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AR102331A1 - Activación del factor x - Google Patents

Activación del factor x

Info

Publication number
AR102331A1
AR102331A1 ARP150102586A ARP150102586A AR102331A1 AR 102331 A1 AR102331 A1 AR 102331A1 AR P150102586 A ARP150102586 A AR P150102586A AR P150102586 A ARP150102586 A AR P150102586A AR 102331 A1 AR102331 A1 AR 102331A1
Authority
AR
Argentina
Prior art keywords
factor
anion exchange
exchange material
activation
activating
Prior art date
Application number
ARP150102586A
Other languages
English (en)
Inventor
Horling Franziska
Dockal Michael
Bhm Ernst
Fiedler Christian
Gatternig Thomas
Hasslacher Meinhard
Original Assignee
Baxalta Inc
Baxalta GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxalta Inc, Baxalta GmbH filed Critical Baxalta Inc
Publication of AR102331A1 publication Critical patent/AR102331A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6432—Coagulation factor Xa (3.4.21.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21006—Coagulation factor Xa (3.4.21.6)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Se revelan métodos y sistemas para activar el Factor X. Reivindicación 1: Un método para activar el Factor X de Coagulación (FX) caracterizada porque comprende: a) poner en una solución acuosa que comprende FX con un material de intercambio de aniones en condiciones de unión durante un período de contacto; y b) eluir el FX activado (FXa) desde el material de intercambio de aniones con un tampón de elución.
ARP150102586A 2014-08-12 2015-08-11 Activación del factor x AR102331A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201462036402P 2014-08-12 2014-08-12

Publications (1)

Publication Number Publication Date
AR102331A1 true AR102331A1 (es) 2017-02-22

Family

ID=54062803

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP150102586A AR102331A1 (es) 2014-08-12 2015-08-11 Activación del factor x

Country Status (10)

Country Link
US (1) US10036002B2 (es)
EP (1) EP3180355B1 (es)
JP (2) JP6791842B2 (es)
CN (1) CN107109391B (es)
AR (1) AR102331A1 (es)
AU (1) AU2015301712B8 (es)
ES (1) ES2752177T3 (es)
MX (1) MX376367B (es)
TW (1) TWI684599B (es)
WO (1) WO2016025601A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3590528A1 (en) * 2018-07-06 2020-01-08 Octapharma AG Fx activation process and its use in the preparation of a fxa composition

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19531637A1 (de) * 1995-08-28 1997-03-06 Immuno Ag Pharmazeutische Zusammensetzung zur Behandlung von Blutgerinnungsstörugnen, Verfahren zur Herstellung derselben und deren Verwendung
DE19710190A1 (de) * 1997-03-12 1998-09-17 Immuno Ag Aktivierter Vitamin K-abhängiger Blutfaktor und Verfahren zu dessen Herstellung
EP1644030B1 (en) * 2003-07-01 2009-10-28 Novo Nordisk Health Care AG Liquid, aqueous pharmaceutical composition of factor vii polypeptides
JP2007055899A (ja) * 2003-10-27 2007-03-08 Chemo Sero Therapeut Res Inst 血液凝固第ｘ因子を主剤とする血液凝固異常に基づく疾患の治療・予防用医薬組成物
GB0710321D0 (en) * 2007-05-30 2007-07-11 Nhs Blood & Transplant Method
PL2748179T3 (pl) * 2011-10-14 2022-04-11 Takeda Pharmaceutical Company Limited Oczyszczanie białka metodą anionowej chromatografii jonowymiennej
WO2013053888A1 (en) * 2011-10-14 2013-04-18 Baxter International Inc. Protein purification by anion exchange chromatography
US10202417B2 (en) * 2013-03-15 2019-02-12 Baxalta Incorporated Purification method for vitamin K dependent proteins by anion exchange chromatography

Also Published As

Publication number Publication date
JP2020156505A (ja) 2020-10-01
MX376367B (es) 2025-03-07
ES2752177T3 (es) 2020-04-03
JP6791842B2 (ja) 2020-11-25
US20160046922A1 (en) 2016-02-18
EP3180355B1 (en) 2019-07-31
WO2016025601A1 (en) 2016-02-18
TWI684599B (zh) 2020-02-11
TW201613957A (en) 2016-04-16
JP2017526669A (ja) 2017-09-14
MX2017001929A (es) 2017-06-30
AU2015301712B2 (en) 2020-03-26
AU2015301712A8 (en) 2020-04-16
AU2015301712B8 (en) 2020-04-16
CN107109391A (zh) 2017-08-29
EP3180355A1 (en) 2017-06-21
CN107109391B (zh) 2021-04-13
AU2015301712A1 (en) 2017-03-23
US10036002B2 (en) 2018-07-31

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