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AR104114A1 - Péptidos y combinación de péptidos y andamiajes para su uso en inmunoterapia contra carcinoma de células renales (rcc) y otros cánceres - Google Patents

Péptidos y combinación de péptidos y andamiajes para su uso en inmunoterapia contra carcinoma de células renales (rcc) y otros cánceres

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Publication number
AR104114A1
AR104114A1 ARP160100819A ARP160100819A AR104114A1 AR 104114 A1 AR104114 A1 AR 104114A1 AR P160100819 A ARP160100819 A AR P160100819A AR P160100819 A ARP160100819 A AR P160100819A AR 104114 A1 AR104114 A1 AR 104114A1
Authority
AR
Argentina
Prior art keywords
cancer
peptide
seq
variant
antigen
Prior art date
Application number
ARP160100819A
Other languages
English (en)
Inventor
Song Colette
Dr Singh Harpreet
fritsche Jens
Dr Schoor Oliver
Dr Weinschenk Toni
Dr Mahr Andrea
Original Assignee
Immatics Biotechnologies Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immatics Biotechnologies Gmbh filed Critical Immatics Biotechnologies Gmbh
Publication of AR104114A1 publication Critical patent/AR104114A1/es

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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
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    • C07K16/3038—Kidney, bladder
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)

Abstract

Reivindicación 1: Un péptido caracterizado porque comprende una secuencia de aminoácidos que se elige del grupo que consiste en SEQ ID Nº 1 a SEQ ID Nº 114, y secuencias variantes de las mismas que son por lo menos 88% homólogas a SEQ ID Nº 1 a SEQ ID Nº 114; y una sal farmacéuticamente aceptable de las mismas, en donde dicho péptido no es un polipéptido de longitud completa. Reivindicación 7: Un ácido nucleico, caracterizado porque codifica para un péptido o variante del mismo de acuerdo a cualquiera de las reivindicaciones 1 a 6, opcionalmente conectado a una secuencia promotora heteróloga. Reivindicación 12: Un método in vitro para producir linfocitos T activados, caracterizado porque el método comprende poner en contacto in vitro células T con moléculas MHC de clase I o II humanas cargadas con antígeno expresadas sobre la superficie de una célula presentadora de antígeno adecuada o una construcción artificial que imita una célula presentadora de antígeno durante un periodo de tiempo suficiente para activar a dichas células T de una forma específica de antígeno, en donde dicho antígeno es un péptido de acuerdo a cualquiera de las reivindicaciones 1 a 6. Reivindicación 15: Un anticuerpo, en particular un anticuerpo soluble o unido a membrana, caracterizado porque reconoce específicamente el péptido o variante del mismo de acuerdo a cualquiera de las reivindicaciones 1 a 5, preferiblemente el péptido o variante del mismo de acuerdo a cualquiera de las reivindicaciones 1 a 5 cuando está unido a una molécula MHC en donde el anticuerpo porta una función efectora adicional tal como un dominio o toxina de estimulación inmune. Reivindicación 18: El uso de acuerdo a la reivindicación 16, caracterizado porque dicho cáncer se elige del grupo de cáncer de pulmón, cáncer de cerebro, cáncer gástrico, cáncer colorrectal, cáncer hepático, cáncer pancreático, cáncer de próstata, leucemia, cáncer de mama, melanoma, cáncer ovárico, y cáncer esofágico y otros tumores que muestran una sobreexpresión de de la que deriva el péptido de SEQ ID Nº 1 a SEQ ID Nº 114. Reivindicación 40: Un aptámero caracterizado porque reconoce específicamente el péptido o variante del mismo de acuerdo a cualquiera de las reivindicaciones 1 a 5, preferiblemente el péptido o variante del mismo de acuerdo a cualquiera de las reivindicaciones 1 a 5 que está unido a una molécula de MHC.
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JP6559227B2 (ja) * 2014-08-17 2019-08-14 セリベリー セラピューティクス，インコーポレーテッド 細胞透過性の改善のための進化型巨大分子伝達ドメイン（ａｄｖａｎｃｅｄ ｍａｃｒｏｍｏｌｅｃｕｌｅ ｔｒａｎｓｄｕｃｔｉｏｎ ｄｏｍａｉｎ）（ＡＭＴＤ）配列、それをコードするポリヌクレオチド、それを含むＡＭＴＤの固有の特性を同定する方法、それを含むＡＭＴＤ配列を開発する方法
PL3388075T3 (pl) 2015-03-27 2023-12-11 Immatics Biotechnologies Gmbh Nowe peptydy i kombinacja peptydów do stosowania w immunoterapii względem różnych nowotworów
GB201505585D0 (en) 2015-03-31 2015-05-13 Immatics Biotechnologies Gmbh Novel peptides and combination of peptides and scaffolds for use in immunotherapy against renal cell carinoma (RCC) and other cancers

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