AR109079A1 - Formas cristalinas de 4-ciano-n-(2-(4,4-dimetilciclohex-1-en-1-il)-6-(2,2,6,6-tetrametiltetrahidro-2h-piran-4-il)piridin-3-il)1h-imidazol-2-carboxamida - Google Patents
Formas cristalinas de 4-ciano-n-(2-(4,4-dimetilciclohex-1-en-1-il)-6-(2,2,6,6-tetrametiltetrahidro-2h-piran-4-il)piridin-3-il)1h-imidazol-2-carboxamidaInfo
- Publication number
- AR109079A1 AR109079A1 ARP170101991A ARP170101991A AR109079A1 AR 109079 A1 AR109079 A1 AR 109079A1 AR P170101991 A ARP170101991 A AR P170101991A AR P170101991 A ARP170101991 A AR P170101991A AR 109079 A1 AR109079 A1 AR 109079A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- AIDS & HIV (AREA)
- Oncology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Liquid Crystal Substances (AREA)
- Pyrane Compounds (AREA)
Abstract
Reivindicación 1: Una forma cristalina de 4-ciano-N-[2-(4,4-dimetilciclohex-1-en-1-il)-6-(2,2,6,6-tetrametiltetrahidro-2H-piran-4-il)piridin-3-il]-1H-imidazol-2-carboxamida (compuesto A) de fórmula (1), en donde la forma cristalina se selecciona del grupo que consiste en: la forma I del compuesto A, que produce un patrón de difracción de polvo de rayos X que comprende picos a 6,1, 9,2, 9,4, 12,7, 15,1, 15,7, y 18,4 grados 2q ± 0,2 grados 2q; la forma II del compuesto A, que produce un patrón de difracción de polvo de rayos X que comprende picos a 6,3, 7,3, 11,5, 17,0 y 18,3 grados 2q ± 0,2 grados 2q; la forma IIA del compuesto A, que produce un patrón de difracción de polvo de rayos X que comprende picos a 6,4, 14,1, 14,6, 17,1, 18,3, 18,9, 19,3 y 23,0 grados 2q ± 0,2 grados 2q; la forma IIB del compuesto A, que produce un patrón de difracción de polvo de rayos X que comprende picos a 6,3 y 18,9 grados 2q ± 0,2 grados 2q; la forma III del compuesto A, que produce un patrón de difracción de polvo de rayos X que comprende picos a 4,6, 6,3, 6,8, 9,1, 17,1, y 28,5 grados 2q ± 0,2 grados 2q; la forma IV del compuesto A, que produce un patrón de difracción de polvo de rayos X que comprende picos a 6,3, 6,6, 6,9, 7,3, 11,7, 17,1 y 18,3 grados 2q ± 0,2 grados 2q; la forma V del compuesto A, que produce un patrón de difracción de polvo de rayos X que comprende picos a 6,3, 7,4, 11,5, 11,7, 17,0, 18,3 y 23,0 grados 2q ± 0,2 grados 2q; y la forma VI del compuesto A, que produce un patrón de difracción de polvo de rayos X que comprende picos a 5,7, 10,8, 11,4 y 17,1 grados 2q ± 0,2 grados 2q.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662363622P | 2016-07-18 | 2016-07-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR109079A1 true AR109079A1 (es) | 2018-10-24 |
Family
ID=59631847
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP170101991A AR109079A1 (es) | 2016-07-18 | 2017-07-17 | Formas cristalinas de 4-ciano-n-(2-(4,4-dimetilciclohex-1-en-1-il)-6-(2,2,6,6-tetrametiltetrahidro-2h-piran-4-il)piridin-3-il)1h-imidazol-2-carboxamida |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US10314821B2 (es) |
| EP (1) | EP3484872B1 (es) |
| JP (1) | JP2019521159A (es) |
| KR (1) | KR20190026910A (es) |
| CN (1) | CN109952296A (es) |
| AR (1) | AR109079A1 (es) |
| AU (1) | AU2017299506B2 (es) |
| BR (1) | BR112019000982A2 (es) |
| CA (1) | CA3031230A1 (es) |
