AR102246A1 - Compuestos aromáticos sustituidos y composiciones farmacéuticas para la prevención y tratamiento de osteoporosis, usos - Google Patents
Compuestos aromáticos sustituidos y composiciones farmacéuticas para la prevención y tratamiento de osteoporosis, usosInfo
- Publication number
- AR102246A1 AR102246A1 ARP150103294A ARP150103294A AR102246A1 AR 102246 A1 AR102246 A1 AR 102246A1 AR P150103294 A ARP150103294 A AR P150103294A AR P150103294 A ARP150103294 A AR P150103294A AR 102246 A1 AR102246 A1 AR 102246A1
- Authority
- AR
- Argentina
- Prior art keywords
- osteoporosis
- prevention
- treatment
- pharmaceutical compositions
- aromatic compounds
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
- C07C57/32—Phenylacetic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
- C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
- C07C59/52—Unsaturated compounds containing hydroxy or O-metal groups a hydroxy or O-metal group being bound to a carbon atom of a six-membered aromatic ring
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Physical Education & Sports Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Reivindicación 1: Un método para la prevención y/o el tratamiento de la osteoporosis, que comprende la etapa de administrarle a un sujeto que lo necesita un compuesto representado por la fórmula (1), o una sal farmacéuticamente aceptable de este, en donde A es alquilo C₅, alquilo C₆, alquenilo C₅, alquenilo C₆, C(O)-(CH₂)ₙ-CH₃ o CH(OH)-(CH₂)ₙ-CH₃ en donde n es 3 ó 4; R¹ es H, F u OH; R² es H, F, OH, alquilo C₅, alquilo C₆, alquenilo C₅ alquenilo C₆, C(O)-(CH₂)ₙ-CH₃ o CH(OH)-(CH₂)ₙ-CH₃ en donde n es 3 ó 4; R³ es H, F, OH o CH₂Ph; R⁴ es H, F u OH; Q es 1) (CH₂)ₘC(O)OH en donde m es 1 ó 2, 2) CH(F)-C(O)OH, 3) CF₂-C(O)OH, o 4) C(O)-C(O)OH. Reivindicación 8: El método de cualquiera de las reivindicaciones de 1 a 7 caracterizado por que dicho compuesto se selecciona del grupo que consiste en los compuestos representados por las estructuras del grupo de fórmulas (2); y sales farmacéuticamente aceptables de estos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462062597P | 2014-10-10 | 2014-10-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR102246A1 true AR102246A1 (es) | 2017-02-15 |
Family
ID=55652429
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP150103294A AR102246A1 (es) | 2014-10-10 | 2015-10-13 | Compuestos aromáticos sustituidos y composiciones farmacéuticas para la prevención y tratamiento de osteoporosis, usos |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US20180228750A1 (es) |
| EP (1) | EP3203999B1 (es) |
| JP (1) | JP6700639B2 (es) |
| KR (1) | KR20170066476A (es) |
| CN (1) | CN106999456B (es) |
| AR (1) | AR102246A1 (es) |
| AU (1) | AU2015330645B2 (es) |
| BR (1) | BR112017007426A2 (es) |
| CA (1) | CA2963354A1 (es) |
| DK (1) | DK3203999T3 (es) |
| ES (1) | ES2785317T3 (es) |
| IL (1) | IL251404B (es) |
| MX (1) | MX376873B (es) |
| MY (1) | MY194308A (es) |
| PH (1) | PH12017500638A1 (es) |
| PL (1) | PL3203999T3 (es) |
| PT (1) | PT3203999T (es) |
| RU (1) | RU2709205C2 (es) |
| SG (1) | SG11201702868VA (es) |
| TW (1) | TWI699200B (es) |
| UY (1) | UY36356A (es) |
| WO (1) | WO2016054728A1 (es) |
| ZA (1) | ZA201702639B (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3204000B1 (en) * | 2014-10-10 | 2020-01-08 | Liminal Biosciences Limited | Phenylketone carboxylate compounds and pharmaceutical compositions for the prevention and treatment of osteoporosis |
| RU2728782C2 (ru) * | 2014-11-12 | 2020-07-31 | Лиминал Байосайенсиз Лимитед | Замещенные ароматические соединения и фармацевтические композиции для ауторепарации и регенерации ткани |
