AR107927A1 - Compuestos de pirrolidina, sal farmacéuticamente aceptable del mismo, composición farmacéutica que lo comprende y su uso para la fabricación de un medicamento - Google Patents
Compuestos de pirrolidina, sal farmacéuticamente aceptable del mismo, composición farmacéutica que lo comprende y su uso para la fabricación de un medicamentoInfo
- Publication number
- AR107927A1 AR107927A1 ARP170100685A ARP170100685A AR107927A1 AR 107927 A1 AR107927 A1 AR 107927A1 AR P170100685 A ARP170100685 A AR P170100685A AR P170100685 A ARP170100685 A AR P170100685A AR 107927 A1 AR107927 A1 AR 107927A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- hydrogen
- compounds
- pharmaceutically acceptable
- acceptable salt
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Un compuesto de pirrolidina que tiene de la fórmula (1) en donde, o bien R¹ y R² cada uno independientemente representan hidrógeno o un grupo -O-CR⁵R⁶-CR⁷R⁸-O(alquilo C₁₋₂), en donde R⁵, R⁶, R⁷, y R⁸, cada uno independientemente representan hidrógeno o metilo; con la condición de que R¹ y R² no pueden representar ambos hidrógeno; o R² representa hidrógeno y R¹ representa: (i) un grupo seleccionado entre: los compuestos del grupo de fórmulas (2) o (ii) un grupo seleccionado entre: los compuestos del grupo de fórmulas (3) o (iii) un grupo seleccionado entre: los compuestos del grupo de fórmulas (4); o R² representa hidrógeno y R¹ representa el resto de fórmula (5); o uno de R¹ y R² representa un grupo -O(CH₂)₂OMe y el otro representa -O(CH₂)₂F; y R³ representa hidrógeno o flúor; con la condición de que cuando tanto R¹ como R² representan un grupo distinto de hidrógeno entonces R³ representa hidrógeno; siempre y cuando el compuesto no sea ácido (S)-4-((S)-3-fluoro-3-(2-(5,6,7,8-tetrahidro-1,8-naftiridin-2-il)etil)pirrolidin-1-il)-3-(3-(2-metoxietoxi)fenil)butanoico; o una sal farmacéuticamente aceptable del mismo, que tiene una actividad antagonista de la integrina aᵛb₆. Composición farmacéutica que incluye un compuesto de la fórmula (1) o una sal farmacéuticamente aceptable del mismo, y uso de un compuesto de la fórmula (1) o una sal farmacéuticamente aceptable del mismo en terapia, lo cual incluye, en el tratamiento de una enfermedad o afección para la cual está indicado un antagonista de la integrina aᵛb₆, y en particular, en el tratamiento de fibrosis pulmonar idiopática.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1604681.5A GB201604681D0 (en) | 2016-03-21 | 2016-03-21 | Chemical Compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR107927A1 true AR107927A1 (es) | 2018-06-28 |
Family
ID=55968580
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP170100685A AR107927A1 (es) | 2016-03-21 | 2017-03-20 | Compuestos de pirrolidina, sal farmacéuticamente aceptable del mismo, composición farmacéutica que lo comprende y su uso para la fabricación de un medicamento |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20210206758A1 (es) |
| EP (1) | EP3433255A1 (es) |
| JP (1) | JP2019509305A (es) |
| KR (1) | KR20180128404A (es) |
| CN (1) | CN108779114A (es) |
| AR (1) | AR107927A1 (es) |
| AU (1) | AU2017237362A1 (es) |
| BR (1) | BR112018069302A2 (es) |
| CA (1) | CA3018014A1 (es) |
| GB (1) | GB201604681D0 (es) |
| RU (1) | RU2018136888A (es) |
| TW (1) | TW201808949A (es) |
| UY (1) | UY37160A (es) |
| WO (1) | WO2017162572A1 (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201305668D0 (en) | 2013-03-28 | 2013-05-15 | Glaxosmithkline Ip Dev Ltd | Avs6 Integrin Antagonists |
| GB201417011D0 (en) | 2014-09-26 | 2014-11-12 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
| GB201417094D0 (en) | 2014-09-26 | 2014-11-12 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
| GB201417018D0 (en) | 2014-09-26 | 2014-11-12 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
