AR106774A1 - ANTIBODIES AND ANTIBODY FRAGMENTS FOR SITE-SPECIFIC CONJUGATION - Google Patents
ANTIBODIES AND ANTIBODY FRAGMENTS FOR SITE-SPECIFIC CONJUGATIONInfo
- Publication number
- AR106774A1 AR106774A1 ARP160103566A ARP160103566A AR106774A1 AR 106774 A1 AR106774 A1 AR 106774A1 AR P160103566 A ARP160103566 A AR P160103566A AR P160103566 A ARP160103566 A AR P160103566A AR 106774 A1 AR106774 A1 AR 106774A1
- Authority
- AR
- Argentina
- Prior art keywords
- antibodies
- site
- specific conjugation
- antibody fragments
- cysteine
- Prior art date
Links
- 230000021615 conjugation Effects 0.000 title abstract 2
- 102000008394 Immunoglobulin Fragments Human genes 0.000 title 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 title 1
- 125000000151 cysteine group Chemical class N[C@@H](CS)C(=O)* 0.000 abstract 2
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- -1 antibodies Proteins 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 abstract 1
- 235000018417 cysteine Nutrition 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
Landscapes
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La divulgación se relaciona con polipéptidos, anticuerpos, y fragmentos de unión al antígeno de los mismos, que comprenden una cisteína sustituida para la conjugación sitio-especifica. Reivindicación 1: Un polipéptido que comprende un dominio constante de cadena pesada de anticuerpo que comprende un residuo de cisteína diseñada en la posición 290, de acuerdo con la numeración del índice EU de Kabat.The disclosure relates to polypeptides, antibodies, and antigen binding fragments thereof, which comprise a substituted cysteine for site-specific conjugation. Claim 1: A polypeptide comprising a constant heavy chain antibody domain comprising a cysteine residue designed at position 290, in accordance with the Kabat EU index numbering.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562260854P | 2015-11-30 | 2015-11-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR106774A1 true AR106774A1 (en) | 2018-02-14 |
Family
ID=61247585
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP160103565A AR106773A1 (en) | 2015-11-30 | 2016-11-21 | HER2 ANTIBODY DRUG CONJUGATES SITE SPECIFICATIONS |
| ARP160103566A AR106774A1 (en) | 2015-11-30 | 2016-11-21 | ANTIBODIES AND ANTIBODY FRAGMENTS FOR SITE-SPECIFIC CONJUGATION |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP160103565A AR106773A1 (en) | 2015-11-30 | 2016-11-21 | HER2 ANTIBODY DRUG CONJUGATES SITE SPECIFICATIONS |
Country Status (1)
| Country | Link |
|---|---|
| AR (2) | AR106773A1 (en) |
-
2016
- 2016-11-21 AR ARP160103565A patent/AR106773A1/en not_active Application Discontinuation
- 2016-11-21 AR ARP160103566A patent/AR106774A1/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AR106773A1 (en) | 2018-02-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |