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AR109528A1 - Mutaciones estabilizantes de trímeros de proteínas de la envoltura del vih - Google Patents

Mutaciones estabilizantes de trímeros de proteínas de la envoltura del vih

Info

Publication number
AR109528A1
AR109528A1 ARP170102536A ARP170102536A AR109528A1 AR 109528 A1 AR109528 A1 AR 109528A1 AR P170102536 A ARP170102536 A AR P170102536A AR P170102536 A ARP170102536 A AR P170102536A AR 109528 A1 AR109528 A1 AR 109528A1
Authority
AR
Argentina
Prior art keywords
hiv
envelope proteins
trimmers
hiv envelope
protein
Prior art date
Application number
ARP170102536A
Other languages
English (en)
Inventor
Johannes Petrus Maria Langedijk
Nika Mindy Strokappe
Daphn Truan
Lucy Rutten
Original Assignee
Janssen Vaccines & Prevention Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Vaccines & Prevention Bv filed Critical Janssen Vaccines & Prevention Bv
Publication of AR109528A1 publication Critical patent/AR109528A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/08—RNA viruses
    • C07K14/15—Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus human T-cell leukaemia-lymphoma virus
    • C07K14/155—Lentiviridae, e.g. human immunodeficiency virus [HIV], visna-maedi virus or equine infectious anaemia virus
    • C07K14/16—HIV-1 ; HIV-2
    • C07K14/162—HIV-1 ; HIV-2 env, e.g. gp160, gp110/120, gp41, V3, peptid T, CD4-Binding site
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/21—Retroviridae, e.g. equine infectious anemia virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/02—Recovery or purification

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Proteínas de la envoltura del virus de inmunodeficiencia humana (VIH) con mutaciones que estabilizan la forma trimérica de la proteína de la envoltura. Las proteínas de la envoltura del VIH tienen algunas sustituciones de aminoácidos en posiciones específicas en la secuencia de la proteína de la envoltura. Las proteínas de la envoltura del VIH que se describen en la presente tienen un porcentaje mejorado de la formación de trímeros y/o un rendimiento de trímeros mejorado en comparación con una proteína de la envoltura del VIH que no tiene una o más de las sustituciones de aminoácidos indicadas. También se proveen moléculas de ácido nucleico y vectores que codifican las proteínas de la envoltura del VIH, así como composiciones que contienen las proteínas de la envoltura del VIH, los ácidos nucleicos y los vectores.
ARP170102536A 2016-09-15 2017-09-14 Mutaciones estabilizantes de trímeros de proteínas de la envoltura del vih AR109528A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP16188866 2016-09-15

Publications (1)

Publication Number Publication Date
AR109528A1 true AR109528A1 (es) 2018-12-19

Family

ID=57017955

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP170102536A AR109528A1 (es) 2016-09-15 2017-09-14 Mutaciones estabilizantes de trímeros de proteínas de la envoltura del vih

Country Status (31)

Country Link
US (3) US10793607B2 (es)
EP (2) EP3512543B1 (es)
JP (2) JP7178344B2 (es)
KR (1) KR102513146B1 (es)
CN (1) CN109689091A (es)
AR (1) AR109528A1 (es)
AU (2) AU2017327672B2 (es)
BR (1) BR112019004593A2 (es)
CA (1) CA3036959A1 (es)
CY (1) CY1124518T1 (es)
DK (1) DK3512543T3 (es)
EA (1) EA201990715A1 (es)
ES (1) ES2824525T3 (es)
HR (1) HRP20201458T1 (es)
HU (1) HUE052008T2 (es)
IL (2) IL265186B (es)
LT (1) LT3512543T (es)
MA (1) MA46230B1 (es)
MD (1) MD3512543T2 (es)
MX (1) MX2019002938A (es)
MY (1) MY190534A (es)
PH (1) PH12019500280A1 (es)
PL (1) PL3512543T3 (es)
PT (1) PT3512543T (es)
RS (1) RS60919B1 (es)
SG (2) SG10202001956UA (es)
SI (1) SI3512543T1 (es)
SM (1) SMT202000548T1 (es)
TW (1) TWI742158B (es)
WO (1) WO2018050747A1 (es)
ZA (1) ZA201901597B (es)

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AU2017327672B2 (en) 2020-10-15
MY190534A (en) 2022-04-27
MA46230B1 (fr) 2020-10-28
JP2023011941A (ja) 2023-01-24
MX2019002938A (es) 2019-10-15
KR102513146B1 (ko) 2023-03-23
HRP20201458T1 (hr) 2020-12-11
HUE052008T2 (hu) 2021-04-28
LT3512543T (lt) 2020-11-10
US20200369731A1 (en) 2020-11-26
ES2824525T3 (es) 2021-05-12
TWI742158B (zh) 2021-10-11
NZ750773A (en) 2021-02-26
SI3512543T1 (sl) 2020-10-30
IL265186A (en) 2019-05-30
US20180072777A1 (en) 2018-03-15
AU2017327672A1 (en) 2019-02-28
CN109689091A (zh) 2019-04-26
ZA201901597B (en) 2022-12-21
US10793607B2 (en) 2020-10-06
AU2020267278B2 (en) 2023-07-20
JP7178344B2 (ja) 2022-11-25
SG11201901206SA (en) 2019-04-29
DK3512543T3 (da) 2020-10-12
KR20190050786A (ko) 2019-05-13
US11365222B2 (en) 2022-06-21
WO2018050747A1 (en) 2018-03-22
TW201819401A (zh) 2018-06-01
IL265186B (en) 2022-09-01
IL294832A (en) 2022-09-01
US11820796B2 (en) 2023-11-21
MA46230A (fr) 2019-07-24
JP2019534690A (ja) 2019-12-05
PT3512543T (pt) 2020-10-13
MD3512543T2 (ro) 2020-11-30
AU2020267278A1 (en) 2020-12-10
BR112019004593A2 (pt) 2019-07-02
EP3512543B1 (en) 2020-07-22
CY1124518T1 (el) 2022-03-24
EP3512543A1 (en) 2019-07-24
RS60919B1 (sr) 2020-11-30
EP3747463A1 (en) 2020-12-09
PL3512543T3 (pl) 2021-01-11
PH12019500280A1 (en) 2019-10-28
SMT202000548T1 (it) 2020-11-10
US20220315627A1 (en) 2022-10-06
EA201990715A1 (ru) 2019-08-30
SG10202001956UA (en) 2020-04-29
CA3036959A1 (en) 2018-03-22

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