| KR20180006881A (ko) | 2015-03-09 | 2018-01-19 | 인테크린 테라퓨틱스, 아이엔씨. | 비알코올성 지방간 질환 및/또는 지방이영양증의 치료 방법 |
| WO2018035449A1 (en) * | 2016-08-18 | 2018-02-22 | Intekrin Therapeutics, Inc. | Pparϒ agonist for treatment of bone disorders |
| AU2018249822A1 (en) | 2017-04-03 | 2019-10-31 | Coherus Biosciences Inc. | PPArgamma agonist for treatment of progressive supranuclear palsy |
| CN116568291A (zh) * | 2020-10-06 | 2023-08-08 | 殷格纽制药有限公司 | 取代的芳香族化合物及其药物组合物 |
| CA3237127A1 (en) * | 2021-11-17 | 2023-05-25 | Sanyasi R. Kalidindi | Withania somnifera and asparagus racemosus in treating post-menopausal conditions |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006124662A1 (en) * | 2005-05-13 | 2006-11-23 | Synta Pharmaceuticals Corp. | Il-12 modulatory compounds |
| ES2441800T3 (es) * | 2009-05-04 | 2014-02-06 | Prometic Biosciences Inc. | Sales de ácido 3-pentilfenilacético y usos farmacéuticos de las mismas |
| DK2427416T3 (en) * | 2009-05-04 | 2016-06-13 | Prometic Pharma Smt Ltd | Substituted aromatic compounds, and pharmaceutical uses thereof |
| AU2011320057B2 (en) * | 2010-10-27 | 2016-02-25 | Liminal Biosciences Limited | Phenylketone carboxylate compounds and pharmaceutical uses thereof |
| PH12013500766B1 (en) * | 2010-10-27 | 2017-09-29 | Prometic Pharma Smt Ltd | Compounds and compositions for the treatment of cancer |
| TWI689490B (zh) * | 2013-03-15 | 2020-04-01 | 英商邊緣生物科技有限公司 | 用於治療纖維化之經取代之芳族化合物及相關方法 |
| TWI742541B (zh) * | 2013-03-15 | 2021-10-11 | 英商邊緣生物科技有限公司 | 用於治療肺纖維化、肝纖維化、皮膚纖維化及心臟纖維化之經取代之芳族化合物 |
| EP3204000B1 (en) * | 2014-10-10 | 2020-01-08 | Liminal Biosciences Limited | Phenylketone carboxylate compounds and pharmaceutical compositions for the prevention and treatment of osteoporosis |
-
2015
- 2015-10-08 MY MYPI2017000520A patent/MY194308A/en unknown
- 2015-10-08 MX MX2017004733A patent/MX376873B/es active IP Right Grant
- 2015-10-08 BR BR112017007426-5A patent/BR112017007426A2/pt not_active Application Discontinuation
- 2015-10-08 SG SG11201702868VA patent/SG11201702868VA/en unknown
- 2015-10-08 PL PL15849675T patent/PL3203999T3/pl unknown
- 2015-10-08 JP JP2017518905A patent/JP6700639B2/ja not_active Expired - Fee Related
- 2015-10-08 TW TW104133254A patent/TWI699200B/zh not_active IP Right Cessation
- 2015-10-08 WO PCT/CA2015/000540 patent/WO2016054728A1/en not_active Ceased
- 2015-10-08 KR KR1020177011332A patent/KR20170066476A/ko not_active Ceased
- 2015-10-08 CA CA2963354A patent/CA2963354A1/en not_active Abandoned
- 2015-10-08 US US15/516,643 patent/US20180228750A1/en not_active Abandoned
- 2015-10-08 DK DK15849675.2T patent/DK3203999T3/da active
- 2015-10-08 EP EP15849675.2A patent/EP3203999B1/en active Active
- 2015-10-08 PT PT158496752T patent/PT3203999T/pt unknown
- 2015-10-08 AU AU2015330645A patent/AU2015330645B2/en not_active Ceased
- 2015-10-08 ES ES15849675T patent/ES2785317T3/es active Active
- 2015-10-08 CN CN201580058623.7A patent/CN106999456B/zh not_active Expired - Fee Related
- 2015-10-08 RU RU2017116178A patent/RU2709205C2/ru active
- 2015-10-13 UY UY0001036356A patent/UY36356A/es not_active Application Discontinuation
- 2015-10-13 AR ARP150103294A patent/AR102246A1/es unknown
-
2017
- 2017-03-27 IL IL251404A patent/IL251404B/en active IP Right Grant
- 2017-04-06 PH PH12017500638A patent/PH12017500638A1/en unknown
- 2017-04-12 ZA ZA2017/02639A patent/ZA201702639B/en unknown
-
2020
- 2020-04-09 US US16/844,813 patent/US11185521B2/en not_active Expired - Fee Related
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |