AR114029A2 - Compuestos adecuados como precursores de compuestos que son útiles para obtener imágenes de depósitos amiloides, usos y procesos - Google Patents
Compuestos adecuados como precursores de compuestos que son útiles para obtener imágenes de depósitos amiloides, usos y procesosInfo
- Publication number
- AR114029A2 AR114029A2 ARP180103297A ARP180103297A AR114029A2 AR 114029 A2 AR114029 A2 AR 114029A2 AR P180103297 A ARP180103297 A AR P180103297A AR P180103297 A ARP180103297 A AR P180103297A AR 114029 A2 AR114029 A2 AR 114029A2
- Authority
- AR
- Argentina
- Prior art keywords
- compound
- useful
- amyloid deposits
- compounds
- processes
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 10
- 238000000034 method Methods 0.000 title abstract 4
- 239000002243 precursor Substances 0.000 title abstract 4
- 208000037259 Amyloid Plaque Diseases 0.000 title abstract 3
- 208000024827 Alzheimer disease Diseases 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- FXERARHKNULYEN-HUYCHCPVSA-N 2-[6-(18F)fluoranyl-5-(methylamino)pyridin-2-yl]-1-benzofuran-5-ol Chemical compound [18F]C1=C(C=CC(=N1)C=1OC2=C(C=1)C=C(C=C2)O)NC FXERARHKNULYEN-HUYCHCPVSA-N 0.000 abstract 1
- ACZGCWSMSTYWDQ-UHFFFAOYSA-N 3h-1-benzofuran-2-one Chemical compound C1=CC=C2OC(=O)CC2=C1 ACZGCWSMSTYWDQ-UHFFFAOYSA-N 0.000 abstract 1
- -1 [6- (5-ethoxymethoxy-benzofuran-2-yl) -2-nitro-pyridin-3-yl] -methyl acid tert-butyl ester Chemical compound 0.000 abstract 1
- 210000004556 brain Anatomy 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000003384 imaging method Methods 0.000 abstract 1
- 238000011503 in vivo imaging Methods 0.000 abstract 1
- 238000005259 measurement Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000002600 positron emission tomography Methods 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/002—Heterocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/76—Nitrogen atoms to which a second hetero atom is attached
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Furan Compounds (AREA)
Abstract
La presente se refiere a derivados que son adecuados como precursores de compuestos útiles para obtener imágenes de depósitos amiloides en pacientes vivos, a sus composiciones, a métodos de uso y a procesos para preparar dichos compuestos. Los compuestos que derivan de estos precursores son útiles en métodos de imaginología in vivo de depósitos amiloides en el cerebro para permitir el diagnóstico ante mortem de la enfermedad de Alzheimer mediante tomografía por emisión de positrones (PET) así como la medición de la eficacia clínica de agentes terapéuticos para la enfermedad de Alzheimer. Además, la presente también divulga los compuestos precursores en forma cristalina. Reivindicación 1: Un compuesto o una de sus sales, donde el compuesto es el éster terc-butílico del ácido [6-(5-etoximetoxi-benzofuran-2-il)-2-nitro-piridin-3-il]-metil-carbámico. Reivindicación 5: El compuesto o una de sus sales de acuerdo con la reivindicación 1, en una forma cristalina que comprende los picos de difracción siguientes: 11,27; 12,00; 13,51; 15,53; 16,82; 17,91; y 23,72 º2q. Reivindicación 8: El uso de acuerdo con la reivindicación 6 ó 7, donde el compuesto marcado es 2-(6-[¹⁸F]-flúor-5-metilamino-piridin-2-il)-benzofuran-5-ol o una de sus sales.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9285108P | 2008-08-29 | 2008-08-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR114029A2 true AR114029A2 (es) | 2020-07-15 |
Family
ID=41721733
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP090103323A AR073230A1 (es) | 2008-08-29 | 2009-08-28 | Derivados del acido benzofuran-piridin carbamico, utiles en la preparacion de compuestos marcados, proceso para prepararlos y proceso para preparar precursores de sintesis. |