| EA (1) | EA201990320A1 (es) |
| ES (1) | ES2935647T3 (es) |
| MA (1) | MA45685A (es) |
| MX (2) | MX384614B (es) |
| TW (1) | TWI752980B (es) |
| UY (1) | UY37338A (es) |
| WO (1) | WO2018017444A1 (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2023548384A (ja) * | 2020-10-30 | 2023-11-16 | アテネックス アールアンドディ エルエルシー | Ｈｍ３０１８１メシル酸塩の多形 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO3240B1 (ar) * | 2007-10-17 | 2018-03-08 | Janssen Pharmaceutica Nv | c-fms مثبطات كيناز |
| EP2215482A2 (en) * | 2007-10-31 | 2010-08-11 | Janssen Pharmaceutica N.V. | Biomarker for assessing response to fms treatment |
| JOP20180012A1 (ar) * | 2012-08-07 | 2019-01-30 | Janssen Pharmaceutica Nv | عملية السلفنة باستخدام نونافلوروبوتانيسولفونيل فلوريد |
| WO2014151253A1 (en) | 2013-03-15 | 2014-09-25 | Janssen Pharmaceutica Nv | 4-cyano-n-(2-(4,4-dimethylcyclohex-1-en-1-yl)-6-(2,2,6,6-tetramethyltetrahydro-2h-pyran-4-yl)pyridin-3-yl)-1h-imidazole-2-carboxamide for the treatment of hodgkin's lymphoma |
| US9611259B2 (en) * | 2013-03-15 | 2017-04-04 | Janssen Pharmaceutica Nv | Substituted pyridine derivatives useful as C-FMS kinase inhibitors |
-
2017
- 2017-07-14 TW TW106123583A patent/TWI752980B/zh not_active IP Right Cessation
- 2017-07-17 CN CN201780057364.5A patent/CN109952296A/zh active Pending
- 2017-07-17 CA CA3031230A patent/CA3031230A1/en active Pending
- 2017-07-17 EP EP17752511.0A patent/EP3484872B1/en active Active
- 2017-07-17 US US15/651,385 patent/US10314821B2/en active Active
- 2017-07-17 EA EA201990320A patent/EA201990320A1/ru unknown
- 2017-07-17 MX MX2019000749A patent/MX384614B/es unknown
- 2017-07-17 AR ARP170101991A patent/AR109079A1/es not_active Application Discontinuation
- 2017-07-17 ES ES17752511T patent/ES2935647T3/es active Active
- 2017-07-17 KR KR1020197004327A patent/KR20190026910A/ko not_active Ceased
- 2017-07-17 BR BR112019000982-5A patent/BR112019000982A2/pt not_active Application Discontinuation
- 2017-07-17 WO PCT/US2017/042310 patent/WO2018017444A1/en not_active Ceased
- 2017-07-17 AU AU2017299506A patent/AU2017299506B2/en not_active Ceased
- 2017-07-17 MA MA045685A patent/MA45685A/fr unknown
- 2017-07-17 JP JP2019502219A patent/JP2019521159A/ja active Pending
- 2017-07-19 UY UY0001037338A patent/UY37338A/es unknown
-
2019
- 2019-01-17 MX MX2021006739A patent/MX2021006739A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2017299506B2 (en) | 2021-08-05 |
| ES2935647T3 (es) | 2023-03-08 |
| EP3484872B1 (en) | 2022-11-30 |
| TW201808941A (zh) | 2018-03-16 |
| MX2021006739A (es) | 2021-07-15 |
| CN109952296A (zh) | 2019-06-28 |
| EA201990320A1 (ru) | 2019-06-28 |
| US10314821B2 (en) | 2019-06-11 |
| TWI752980B (zh) | 2022-01-21 |
| AU2017299506A1 (en) | 2019-02-07 |
| MX2019000749A (es) | 2019-08-29 |
| CA3031230A1 (en) | 2018-01-25 |
| EP3484872A1 (en) | 2019-05-22 |
| BR112019000982A2 (pt) | 2019-05-14 |
| WO2018017444A1 (en) | 2018-01-25 |
| UY37338A (es) | 2018-01-31 |
| MX384614B (es) | 2025-03-14 |
| JP2019521159A (ja) | 2019-07-25 |
| KR20190026910A (ko) | 2019-03-13 |
| MA45685A (fr) | 2019-05-22 |
| US20180133197A1 (en) | 2018-05-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |