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AR114326A1 - Sistemas y métodos para detección modo falla en cromatografía de proceso - Google Patents

Sistemas y métodos para detección modo falla en cromatografía de proceso

Info

Publication number
AR114326A1
AR114326A1 ARP190100364A ARP190100364A AR114326A1 AR 114326 A1 AR114326 A1 AR 114326A1 AR P190100364 A ARP190100364 A AR P190100364A AR P190100364 A ARP190100364 A AR P190100364A AR 114326 A1 AR114326 A1 AR 114326A1
Authority
AR
Argentina
Prior art keywords
methods
systems
failure mode
mode detection
process chromatography
Prior art date
Application number
ARP190100364A
Other languages
English (en)
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of AR114326A1 publication Critical patent/AR114326A1/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3804—Affinity chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/42—Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
    • B01D15/424—Elution mode
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/74—Optical detectors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/86—Signal analysis
    • G01N30/8651—Recording, data aquisition, archiving and storage
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/86—Signal analysis
    • G01N30/8675—Evaluation, i.e. decoding of the signal into analytical information
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/20—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the sorbent material
    • B01D15/206—Packing or coating
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/32—Bonded phase chromatography
    • B01D15/325—Reversed phase
    • B01D15/327—Reversed phase with hydrophobic interaction
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
    • B01D15/361—Ion-exchange
    • B01D15/363—Anion-exchange
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N2030/022—Column chromatography characterised by the kind of separation mechanism
    • G01N2030/027—Liquid chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/50—Conditioning of the sorbent material or stationary liquid
    • G01N30/56—Packing methods or coating methods
    • G01N2030/562—Packing methods or coating methods packing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/889—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 monitoring the quality of the stationary phase; column performance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/50—Conditioning of the sorbent material or stationary liquid
    • G01N30/56—Packing methods or coating methods

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Organic Chemistry (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Library & Information Science (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Se proporcionan sistemas y métodos útiles para predecir o detectar un mal funcionamiento en un proceso de cromatografía en tiempo real. En algunas realizaciones, la revelación proporciona sistemas y métodos para detectar un perfil atípico en un cromatograma de proceso en cromatografía de intercambio iónico de un producto biológico.
ARP190100364A 2018-02-15 2019-02-14 Sistemas y métodos para detección modo falla en cromatografía de proceso AR114326A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201862631167P 2018-02-15 2018-02-15

Publications (1)

Publication Number Publication Date
AR114326A1 true AR114326A1 (es) 2020-08-19

Family

ID=65635819

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP190100364A AR114326A1 (es) 2018-02-15 2019-02-14 Sistemas y métodos para detección modo falla en cromatografía de proceso

Country Status (15)

Country Link
US (3) US11499951B2 (es)
EP (1) EP3752826A1 (es)
JP (3) JP7410862B2 (es)
KR (2) KR20250091326A (es)
CN (2) CN117761227A (es)
AR (1) AR114326A1 (es)
AU (3) AU2019221563B2 (es)
BR (1) BR112020015240A2 (es)
CA (1) CA3088994A1 (es)
EA (1) EA202091717A1 (es)
IL (2) IL276177B1 (es)
MX (2) MX2020008534A (es)
SG (1) SG11202007078WA (es)
TW (3) TWI795527B (es)
WO (1) WO2019161012A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11499951B2 (en) 2018-02-15 2022-11-15 Regeneron Pharmaceuticals, Inc. Systems and methods for failure mode detection in process chromatography
CN117907511B (zh) * 2024-03-20 2024-06-14 浙江灵析精仪科技发展有限公司 一种多组分重叠峰的自动化解析方法、装置及电子设备
CN118443858B (zh) * 2024-07-08 2024-10-29 江苏权正检验检测有限公司 基于人工智能的高效液相色谱仪故障分析方法

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AU2003258414A1 (en) * 2002-08-23 2004-03-11 Mcmaster University Methods and compounds for controlling the morphology and shrinkage of silica derived from polyol-modified silanes
JP2006292446A (ja) * 2005-04-07 2006-10-26 Shimadzu Corp ガスクロマトグラフ装置
EP1957969B1 (en) * 2005-12-06 2017-06-28 Pall Corporation Method for testing chromatography media and devices
US7681089B2 (en) * 2007-02-20 2010-03-16 Dot Hill Systems Corporation Redundant storage controller system with enhanced failure analysis capability
JP4850165B2 (ja) * 2007-11-02 2012-01-11 パナソニック株式会社 クロマトグラフィー検査装置およびクロマトグラフィー試験片の劣化判定方法
CA2712732C (en) * 2008-01-25 2018-11-27 Biogen Idec Ma Inc. Automated system and method for monitoring chromatography column performance, and applications thereof
US9095291B2 (en) * 2008-08-07 2015-08-04 University Of Massachusetts Spectroscopic sensors
US8410928B2 (en) * 2008-08-15 2013-04-02 Biogen Idec Ma Inc. Systems and methods for evaluating chromatography column performance
WO2010025240A2 (en) * 2008-09-01 2010-03-04 Andrew Mark Wolters Separation technology method and identification of error
JP5262482B2 (ja) * 2008-09-12 2013-08-14 株式会社島津製作所 ガスクロマトグラフ装置
WO2011042024A1 (en) * 2009-10-09 2011-04-14 Symphogen A/S Pharmacokinetic assessment of recombinant proteins in complex biological samples by pk-chromatography
JP5345970B2 (ja) 2010-04-08 2013-11-20 株式会社日立ハイテクノロジーズ 液体クロマトグラフ装置
US9442098B2 (en) * 2012-08-02 2016-09-13 Waters Technologies Corporation Chromatographic system quality control reference materials
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Also Published As

Publication number Publication date
KR20250091326A (ko) 2025-06-20
CN111819439B (zh) 2023-11-28
CA3088994A1 (en) 2019-08-22
TWI867847B (zh) 2024-12-21
MX2024006827A (es) 2024-06-19
AU2024227672A1 (en) 2024-11-14
US11499951B2 (en) 2022-11-15
BR112020015240A2 (pt) 2021-01-26
CN111819439A (zh) 2020-10-23
AU2019221563A1 (en) 2020-08-13
AU2019221563B2 (en) 2022-08-04
AU2022259817A1 (en) 2022-12-01
JP2024023764A (ja) 2024-02-21
IL276177B1 (en) 2025-12-01
TWI795527B (zh) 2023-03-11
TW202409561A (zh) 2024-03-01
US20240345048A1 (en) 2024-10-17
IL324756A (en) 2026-01-01
JP2025178410A (ja) 2025-12-05
TWI823782B (zh) 2023-11-21
IL276177A (en) 2020-09-30
JP7410862B2 (ja) 2024-01-10
US20230020627A1 (en) 2023-01-19
US12025599B2 (en) 2024-07-02
KR20200121796A (ko) 2020-10-26
SG11202007078WA (en) 2020-08-28
TW202324439A (zh) 2023-06-16
TW201945966A (zh) 2019-12-01
JP7752673B2 (ja) 2025-10-10
WO2019161012A1 (en) 2019-08-22
KR102823730B1 (ko) 2025-06-23
US20190248850A1 (en) 2019-08-15
AU2022259817B2 (en) 2024-11-07
CN117761227A (zh) 2024-03-26
EP3752826A1 (en) 2020-12-23
JP2021514058A (ja) 2021-06-03
EA202091717A1 (ru) 2021-01-14
MX2020008534A (es) 2020-09-18

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