AR100002A1 - Formulación inmunosupresora - Google Patents
Formulación inmunosupresoraInfo
- Publication number
- AR100002A1 AR100002A1 ARP150101084A ARP150101084A AR100002A1 AR 100002 A1 AR100002 A1 AR 100002A1 AR P150101084 A ARP150101084 A AR P150101084A AR P150101084 A ARP150101084 A AR P150101084A AR 100002 A1 AR100002 A1 AR 100002A1
- Authority
- AR
- Argentina
- Prior art keywords
- dosage form
- pharmaceutical excipient
- protective agent
- iii
- moisture protective
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 4
- 238000009472 formulation Methods 0.000 title 1
- 239000003018 immunosuppressive agent Substances 0.000 title 1
- 239000002552 dosage form Substances 0.000 abstract 8
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 5
- 229940124531 pharmaceutical excipient Drugs 0.000 abstract 5
- 239000003223 protective agent Substances 0.000 abstract 4
- KIHYPELVXPAIDH-HNSNBQBZSA-N 1-[[4-[(e)-n-[[4-cyclohexyl-3-(trifluoromethyl)phenyl]methoxy]-c-methylcarbonimidoyl]-2-ethylphenyl]methyl]azetidine-3-carboxylic acid Chemical compound CCC1=CC(C(\C)=N\OCC=2C=C(C(C3CCCCC3)=CC=2)C(F)(F)F)=CC=C1CN1CC(C(O)=O)C1 KIHYPELVXPAIDH-HNSNBQBZSA-N 0.000 abstract 3
- 229950005693 siponimod Drugs 0.000 abstract 3
- 239000011248 coating agent Substances 0.000 abstract 2
- 238000000576 coating method Methods 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- OKMWKBLSFKFYGZ-UHFFFAOYSA-N 1-behenoylglycerol Chemical compound CCCCCCCCCCCCCCCCCCCCCC(=O)OCC(O)CO OKMWKBLSFKFYGZ-UHFFFAOYSA-N 0.000 abstract 1
- 239000004359 castor oil Substances 0.000 abstract 1
- 235000019438 castor oil Nutrition 0.000 abstract 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 abstract 1
- 229940049654 glyceryl behenate Drugs 0.000 abstract 1
- 125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 abstract 1
- 239000008172 hydrogenated vegetable oil Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5089—Processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Reivindicación 1: Una forma de dosificación que puede obtenerse mediante un proceso que comprende los pasos i) proporcionar siponimod, ii) pre-mezclar el compuesto de la etapa i) con el agente protector de humedad y opcionalmente un excipiente farmacéutico, iii) combinar la mezcla de la etapa ii) con excipiente(s) farmacéutico(s), iv) procesar la mezcla de la etapa iii) para tener una forma de dosificación, v) opcionalmente, recubrir con una película a la forma de dosificación. Reivindicación 2: La forma de dosificación que contiene de 0,2 a 12% (p/p) de siponimod, de 1 a 8% (p/p) de agente protector de humedad y de 80 a 98,8% (p/p) de excipiente(s) farmacéutico(s). Reivindicación 7: La forma de dosificación de acuerdo con cualquiera de las reivindicaciones 1 a 6, en donde el agente protector de humedad se selecciona a partir de aceite vegetal hidrogenado, aceite de ricino, estearato de palmitol, palmitoestearato de glicerilo y behenato de glicerilo. Reivindicación 14: Procedimiento para producir una forma de dosificación que comprende las etapas de i) proporcionar siponimod, ii) pre-mezclar los compuestos de la etapa i) con el agente protector de humedad y opcionalmente un excipiente farmacéutico, iii) combinar la mezcla de la etapa ii) con excipiente(s) farmacéutico(s), iv) el procesamiento de la mezcla de la etapa iii) para tener una forma de dosificación, v) opcionalmente, recubrir con una película a la forma de dosificación.