AR103316A1 - VIRAL TERMINASE DIHYDROQUINAZOLINE INHIBITORS - Google Patents
VIRAL TERMINASE DIHYDROQUINAZOLINE INHIBITORSInfo
- Publication number
- AR103316A1 AR103316A1 ARP150104334A ARP150104334A AR103316A1 AR 103316 A1 AR103316 A1 AR 103316A1 AR P150104334 A ARP150104334 A AR P150104334A AR P150104334 A ARP150104334 A AR P150104334A AR 103316 A1 AR103316 A1 AR 103316A1
- Authority
- AR
- Argentina
- Prior art keywords
- dihydroquinazoline
- inhibitors
- deuterium
- viral
- terminase
- Prior art date
Links
- NTURVSFTOYPGON-UHFFFAOYSA-N Dihydroquinazoline Chemical compound C1=CC=C2C=NCNC2=C1 NTURVSFTOYPGON-UHFFFAOYSA-N 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title 1
- 108010040614 terminase Proteins 0.000 title 1
- 230000003612 virological effect Effects 0.000 title 1
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 abstract 3
- 229910052805 deuterium Inorganic materials 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 208000036142 Viral infection Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000009385 viral infection Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C07D239/84—Nitrogen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente solicitud se refiere a moduladores de dihidroquinazolina de una infección viral, composiciones farmacéuticas de los mismos y métodos de uso de los mismos. Reivindicación 1: Un compuesto caracterizado por la fórmula estructural (1) o una sal del mismo, en donde: R¹ y R² se seleccionan independientemente del grupo que consiste en -CH₃, -CH₂D, -CD₂H y -CD₃; R³ - R²⁵ se seleccionan independientemente del grupo que consiste en hidrógeno y deuterio; y al menos uno de R¹ - R²⁵ es deuterio o contiene deuterio.The present application relates to dihydroquinazoline modulators of a viral infection, pharmaceutical compositions thereof and methods of use thereof. Claim 1: A compound characterized by the structural formula (1) or a salt thereof, wherein: R¹ and R² are independently selected from the group consisting of -CH₃, -CH₂D, -CD₂H and -CD₃; R³ - R²⁵ are independently selected from the group consisting of hydrogen and deuterium; and at least one of R¹ - R²⁵ is deuterium or contains deuterium.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462097443P | 2014-12-29 | 2014-12-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR103316A1 true AR103316A1 (en) | 2017-05-03 |
Family
ID=56284952
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP150104334A AR103316A1 (en) | 2014-12-29 | 2015-12-29 | VIRAL TERMINASE DIHYDROQUINAZOLINE INHIBITORS |
Country Status (3)
| Country | Link |
|---|---|
| AR (1) | AR103316A1 (en) |
| TW (1) | TW201629043A (en) |
| WO (1) | WO2016109360A1 (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10851112B2 (en) | 2016-08-08 | 2020-12-01 | Medshine Discovery Inc. | Anti-HCMV virus compound |
| AU2019218150B2 (en) * | 2018-02-08 | 2021-05-13 | Phaeno Therapeutics Co., Ltd. | Crystal form of 3,4-dihydrothieno[3,2-d]pyrimidine compound and preparation method therefor |
| CN115322157B (en) * | 2022-06-02 | 2023-12-05 | 浙江车头制药股份有限公司 | Letermopevir intermediate compound, preparation method and application thereof |
| CN117229223A (en) * | 2022-06-08 | 2023-12-15 | 苏州远智医药科技有限公司 | Heterocyclic derivative and pharmaceutical composition and application thereof |