| ARP180103297A AR114029A2 (es) | 2008-08-29 | 2018-11-12 | Compuestos adecuados como precursores de compuestos que son útiles para obtener imágenes de depósitos amiloides, usos y procesos |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP090103323A AR073230A1 (es) | 2008-08-29 | 2009-08-28 | Derivados del acido benzofuran-piridin carbamico, utiles en la preparacion de compuestos marcados, proceso para prepararlos y proceso para preparar precursores de sintesis. |
Country Status (22)
| Country | Link |
|---|---|
| US (3) | US8193363B2 (es) |
| EP (1) | EP2328891B1 (es) |
| JP (1) | JP5613669B2 (es) |
| KR (1) | KR101648848B1 (es) |
| CN (3) | CN104478862B (es) |
| AR (2) | AR073230A1 (es) |
| AU (1) | AU2009286176B2 (es) |
| BR (1) | BRPI0917147B8 (es) |
| CA (1) | CA2735497C (es) |
| CL (1) | CL2011000420A1 (es) |
| CO (1) | CO6341628A2 (es) |
| EA (1) | EA019093B1 (es) |
| EC (1) | ECSP11010850A (es) |
| ES (1) | ES2627769T3 (es) |
| IL (1) | IL211188A0 (es) |
| MX (1) | MX2011001918A (es) |
| NZ (1) | NZ591446A (es) |
| PE (1) | PE20110393A1 (es) |
| TW (1) | TW201014848A (es) |
| UY (1) | UY32076A (es) |
| WO (1) | WO2010024769A1 (es) |
| ZA (1) | ZA201102284B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8193363B2 (en) | 2008-08-29 | 2012-06-05 | Astrazeneca Ab | Compounds suitable as precursors to compounds that are useful for imaging amyloid deposits |
| WO2012017891A1 (ja) * | 2010-08-06 | 2012-02-09 | 国立大学法人京都大学 | ピリジルベンゾフラン誘導体 |
| US10098859B2 (en) | 2012-09-05 | 2018-10-16 | Amri Ssci, Llc | Cocrystals of p-coumaric acid |
| CA2894994C (en) | 2012-12-21 | 2019-11-12 | National Institute Of Radiological Sciences | Compounds for imaging tau proteins that accumulate in brain |
| WO2016029146A1 (en) * | 2014-08-22 | 2016-02-25 | University Of Washington | Specific inhibitors of methionyl-trna synthetase |
| MX2018006266A (es) * | 2015-11-20 | 2019-05-06 | Navidea Biopharmaceuticals Inc | Formulaciones de benzofuranos 2-heteroaril-sustituidos. |
| US12116364B2 (en) | 2018-05-09 | 2024-10-15 | Aprinoia Therapeutics Inc. | Heteroaryl compounds and uses thereof |
| KR20220100921A (ko) | 2019-11-13 | 2022-07-18 | 아프리노이아 테라퓨틱스 리미티드 | 타우 단백질 응집체를 분해하기 위한 화합물 및 이의 용도 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1041525A (en) | 1964-11-11 | 1966-09-07 | Belge Produits Chimiques Sa | Benzofuran derivatives and processes for preparing the same |
| WO1995017095A1 (en) | 1993-12-21 | 1995-06-29 | Eli Lilly And Company | Methods for the treatment or prevention of conditions associated with amyloidogenic reptides |
| PL357433A1 (en) * | 1999-10-15 | 2004-07-26 | F.Hoffmann-La Roche Ag | Benzodiazepine derivatives as metabotropic glutamate receptor antagonists |
| FR2800069A1 (fr) * | 1999-10-22 | 2001-04-27 | Centre Nat Rech Scient | 3-amino-2,2-di-c-alkyl-1,4-butyrolactones et 1,4- thiobutyrolactones n-substituees utiles comme stimulant de l'activite de l'acide gamma-aminobutyrique et leur procede de preparation |
| EP1351936A1 (en) | 2001-01-15 | 2003-10-15 | Glaxo Group Limited | Aryl piperidine and piperazine derivatives as inducers of ldl-receptor expression |
| JP4307001B2 (ja) | 2001-03-14 | 2009-08-05 | キヤノン株式会社 | 金属配位化合物、電界発光素子及び表示装置 |
| GB0130305D0 (en) | 2001-12-19 | 2002-02-06 | Amersham Plc | Compounds for imaging alzheimers disease |
| AU2003258022A1 (en) | 2002-08-02 | 2004-02-23 | Genesoft Pharmaceuticals, Inc. | Biaryl compounds having anti-infective activity |
| US20040223912A1 (en) * | 2003-05-07 | 2004-11-11 | Montalto Michael Christopher | Compositions and methods for non-invasive imaging of soluble beta-amyloid |
