amides as JAK inhibitors
AU2019336167B2 (en) 2018-09-04 2024-08-29 Theravance Biopharma R&D Ip, Llc Dimethyl amino azetidine amides as JAK inhibitors
AU2019373059A1 (en) 2018-10-29 2021-05-06 Theravance Biopharma R&D Ip, Llc 2-azabicyclo hexane compound as JAK inhibitor
KR102873783B1 (ko) 2019-02-25 2025-10-21 메디노 파마슈티컬 테크놀로지 (주하이) 컴퍼니 리미티드 Jak 억제제 화합물 및 그 사용

Also Published As

Publication number Publication date
SG11202101785UA (en) 2021-03-30
BR112021004087A2 (pt) 2021-05-25
CN112638902A (zh) 2021-04-09
CA3108848A1 (en) 2020-03-12
PH12021550388A1 (en) 2021-11-08
EP3837253B1 (en) 2023-06-07
AU2019335199A1 (en) 2021-03-11
US20200071324A1 (en) 2020-03-05
US10844057B2 (en) 2020-11-24
EP3837253A1 (en) 2021-06-23
IL281152B1 (en) 2023-08-01
EP3837253C0 (en) 2023-06-07
IL281152A (en) 2021-04-29
KR20210056382A (ko) 2021-05-18
TW202024074A (zh) 2020-07-01
IL281152B2 (en) 2023-12-01
WO2020051135A1 (en) 2020-03-12
MX2021002273A (es) 2021-05-27
TWI808250B (zh) 2023-07-11
JP2021535176A (ja) 2021-12-16

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