| CN117486808A (en) * | 2023-11-06 | 2024-02-02 | 北京康立生医药技术开发有限公司 | A new preparation method for key intermediates of letermovir |
| CN117658928A (en) * | 2023-11-07 | 2024-03-08 | 北京康立生医药技术开发有限公司 | A new preparation method of drug intermediates for preventing CMV infection |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102005027517A1 (en) * | 2005-06-15 | 2006-12-21 | Bayer Healthcare Ag | Process for the preparation of dihydroquinazolines |
| CA2768043A1 (en) * | 2009-07-27 | 2011-02-10 | Auspex Pharmaceuticals, Inc. | Cyclopropyl modulators of p2y12 receptor |
| DE102012101659A1 (en) * | 2012-02-29 | 2013-08-29 | Aicuris Gmbh & Co. Kg | Salts of a dihydroquinazoline derivative |
| JP2015531776A (en) * | 2012-09-04 | 2015-11-05 | セルジーン コーポレイション | Isotopologue of 3- (5-amino-2-methyl-4-oxoquinazolin-3 (4H) -yl) piperidine-2,6-dione and process for producing the same |
-
2015
- 2015-12-27 WO PCT/US2015/067542 patent/WO2016109360A1/en not_active Ceased
- 2015-12-29 TW TW104144198A patent/TW201629043A/en unknown
- 2015-12-29 AR ARP150104334A patent/AR103316A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| TW201629043A (en) | 2016-08-16 |
| WO2016109360A1 (en) | 2016-07-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR103316A1 (en) | VIRAL TERMINASE DIHYDROQUINAZOLINE INHIBITORS | |
| CL2015003615A1 (en) | Substituted nucleosides, nucleotides and analogs thereof. | |
| CO2018004124A2 (en) | Heterocyclic compounds | |
| MX2017006266A (en) | HETEROARILO COMPOUNDS AS INHIBITORS OF KINASES ASSOCIATED WITH THE INTERLEUCINE 1 (IRAK) RECEIVER AND ITS USES. | |
| MX2016003199A (en) | AZAPIRIDONE COMPOUNDS AND USES OF THE SAME. | |
| EA201591455A1 (en) | DERIVATIVES OF BENZIMIDAZOLONE AS A BROMODOMENE INHIBITORS | |
| BR112017006253A2 (en) | new compounds | |
| CR20150454A (en) | AMIDA COMPOUNDS FOR HIV TREATMENT | |
| EA201492214A1 (en) | HEPATITIS C VIRUS INHIBITORS | |
| BR112017000246A2 (en) | compound, pharmaceutically acceptable salt of a compound, pharmaceutical composition, and use of a compound or salt | |
| AR094812A1 (en) | DERIVED FROM MONOCYCLIC PYRIDINE AS AN FGFR INHIBITOR | |
| BR112016014020A8 (en) | tetrahydropyridopyrazines modulators of gpr6. | |
| AR097082A1 (en) | THERAPEUTICALLY ACTIVE COMPOUNDS AND THEIR METHODS OF USE | |
| AR104174A1 (en) | OXADIAZOLS REPLACED WITH DEUTERIO | |
| EA201790571A1 (en) | PYRROPHYRIMIDINES FOR APPLICATION IN INFECTION CAUSED BY THE FLU VIRUS | |
| BR112017006240A2 (en) | new compounds | |
| AR103355A1 (en) | MODULATORS OF CYCLOPROPANOCARBOXAMIDE OF THE TRANSMEMBRANE CHEMICAL FIBROSIS DRIVING REGULATOR | |
| BR112015018509A2 (en) | imidazo pyridine compounds | |
| EA201592184A1 (en) | 4'-FLUOR-2'-METHYL SUBSTITUTED NUCLEOSIDE DERIVATIVES | |
| NZ709986A (en) | Pharmaceutical compositions comprising nitroxyl donors | |
| BR112015016325A2 (en) | COMPOUND, PHARMACEUTICAL COMPOSITION, AND USES OF A COMPOSITION, COMPOUND, PRO-DRUG, OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | |
| CO2018010787A2 (en) | Griseofulvin compound | |
| AR103317A1 (en) | MELATONINE RECEPTORS DIHYDROBENZOFURAN CYCLOPROPIL MODULATORS | |
| BR112017018305A2 (en) | deacetoxytubulisine h and analogs thereof | |
| MX2018009459A (en) | Sulfonamide derivative and pharmaceutical composition containing same. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |