AR091234A1 - Formulaciones farmaceuticas basadas en genotipos o fenotipos, procedimiento para prepararlas - Google Patents
Formulaciones farmaceuticas basadas en genotipos o fenotipos, procedimiento para prepararlasInfo
- Publication number
- AR091234A1 AR091234A1 ARP130101928A AR091234A1 AR 091234 A1 AR091234 A1 AR 091234A1 AR P130101928 A ARP130101928 A AR P130101928A AR 091234 A1 AR091234 A1 AR 091234A1
- Authority
- AR
- Argentina
- Prior art keywords
- variants
- metabolite
- genotypes
- phenotypes
- prepare
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- NKANXQFJJICGDU-QPLCGJKRSA-N Tamoxifen Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=CC(OCCN(C)C)=CC=1)/C1=CC=CC=C1 NKANXQFJJICGDU-QPLCGJKRSA-N 0.000 abstract 4
- 239000002207 metabolite Substances 0.000 abstract 3
- 239000000126 substance Substances 0.000 abstract 3
- 238000009472 formulation Methods 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 229960001603 tamoxifen Drugs 0.000 abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000002503 metabolic effect Effects 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B5/00—ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Computational Biology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Evolutionary Biology (AREA)
- Medical Informatics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Theoretical Computer Science (AREA)
- Physiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Endocrinology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Una combinación de dos o más sustancias farmacéuticamente activas, de las cuales al menos una es un producto metabólico (metabolito) de la otra (sustancia original), en la que en particular sus dosificaciones se seleccionan de modo tal que la variabilidad relacionada con el genotipo o el fenotipo en la conversión de la sustancia original al metabolito en individuos particulares está compensada. Reivindicación 1: Formulación farmacéutica de combinación en dosis fijas que contiene una sustancia original, cuya acción depende de la cantidad o de la actividad de las variantes de proteína expresadas, las variantes enzimáticas, las variantes del receptor o las variantes del transportador, y al menos un metabolito de la misma. Reivindicación 3: Formulación de acuerdo con cualquiera de las reivindicaciones 1 y 2 que comprende tamoxifeno y endoxifeno. Reivindicación 4: Formulación de acuerdo con la reivindicación 3 que comprende 15 - 25 mg de tamoxifeno y 0,25 - 5,0 mg de endoxifeno.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12170401.9A EP2668945A1 (de) | 2012-06-01 | 2012-06-01 | Genotyp- bzw. Phänotyp-basierte Arzeimittelformulierungen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR091234A1 true AR091234A1 (es) | 2015-01-21 |
Family
ID=48520964
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP130101928 AR091234A1 (es) | 2012-06-01 | 2013-05-31 | Formulaciones farmaceuticas basadas en genotipos o fenotipos, procedimiento para prepararlas |
| ARP200101246A AR118842A2 (es) | 2012-06-01 | 2020-04-30 | Composición farmacéutica que contiene tamoxifen y endoxifen y procedimiento para prepararla |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP200101246A AR118842A2 (es) | 2012-06-01 | 2020-04-30 | Composición farmacéutica que contiene tamoxifen y endoxifen y procedimiento para prepararla |
Country Status (23)
| Country | Link |
|---|---|
| US (3) | US10285958B2 (es) |
| EP (2) | EP2668945A1 (es) |
| JP (2) | JP6096289B2 (es) |
| KR (1) | KR102129043B1 (es) |
| CN (2) | CN110075097A (es) |
| AR (2) | AR091234A1 (es) |
| AU (1) | AU2013269793B2 (es) |
| BR (1) | BR112014030059B1 (es) |
| CA (1) | CA2875189C (es) |
| DK (1) | DK2854789T3 (es) |
| ES (1) | ES2744306T3 (es) |
| HK (1) | HK1207296A1 (es) |
| HU (1) | HUE045699T2 (es) |
| IL (1) | IL235988B (es) |
| MX (1) | MX370304B (es) |