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461977806P | 2014-04-10 | 2014-04-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR100002A1 true AR100002A1 (es) | 2016-08-31 |
Family
ID=53525213
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP150101084A AR100002A1 (es) | 2014-04-10 | 2015-04-10 | Formulación inmunosupresora |
Country Status (23)
| Country | Link |
|---|---|
| US (5) | US20170027906A1 (es) |
| EP (1) | EP3129006B1 (es) |
| JP (2) | JP6679495B2 (es) |
| KR (1) | KR102466348B1 (es) |
| CN (1) | CN106163502B (es) |
| AR (1) | AR100002A1 (es) |
| AU (1) | AU2015246038C1 (es) |
| CA (1) | CA2942236C (es) |
| CL (1) | CL2016002560A1 (es) |
| DK (1) | DK3129006T3 (es) |
| EA (1) | EA201692043A1 (es) |
| ES (1) | ES2865451T3 (es) |
| HU (1) | HUE054245T2 (es) |
| IL (1) | IL247599B (es) |
| MX (1) | MX2016013236A (es) |
| PE (1) | PE20161385A1 (es) |
| PH (1) | PH12016501841A1 (es) |
| PL (1) | PL3129006T3 (es) |
| PT (1) | PT3129006T (es) |
| SG (1) | SG11201607354PA (es) |
| SI (1) | SI3129006T1 (es) |
| TW (1) | TW201622707A (es) |
| WO (1) | WO2015155711A1 (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20191842T1 (hr) | 2011-01-07 | 2019-12-27 | Novartis Ag | Formulacije imunosupresiva |
| PL3129006T3 (pl) * | 2014-04-10 | 2021-07-05 | Novartis Ag | Formulacja immunosupresanta |
| US11629124B2 (en) | 2017-03-09 | 2023-04-18 | Novartis Ag | Solid forms comprising an oxime ether compound, compositions and methods of use thereof |
| US11434200B2 (en) | 2017-03-09 | 2022-09-06 | Novartis Ag | Solid forms comprising an oxime ether compound and a coformer, compositions and methods of use thereof |
| AU2018341136A1 (en) * | 2017-09-27 | 2020-03-12 | Novartis Ag | Parenteral formulation comprising siponimod |
| AU2018341154A1 (en) | 2017-09-29 | 2020-03-12 | Novartis Ag | Dosing regimen of siponimod |
| AU2018343239A1 (en) | 2017-09-29 | 2020-03-12 | Novartis Ag | Dosing regimen of siponimod |
| US11673860B2 (en) | 2018-01-22 | 2023-06-13 | Teva Pharmaceuticals International Gmbh | Crystalline siponimod fumaric acid and polymorphs thereof |
| CN109908095A (zh) * | 2019-04-08 | 2019-06-21 | 肇庆学院 | 一种西尼莫德片剂及制备方法 |
| WO2021214717A1 (en) | 2020-04-23 | 2021-10-28 | Novartis Ag | Dosing regimen for the use of siponimod for the treatment of acute respiratory distress syndrome |
| CN113633632A (zh) * | 2021-09-09 | 2021-11-12 | 暨南大学附属第一医院（广州华侨医院） | siponimod在制备抗肿瘤转移药物中的应用 |
| EP4633611A1 (en) | 2022-12-12 | 2025-10-22 | Synthon B.V. | Pharmaceutical composition of siponimod |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2465492T3 (pl) * | 2007-10-12 | 2015-11-30 | Novartis Ag | Mieszaniny zawierające modulatory receptora 1-fosforanu sfingozyny (S1P) |
