AR106924A2 - PHARMACOCINETIC PROPERTIES MODULATORS OF THERAPEUTICS - Google Patents

Abstract

The present application provides a compound, a pharmaceutically acceptable salt, solvate, and / or ester thereof, compositions containing said compounds, and therapeutic methods that include the administration of said compounds, and therapeutic methods, and include the administration of said compounds with at least one additional therapeutic agent. Claim 1: A compound characterized in that it is of the formula (1), wherein, L¹ is selected from the group consisting of -C (R⁶) ₂-, -C (O) -, -S (O) ₂-, -N (R⁷) -C (O) -, and -OC (O) -; L² is a covalent bond, -C (R⁶) ₂- or -C (O) -; each L³ is independently a covalent bond, an alkylene, or a substituted alkylene; each L⁴ is independently selected from the group consisting of a covalent bond, alkylene, substituted alkylene, -O-, -CH₂-O-, and -NH-; each A is independently selected from the group consisting of H, alkyl, substituted alkyl, aryl, substituted aryl, heterocyclyl, and substituted heterocyclyl, with the proviso that when A is H, p is 0; Z¹ and Z² are each independently -O- or -N (R⁷) -; Y and X are independently selected from the group consisting of heterocyclyl and heterocyclylalkyl; each Ar is independently selected from the group consisting of aryl, substituted aryl, heteroaryl and substituted heteroaryl; R¹, R³, and R⁵ are each independently selected from the group consisting of H, alkyl, substituted alkyl, arylalkyl, and substituted arylalkyl; each R² is independently selected from the group consisting of H, alkyl, substituted alkyl, alkoxyalkyl, hydroxyalkyl, arylheteroalkyl, substituted arylheteroalkyl, arylalkyl, substituted arylalkyl, heterocyclylalkyl, substituted heterocyclyl alkyl, aminoalkyl, substituted C-alkyl-alkyl , -alkylene-C (O) -O-alkyl, -alkylene-C (O) amino, -alkylene-C (O) -alkyl; R⁴ and R⁶ are independently selected from the group consisting of H, alkyl, substituted alkyl, and heteroalkyl; each R⁷ is independently selected from the group consisting of H, alkyl, substituted alkyl, heteroalkyl, carbocyclyl, substituted carbocyclyl, heterocyclyl, and substituted heterocyclyl; R⁸ and R⁹ are each, one or more substituents independently selected from the group consisting of H, alkyl, substituted alkyl, halogen, aryl, substituted aryl, heterocyclyl, substituted heterocyclyl, and -CN; m is 1 or 2; n is 0 or 1; and each p is independently 0 or 1; or a pharmaceutically acceptable salt, solvate and / or ester thereof.