| WO2004100998A2 (en) * | 2003-05-07 | 2004-11-25 | General Electric Company | Compositions and methods for non-invasive imaging of soluble beta-amyloid |
| EP1644365A2 (en) | 2003-07-02 | 2006-04-12 | Biofocus Discovery Ltd | Pyrazine and pyridine derivatives as rho kinase inhibitors |
| UA91341C2 (ru) * | 2004-07-15 | 2010-07-26 | Амр Текнолоджи, Інк. | Арил- и гетероарилзамещенные тетрагидроизохинолины и их применение для блокирования обратного захвата норэпинефрина, допамина и серотонина |
| US20060223849A1 (en) * | 2005-03-14 | 2006-10-05 | Mjalli Adnan M | Benzazole derivatives, compositions, and methods of use as beta-secretase inhibitors |
| KR101286569B1 (ko) | 2005-07-04 | 2013-07-23 | 하이 포인트 파마슈티칼스, 엘엘씨 | 신규 약제 |
| EP1945622B1 (en) * | 2005-10-11 | 2011-12-28 | University of Pittsburgh - Of the Commonwealth System of Higher Education | Isotopically-labeled benzofuran compounds as imagingagents for amyloidogenic proteins |
| TW200736252A (en) * | 2006-01-27 | 2007-10-01 | Astrazeneca Ab | Novel heteroaryl substituted benzothiazoles |
| JPWO2008068974A1 (ja) * | 2006-12-05 | 2010-03-18 | 国立大学法人 長崎大学 | オーロン誘導体含有診断用組成物 |
| JP4328820B2 (ja) | 2007-01-10 | 2009-09-09 | 田辺三菱製薬株式会社 | 医薬組成物 |
| TW200901998A (en) * | 2007-03-06 | 2009-01-16 | Astrazeneca Ab | Novel 2-heteroaryl substituted benzothiophenes and benzofuranes |
| US8193363B2 (en) * | 2008-08-29 | 2012-06-05 | Astrazeneca Ab | Compounds suitable as precursors to compounds that are useful for imaging amyloid deposits |
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2009
- 2009-08-20 US US12/544,556 patent/US8193363B2/en active Active
- 2009-08-27 TW TW098128873A patent/TW201014848A/zh unknown
- 2009-08-27 UY UY0001032076A patent/UY32076A/es not_active Application Discontinuation
- 2009-08-28 JP JP2011524942A patent/JP5613669B2/ja active Active
- 2009-08-28 EP EP09810319.5A patent/EP2328891B1/en active Active
- 2009-08-28 MX MX2011001918A patent/MX2011001918A/es active IP Right Grant
- 2009-08-28 EA EA201100267A patent/EA019093B1/ru not_active IP Right Cessation
- 2009-08-28 KR KR1020117004579A patent/KR101648848B1/ko active Active
- 2009-08-28 CN CN201410653507.7A patent/CN104478862B/zh active Active
- 2009-08-28 AR ARP090103323A patent/AR073230A1/es active IP Right Grant
- 2009-08-28 PE PE2011000219A patent/PE20110393A1/es not_active Application Discontinuation
- 2009-08-28 ES ES09810319.5T patent/ES2627769T3/es active Active
- 2009-08-28 NZ NZ591446A patent/NZ591446A/xx not_active IP Right Cessation
- 2009-08-28 BR BRPI0917147A patent/BRPI0917147B8/pt active IP Right Grant
- 2009-08-28 CN CN200980142788.7A patent/CN102197036B/zh active Active
- 2009-08-28 AU AU2009286176A patent/AU2009286176B2/en active Active
- 2009-08-28 CA CA2735497A patent/CA2735497C/en active Active
- 2009-08-28 CN CN201410655681.5A patent/CN104447710A/zh active Pending
- 2009-08-28 WO PCT/SE2009/050972 patent/WO2010024769A1/en not_active Ceased
-
2011
- 2011-02-10 IL IL211188A patent/IL211188A0/en unknown
- 2011-02-21 CO CO11020875A patent/CO6341628A2/es not_active Application Discontinuation
- 2011-02-25 CL CL2011000420A patent/CL2011000420A1/es unknown
- 2011-02-28 EC EC2011010850A patent/ECSP11010850A/es unknown
- 2011-03-28 ZA ZA2011/02284A patent/ZA201102284B/en unknown
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2012
- 2012-06-04 US US13/487,349 patent/US8653274B2/en active Active
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2014
- 2014-01-07 US US14/149,563 patent/US9309267B2/en active Active
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2018
- 2018-11-12 AR ARP180103297A patent/AR114029A2/es active IP Right Grant
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