| GB201604680D0 (en) | 2016-03-21 | 2016-05-04 | Glaxosmithkline Ip Dev Ltd | Chemical Compounds |
| BR112019017929A2 (pt) | 2017-02-28 | 2020-05-19 | Morphic Therapeutic Inc | inibidores de integrina (alfa-v)(beta-6) |
| US11046685B2 (en) | 2017-02-28 | 2021-06-29 | Morphic Therapeutic, Inc. | Inhibitors of (α-v)(β-6) integrin |
| PL3761980T3 (pl) | 2018-03-07 | 2024-06-10 | Pliant Therapeutics, Inc. | Związki aminokwasowe i sposoby zastosowania |
| EP4086254B1 (en) * | 2018-08-29 | 2024-12-18 | Morphic Therapeutic, Inc. | Integrin inhibitors |
| HUE071053T2 (hu) | 2018-08-29 | 2025-07-28 | Morphic Therapeutic Inc | Az alfa-V-béta-6 integrin gátlószerei |
| EP3843728B1 (en) * | 2018-08-29 | 2025-04-30 | Morphic Therapeutic, Inc. | Inhibitors of (alpha-v)(beta-6) integrin |
| CN113620938A (zh) * | 2020-05-07 | 2021-11-09 | 北京康派森医药科技有限公司 | 一种恩格列净异构体杂质的合成方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003510360A (ja) * | 1999-10-04 | 2003-03-18 | メルク エンド カムパニー インコーポレーテッド | インテグリン受容体拮抗薬 |
| IL149313A0 (en) * | 1999-11-08 | 2002-11-10 | Merck & Co Inc | Process and intermediates for the preparation of imidazolidinone alpha v integrin antagonists |
| US6921767B2 (en) | 2000-06-15 | 2005-07-26 | Pharmacia Corporation | Cycloalkyl alkanoic acids as integrin receptor antagonists derivatives |
| KR101098109B1 (ko) | 2002-03-13 | 2011-12-26 | 더 리전츠 오브 더 유니버시티 오브 캘리포니아 | 항αｖβ6 항체 |
| US20040224986A1 (en) * | 2002-08-16 | 2004-11-11 | Bart De Corte | Piperidinyl targeting compounds that selectively bind integrins |
| US9067949B2 (en) | 2011-01-19 | 2015-06-30 | Albany Molecular Research, Inc. | Benzofuro[3,2-c] pyridines and related analogs as serotonin sub-type 6 (5-HT6) modulators for the treatment of obesity, metabolic syndrome, cognition and schizophrenia |
| US20150178760A1 (en) | 2012-07-24 | 2015-06-25 | Empire Technology Development Llc | Methods for valuation of recycling credits |
| GB201305668D0 (en) * | 2013-03-28 | 2013-05-15 | Glaxosmithkline Ip Dev Ltd | Avs6 Integrin Antagonists |
| GB201417011D0 (en) * | 2014-09-26 | 2014-11-12 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
| GB201417002D0 (en) | 2014-09-26 | 2014-11-12 | Glaxosmithkline Ip Dev Ltd | Novel compound |
-
2016
- 2016-03-21 GB GBGB1604681.5A patent/GB201604681D0/en not_active Ceased
-
2017
- 2017-03-20 KR KR1020187026956A patent/KR20180128404A/ko not_active Withdrawn
- 2017-03-20 TW TW106109085A patent/TW201808949A/zh unknown
- 2017-03-20 EP EP17712110.0A patent/EP3433255A1/en not_active Withdrawn
- 2017-03-20 RU RU2018136888A patent/RU2018136888A/ru not_active Application Discontinuation
- 2017-03-20 AR ARP170100685A patent/AR107927A1/es unknown
- 2017-03-20 WO PCT/EP2017/056527 patent/WO2017162572A1/en not_active Ceased
- 2017-03-20 US US16/087,349 patent/US20210206758A1/en not_active Abandoned
- 2017-03-20 CN CN201780017963.4A patent/CN108779114A/zh active Pending
- 2017-03-20 AU AU2017237362A patent/AU2017237362A1/en not_active Abandoned
- 2017-03-20 JP JP2018549509A patent/JP2019509305A/ja active Pending
- 2017-03-20 CA CA3018014A patent/CA3018014A1/en not_active Abandoned
- 2017-03-20 BR BR112018069302A patent/BR112018069302A2/pt not_active Application Discontinuation
- 2017-03-20 UY UY0001037160A patent/UY37160A/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CA3018014A1 (en) | 2017-09-28 |
| CN108779114A (zh) | 2018-11-09 |
| RU2018136888A (ru) | 2020-04-22 |
| US20210206758A1 (en) | 2021-07-08 |
| JP2019509305A (ja) | 2019-04-04 |
| TW201808949A (zh) | 2018-03-16 |
| WO2017162572A1 (en) | 2017-09-28 |
| GB201604681D0 (en) | 2016-05-04 |
| KR20180128404A (ko) | 2018-12-03 |
| EP3433255A1 (en) | 2019-01-30 |
| AU2017237362A1 (en) | 2018-08-09 |
| UY37160A (es) | 2017-09-29 |
| BR112018069302A2 (pt) | 2019-01-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |