AR100846A1 - FORMULACIONES INTRAVAGINALES QUE COMPRENDEN GnRH - Google Patents
FORMULACIONES INTRAVAGINALES QUE COMPRENDEN GnRHInfo
- Publication number
- AR100846A1 AR100846A1 ARP150101903A ARP150101903A AR100846A1 AR 100846 A1 AR100846 A1 AR 100846A1 AR P150101903 A ARP150101903 A AR P150101903A AR P150101903 A ARP150101903 A AR P150101903A AR 100846 A1 AR100846 A1 AR 100846A1
- Authority
- AR
- Argentina
- Prior art keywords
- acid
- formulation
- intravaginal
- gnrh
- amount
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 6
- NMJREATYWWNIKX-UHFFFAOYSA-N GnRH Chemical compound C1CCC(C(=O)NCC(N)=O)N1C(=O)C(CC(C)C)NC(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)CNC(=O)C(NC(=O)C(CO)NC(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C(CC=1NC=NC=1)NC(=O)C1NC(=O)CC1)CC1=CC=C(O)C=C1 NMJREATYWWNIKX-UHFFFAOYSA-N 0.000 title abstract 3
- 101000857870 Squalus acanthias Gonadoliberin Proteins 0.000 title abstract 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 abstract 6
- 238000009472 formulation Methods 0.000 abstract 5
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 abstract 2
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 abstract 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 abstract 2
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 abstract 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 abstract 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 abstract 1
- 241000282849 Ruminantia Species 0.000 abstract 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 abstract 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 abstract 1
- 235000010323 ascorbic acid Nutrition 0.000 abstract 1
- 229960005070 ascorbic acid Drugs 0.000 abstract 1
- 239000011668 ascorbic acid Substances 0.000 abstract 1
- 235000003704 aspartic acid Nutrition 0.000 abstract 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 abstract 1
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 abstract 1
- KCIDZIIHRGYJAE-YGFYJFDDSA-L dipotassium;[(2r,3r,4s,5r,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] phosphate Chemical compound [K+].[K+].OC[C@H]1O[C@H](OP([O-])([O-])=O)[C@H](O)[C@@H](O)[C@H]1O KCIDZIIHRGYJAE-YGFYJFDDSA-L 0.000 abstract 1
- 229940009662 edetate Drugs 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 235000014655 lactic acid Nutrition 0.000 abstract 1
- 239000004310 lactic acid Substances 0.000 abstract 1
- 238000002844 melting Methods 0.000 abstract 1
- 230000008018 melting Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000016087 ovulation Effects 0.000 abstract 1
- 239000011975 tartaric acid Substances 0.000 abstract 1
- 235000002906 tartaric acid Nutrition 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Reproductive Health (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Gynecology & Obstetrics (AREA)
- Gastroenterology & Hepatology (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Pregnancy & Childbirth (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Abstract
Formulación intravaginal, que comprende un ácido carboxílico en una cantidad del 10 - 20% peso/peso de dicha formulación, una base oleaginosa, que tiene una temperatura de fusión entre 30ºC y 38ºC, GnRH o uno de sus análogos, en una cantidad equivalente a la cantidad de GnRH de entre 10 mg y 600 mg. También se proporciona un método para inducir ovulación en un rumiante usando la formulación. Reivindicación 15: La formulación intravaginal de una cualquiera de las reivindicaciones 1 - 14, caracterizada porque el ácido carboxílico está seleccionado entre el grupo que consiste en ácido cítrico, ácido succínico, ácido tartárico, ácido glicólico, ácido ascórbico, ácido láctico, ácido aspártico, edetato de dipotasio o una de sus combinaciones. Reivindicación 16: La formulación intravaginal de la reivindicación 15, caracterizada porque dicho ácido carboxílico es ácido cítrico.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462012523P | 2014-06-16 | 2014-06-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR100846A1 true AR100846A1 (es) | 2016-11-02 |
Family
ID=53773489
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP150101903A AR100846A1 (es) | 2014-06-16 | 2015-06-15 | FORMULACIONES INTRAVAGINALES QUE COMPRENDEN GnRH |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20170143786A1 (es) |
| EP (1) | EP3154519A1 (es) |
| JP (1) | JP2017519769A (es) |
| CN (1) | CN106456705A (es) |
| AR (1) | AR100846A1 (es) |
| AU (1) | AU2015277613A1 (es) |
| BR (1) | BR112016028875A2 (es) |
| CA (1) | CA2951532A1 (es) |
| CL (1) | CL2016003220A1 (es) |
| IL (1) | IL249121A0 (es) |
| MX (1) | MX2016016768A (es) |
| RU (1) | RU2016146994A (es) |
| UY (1) | UY36168A (es) |
| WO (1) | WO2015195333A1 (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11376220B2 (en) * | 2017-06-30 | 2022-07-05 | Therio, LLC | Single-injection methods and formulations to induce and control multiple ovarian follicles in bovine, caprine, ovine, camelid and other female animals |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4211769A (en) * | 1977-08-24 | 1980-07-08 | Takeda Chemical Industries, Ltd. | Preparations for vaginal administration |
| US5985320A (en) * | 1996-03-04 | 1999-11-16 | The Penn State Research Foundation | Materials and methods for enhancing cellular internalization |
| CN101692985A (zh) * | 2009-09-29 | 2010-04-14 | 浙江大学 | 一种诱导奶牛定时排卵进行人工授精的方法 |
| CN101779988A (zh) * | 2010-02-03 | 2010-07-21 | 李树静 | 一种青年牛高强度重复超数排卵的方法 |
-
2015
- 2015-06-03 AU AU2015277613A patent/AU2015277613A1/en not_active Abandoned
- 2015-06-03 RU RU2016146994A patent/RU2016146994A/ru unknown
- 2015-06-03 MX MX2016016768A patent/MX2016016768A/es unknown
- 2015-06-03 CN CN201580032022.9A patent/CN106456705A/zh active Pending
- 2015-06-03 EP EP15745266.5A patent/EP3154519A1/en not_active Withdrawn
- 2015-06-03 JP JP2016573959A patent/JP2017519769A/ja active Pending
- 2015-06-03 CA CA2951532A patent/CA2951532A1/en not_active Abandoned
- 2015-06-03 US US15/318,851 patent/US20170143786A1/en not_active Abandoned
- 2015-06-03 BR BR112016028875A patent/BR112016028875A2/pt not_active Application Discontinuation
- 2015-06-03 WO PCT/US2015/033951 patent/WO2015195333A1/en not_active Ceased
- 2015-06-15 UY UY0001036168A patent/UY36168A/es not_active Application Discontinuation
- 2015-06-15 AR ARP150101903A patent/AR100846A1/es unknown
-
2016
- 2016-11-22 IL IL249121A patent/IL249121A0/en unknown
- 2016-12-15 CL CL2016003220A patent/CL2016003220A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2951532A1 (en) | 2015-12-23 |
| EP3154519A1 (en) | 2017-04-19 |
| MX2016016768A (es) | 2017-04-04 |
| BR112016028875A2 (pt) | 2017-08-22 |
| US20170143786A1 (en) | 2017-05-25 |
| RU2016146994A3 (es) | 2018-07-16 |
| CL2016003220A1 (es) | 2017-06-02 |
| IL249121A0 (en) | 2017-01-31 |
| AU2015277613A1 (en) | 2016-12-08 |
| UY36168A (es) | 2016-01-29 |
| WO2015195333A1 (en) | 2015-12-23 |
| CN106456705A (zh) | 2017-02-22 |
| JP2017519769A (ja) | 2017-07-20 |
| RU2016146994A (ru) | 2018-07-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |