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AR109539A1 - Sitio de inserción orf70 de ehv - Google Patents

Sitio de inserción orf70 de ehv

Info

Publication number
AR109539A1
AR109539A1 ARP170102576A ARP170102576A AR109539A1 AR 109539 A1 AR109539 A1 AR 109539A1 AR P170102576 A ARP170102576 A AR P170102576A AR P170102576 A ARP170102576 A AR P170102576A AR 109539 A1 AR109539 A1 AR 109539A1
Authority
AR
Argentina
Prior art keywords
sequence
homologous
seq
interest
orf70
Prior art date
Application number
ARP170102576A
Other languages
English (en)
Inventor
Kristina REHMET
Andreas Gallei
Alice Mundt
Original Assignee
Boehringer Ingelheim Vetmedica Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Vetmedica Gmbh filed Critical Boehringer Ingelheim Vetmedica Gmbh
Publication of AR109539A1 publication Critical patent/AR109539A1/es

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552—Veterinary vaccine
    • A—HUMAN NECESSITIES
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
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    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16171—Demonstrated in vivo effect

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Abstract

Vacuna (de vector), y en especial, al sitio de inserción ORF70 de EHV (alfaherpesvirus equino 1). También casetes de expresión y vectores relacionados, que son adecuados para expresar genes de interés, en especial, secuencias que codifican un antígeno. Los vectores virales son útiles para producir una composición inmunógena o vacuna. Reivindicación 1: Un casete de expresión caracterizado porque comprende (i) al menos una secuencia de nucleótidos exógena de interés, preferentemente, un gen de interés, con mayor preferencia, una secuencia que codifica un antígeno, por lo cual dicha secuencia de nucleótidos de interés, preferentemente, un gen de interés, con mayor preferencia, una secuencia que codifica un antígeno, está ligada operativamente a una secuencia promotora, y (ii) al menos una región de flanqueo izquierda de ORF70 seleccionada del grupo que consiste en: SEQ ID Nº 13 y una secuencia 70%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% homóloga y/o idéntica de esta, SEQ ID Nº 15 y una secuencia 70%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% homóloga y/o idéntica de esta, SEQ ID Nº 17 y una secuencia 70%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% homóloga y/o idéntica de esta, y (iii) al menos una región de flanqueo derecha de ORF70 seleccionada del grupo que consiste en: SEQ ID Nº 14 y una secuencia 70%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% homóloga y/o idéntica de esta, SEQ ID Nº 16 y una secuencia 70%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% homóloga y/o idéntica de esta, SEQ ID Nº 18 y una secuencia 70%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% homóloga y/o idéntica de aquel.
ARP170102576A 2016-09-20 2017-09-18 Sitio de inserción orf70 de ehv AR109539A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP16189776 2016-09-20

Publications (1)

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AR109539A1 true AR109539A1 (es) 2018-12-19

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ARP170102576A AR109539A1 (es) 2016-09-20 2017-09-18 Sitio de inserción orf70 de ehv

Country Status (19)

Country Link
US (1) US10619169B2 (es)
EP (1) EP3515481A1 (es)
JP (2) JP6952112B2 (es)
KR (1) KR102618843B1 (es)
CN (1) CN109715204B (es)
AR (1) AR109539A1 (es)
AU (1) AU2017329669B2 (es)
BR (1) BR112019005516A2 (es)
CA (1) CA3036291A1 (es)
CL (1) CL2019000655A1 (es)
EA (1) EA201990711A1 (es)
MX (1) MX2019003161A (es)
MY (1) MY199743A (es)
NZ (1) NZ751014A (es)
PH (1) PH12019500557A1 (es)
SA (1) SA519401350B1 (es)
TW (1) TWI817933B (es)
UY (1) UY37406A (es)
WO (1) WO2018054837A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7187448B2 (ja) 2016-09-20 2022-12-12 ベーリンガー インゲルハイム フェトメディカ ゲーエムベーハー 新しいプロモーター
AR109539A1 (es) 2016-09-20 2018-12-19 Boehringer Ingelheim Vetmedica Gmbh Sitio de inserción orf70 de ehv
HUE064133T2 (hu) 2016-09-20 2024-03-28 Boehringer Ingelheim Vetmedica Gmbh Kutya adenovírus vektor
WO2018054822A1 (en) 2016-09-20 2018-03-29 Boehringer Ingelheim Vetmedica Gmbh New swine influenza vaccine
JP7346417B2 (ja) 2017-12-18 2023-09-19 インターベット インターナショナル ベー． フェー． ブタインフルエンザａウイルスワクチン
US20250249090A1 (en) 2020-11-13 2025-08-07 Boehringer Ingelheim Vetmedica Gmbh New feline herpes virus vaccine

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