[go: up one dir, main page]

AR101750A1 - SOLID FORM OF (1-CYAN-CYCLOPROPIL) AMID OF ACID (2S, 4R) -4- [4- (1-METHYL-1H-PIRAZOL-4-IL) -2-TRIFLUOROMETIL-BENCENOSULFONIL] -1- (1- TRIFLUOROMETIL-CICLOPROPANOCARBONIL) PIRROLIDIN-2-CARBOXÍLICO - Google Patents

SOLID FORM OF (1-CYAN-CYCLOPROPIL) AMID OF ACID (2S, 4R) -4- [4- (1-METHYL-1H-PIRAZOL-4-IL) -2-TRIFLUOROMETIL-BENCENOSULFONIL] -1- (1- TRIFLUOROMETIL-CICLOPROPANOCARBONIL) PIRROLIDIN-2-CARBOXÍLICO

Info

Publication number
AR101750A1
AR101750A1 ARP150102816A ARP150102816A AR101750A1 AR 101750 A1 AR101750 A1 AR 101750A1 AR P150102816 A ARP150102816 A AR P150102816A AR P150102816 A ARP150102816 A AR P150102816A AR 101750 A1 AR101750 A1 AR 101750A1
Authority
AR
Argentina
Prior art keywords
trifluorometil
methyl
acid
solid form
ciclopropanocarbonil
Prior art date
Application number
ARP150102816A
Other languages
Spanish (es)
Inventor
Thrse Gustaaf De Paepe Anne
Grassmann Olaf
Cueni Philipp
Bartels Bjoern
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR101750A1 publication Critical patent/AR101750A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Reivindicación 1: Forma sólida de (1-ciano-ciclopropil)-amida de ácido (2S,4R)-4-[4-(1-metil-1H-pirazol-4-il)-2-trifluorometil-bencenosulfonil]-1-(1-trifluorometil-ciclopropanocarbonil)-pirrolidin-2-carboxílico, caracterizada por un patrón de difracción de rayos X de los polvos obtenido con una radiación Ka de Cu que presentaba picos característicos expresados en grados 2q en aproximadamente 8,7, 15,5, 17,5, 19,2 y 20,5.Claim 1: Solid form of (1-cyano-cyclopropyl) -amide acid (2S, 4R) -4- [4- (1-methyl-1 H -pyrazol-4-yl) -2-trifluoromethyl-benzenesulfonyl] -1 - (1-Trifluoromethyl-cyclopropanecarbonyl) -pyrrolidin-2-carboxylic acid, characterized by an X-ray diffraction pattern of the powders obtained with a Cu Ka radiation that had characteristic peaks expressed in 2q degrees at approximately 8.7, 15, 5, 17.5, 19.2 and 20.5.

ARP150102816A 2014-09-05 2015-09-03 SOLID FORM OF (1-CYAN-CYCLOPROPIL) AMID OF ACID (2S, 4R) -4- [4- (1-METHYL-1H-PIRAZOL-4-IL) -2-TRIFLUOROMETIL-BENCENOSULFONIL] -1- (1- TRIFLUOROMETIL-CICLOPROPANOCARBONIL) PIRROLIDIN-2-CARBOXÍLICO AR101750A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP14183700 2014-09-05

Publications (1)

Publication Number Publication Date
AR101750A1 true AR101750A1 (en) 2017-01-11

Family

ID=51483334

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP150102816A AR101750A1 (en) 2014-09-05 2015-09-03 SOLID FORM OF (1-CYAN-CYCLOPROPIL) AMID OF ACID (2S, 4R) -4- [4- (1-METHYL-1H-PIRAZOL-4-IL) -2-TRIFLUOROMETIL-BENCENOSULFONIL] -1- (1- TRIFLUOROMETIL-CICLOPROPANOCARBONIL) PIRROLIDIN-2-CARBOXÍLICO

Country Status (3)

Country Link
AR (1) AR101750A1 (en)
TW (1) TW201625593A (en)
WO (1) WO2016034602A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI846731B (en) * 2018-09-18 2024-07-01 瑞士商赫孚孟拉羅股份公司 Use of a cathepsin s inhibitor against the formation of anti-drug antibodies

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA106748C2 (en) * 2009-04-20 2014-10-10 Ф. Хоффманн-Ля Рош Аг Proline derivatives as cathepsin inhibitors
MY167569A (en) * 2011-11-11 2018-09-20 Hoffmann La Roche Process for the preparation of 1-acyl-4-phenylsulfonylprolinamide derivatives and new intermediates

Also Published As

Publication number Publication date
WO2016034602A1 (en) 2016-03-10
TW201625593A (en) 2016-07-16

Similar Documents

Publication Publication Date Title
CU24462B1 (en) DERIVATIVES OF PHENYLTRIAZOLE SUBSTITUTED WITH HYDROXYALKYL
MY191581A (en) Anti-pd-1 antibodies
MX2017004539A (en) Heterophasic polypropylene with improved impact strength/stiffness balance, improved powder flowability, reduced emissions and low shrinkage.
CR20200274A (en) Fungicidal oxadiazoles
WO2016094837A3 (en) Anti-c10orf54 antibodies and uses thereof
MX2019009842A (en) Solid composition comprising amorphous sofosbuvir.
CL2016001587A1 (en) Derivative based on 1,2-naphthoquinone and method of preparation thereof.
MY193650A (en) Extracellular matrix compositions
SG11201709426XA (en) Resin composition, film produced by using the resincomposition, and multilayer structure
GB201602974D0 (en) Engineered cells & methods (1)
WO2016089886A3 (en) Methods for treating dry eye disease by administering an il-6r antagonist
EA201692154A1 (en) OVERALL FALLING FILM
JP2015173751A5 (en)
JP2015016294A5 (en)
CL2018001715A1 (en) CFR regulators and methods for use
EP3588637A4 (en) Resin for energy device electrode, composition for forming energy device electrode, energy device electrode, and energy device
MX2017006712A (en) Matrix metalloproteinase production inhibitor.
MX2016013439A (en) Solid forms of a pharmaceutically active compound.
CL2018001716A1 (en) CFR regulators and methods for use
AR101750A1 (en) SOLID FORM OF (1-CYAN-CYCLOPROPIL) AMID OF ACID (2S, 4R) -4- [4- (1-METHYL-1H-PIRAZOL-4-IL) -2-TRIFLUOROMETIL-BENCENOSULFONIL] -1- (1- TRIFLUOROMETIL-CICLOPROPANOCARBONIL) PIRROLIDIN-2-CARBOXÍLICO
AU2016345054A8 (en) Apparatus for storing organic material
WO2017061544A8 (en) Radiation-damage-compensation-circuit and soi-mosfet
MX2016010662A (en) Compounds for improving cognition and social behavior in humans having neurological disorders.
JP2015226493A5 (en)
IT201700003232A1 (en) "IMPROVED PRESS BRAKE"

Legal Events

Date Code Title Description
FB Suspension of granting procedure