| JP5190815B2 (ja) | 2008-07-16 | 2013-04-24 | 日本電気株式会社 | Ｉｕ−ＵＰプロトコルのネゴシエーション結果情報の通知方法、プロトコル変換方法、通信ネットワークシステム、インターワーキング装置、ＩｕＵＰネゴシエーション結果情報取得装置及びコンピュータ読み取り可能な情報記録媒体 |
| CA2747437C (en) | 2008-12-18 | 2018-08-21 | Novartis Ag | Hemifumarate salt of 1-[4-[1-(4-cyclohexyl-3-trifluoromethyl-benzyloxyimino)-ethyl]-2-ethyl-benzyl]-a zetidine-3-carboxylic acid |
| CA2746764A1 (en) | 2008-12-18 | 2010-06-24 | Novartis Ag | New polymorphic form of 1- (4- { l- [ (e) -4-cyclohexyl--3-trifluoromethyl-benzyloxyimino] -ethyl) -2-ethyl-benzy l) -azetidine-3-carboxylic |
| KR101660555B1 (ko) * | 2008-12-22 | 2016-09-27 | 노파르티스 아게 | Ｓ１ｐ 수용체 효능제의 투여 요법 |
| CN101480374A (zh) * | 2009-01-20 | 2009-07-15 | 苏州中化药品工业有限公司 | 一种稳定的固体药物组合物 |
| HRP20191842T1 (hr) * | 2011-01-07 | 2019-12-27 | Novartis Ag | Formulacije imunosupresiva |
| WO2012095853A1 (en) * | 2011-01-10 | 2012-07-19 | Novartis Pharma Ag | Modified release formulations comprising sip receptor modulators |
| PL3129006T3 (pl) * | 2014-04-10 | 2021-07-05 | Novartis Ag | Formulacja immunosupresanta |
-
2015
- 2015-04-08 PL PL15735733T patent/PL3129006T3/pl unknown
- 2015-04-08 EA EA201692043A patent/EA201692043A1/ru unknown
- 2015-04-08 KR KR1020167027528A patent/KR102466348B1/ko active Active
- 2015-04-08 JP JP2016561629A patent/JP6679495B2/ja active Active
- 2015-04-08 EP EP15735733.6A patent/EP3129006B1/en active Active
- 2015-04-08 DK DK15735733.6T patent/DK3129006T3/da active
- 2015-04-08 AU AU2015246038A patent/AU2015246038C1/en active Active
- 2015-04-08 SI SI201531566T patent/SI3129006T1/sl unknown
- 2015-04-08 SG SG11201607354PA patent/SG11201607354PA/en unknown
- 2015-04-08 US US15/300,968 patent/US20170027906A1/en not_active Abandoned
- 2015-04-08 CA CA2942236A patent/CA2942236C/en active Active
- 2015-04-08 WO PCT/IB2015/052552 patent/WO2015155711A1/en not_active Ceased
- 2015-04-08 ES ES15735733T patent/ES2865451T3/es active Active
- 2015-04-08 PT PT157357336T patent/PT3129006T/pt unknown
- 2015-04-08 MX MX2016013236A patent/MX2016013236A/es unknown
- 2015-04-08 CN CN201580018811.7A patent/CN106163502B/zh active Active
- 2015-04-08 PE PE2016001740A patent/PE20161385A1/es not_active Application Discontinuation
- 2015-04-08 HU HUE15735733A patent/HUE054245T2/hu unknown
- 2015-04-09 TW TW104111464A patent/TW201622707A/zh unknown
- 2015-04-10 AR ARP150101084A patent/AR100002A1/es unknown
-
2016
- 2016-09-01 IL IL247599A patent/IL247599B/en active IP Right Grant
- 2016-09-20 PH PH12016501841A patent/PH12016501841A1/en unknown
- 2016-10-07 CL CL2016002560A patent/CL2016002560A1/es unknown
-
2018
- 2018-03-20 US US15/926,699 patent/US20180207128A1/en not_active Abandoned
-
2019
- 2019-03-21 US US16/360,696 patent/US20190328705A1/en not_active Abandoned
-
2020
- 2020-01-24 JP JP2020009871A patent/JP2020097591A/ja not_active Withdrawn
-
2021
- 2021-02-04 US US17/167,635 patent/US20210161860A1/en not_active Abandoned
-
2024
- 2024-03-14 US US18/605,259 patent/US20250073203A1/en active Pending
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