| NZ (1) | NZ702849A (es) |
| PL (1) | PL2854789T3 (es) |
| PT (1) | PT2854789T (es) |
| RU (1) | RU2683260C2 (es) |
| SA (1) | SA113340607B1 (es) |
| SG (2) | SG10201610072UA (es) |
| TW (1) | TWI644666B (es) |
| WO (1) | WO2013178565A1 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2668945A1 (de) | 2012-06-01 | 2013-12-04 | Bayer Technology Services GmbH | Genotyp- bzw. Phänotyp-basierte Arzeimittelformulierungen |
| US11965206B2 (en) | 2018-12-21 | 2024-04-23 | John Stoddard | Method of dosing a patient with multiple drugs using adjusted phenotypes of CYP450 enzymes |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1317546C (en) * | 1985-07-01 | 1993-05-11 | Werner Meier | Pharmaceutical preparations containing mixtures of hydroxy derivatives of vitamin d |
| US6048857A (en) | 1989-10-17 | 2000-04-11 | Ellinwood, Jr.; Everett H. | Dosing method of administering medicaments via inhalation administration |
| US5580728A (en) | 1994-06-17 | 1996-12-03 | Perlin; Mark W. | Method and system for genotyping |
| US6017963A (en) * | 1995-11-14 | 2000-01-25 | Euro-Celtique, S.A. | Formulation for intranasal administration |
| US6760708B1 (en) | 1999-08-19 | 2004-07-06 | Dell Products L.P. | Method and system for migrating stored data to a build-to-order computing system |
| US20020012921A1 (en) | 2000-01-21 | 2002-01-31 | Stanton Vincent P. | Identification of genetic components of drug response |
| US7427480B2 (en) | 2002-03-26 | 2008-09-23 | Perlegen Sciences, Inc. | Life sciences business systems and methods |
| CN102349927A (zh) * | 2003-08-29 | 2012-02-15 | Hdac默克研究有限责任公司 | 联合治疗癌症的方法 |
| US7504214B2 (en) * | 2003-09-19 | 2009-03-17 | Biotheranostics, Inc. | Predicting outcome with tamoxifen in breast cancer |
| DE10345836A1 (de) | 2003-10-02 | 2005-04-21 | Bayer Technology Services Gmbh | Verfahren zur Simulation der Wechselwirkung von chemischen Substanzen mit lebenden Organismen |
| JP4732683B2 (ja) | 2003-12-29 | 2011-07-27 | ユニバーサル・バイオ・リサーチ株式会社 | 標的物質の検出方法 |
| WO2005092314A1 (en) | 2004-03-18 | 2005-10-06 | Istituto Nazionale Per Lo Studio E La Cura Del Tum | 4-oxo-fenretinide, administered alone and in combination with fenretinide, as preventive and therapeutic agent for cancer |
| WO2005094363A2 (en) | 2004-03-30 | 2005-10-13 | New York University | System, method and software arrangement for bi-allele haplotype phasing |
| DE102004025534A1 (de) | 2004-05-25 | 2005-12-15 | Bayer Technology Services Gmbh | Verfahren zur (zweistufigen) Dosis- und Dosierungsfindung |
| US8024128B2 (en) | 2004-09-07 | 2011-09-20 | Gene Security Network, Inc. | System and method for improving clinical decisions by aggregating, validating and analysing genetic and phenotypic data |
| US8147615B2 (en) | 2004-11-05 | 2012-04-03 | Infineon Technologies Ag | Method of fabricating semiconductor cleaners |
| WO2006130843A1 (en) * | 2005-06-02 | 2006-12-07 | Biovail Laboratories International S.R.L. | Modified-release composition of at least one form of venlafaxine |
| US20070122824A1 (en) | 2005-09-09 | 2007-05-31 | Tucker Mark R | Method and Kit for Assessing a Patient's Genetic Information, Lifestyle and Environment Conditions, and Providing a Tailored Therapeutic Regime |
| WO2007035613A1 (en) | 2005-09-19 | 2007-03-29 | Bg Medicine, Inc. | Correlation analysis of biological systems |
| RU2318508C2 (ru) * | 2005-12-28 | 2008-03-10 | Всеволод Иванович Киселев | Фармацевтическая композиция для лечения и профилактики пролиферативных заболеваний молочной железы |
| FR2896896B1 (fr) | 2006-02-02 | 2009-09-25 | Commissariat Energie Atomique | Procede de classification d'evenements ou d'etats en deux etapes |
| DE102006028232A1 (de) | 2006-06-20 | 2007-12-27 | Bayer Technology Services Gmbh | Vorrichtung und Verfahren zur Berechnung und Bereitstellung einer Medikamentendosis |
| US20090291134A1 (en) | 2006-11-21 | 2009-11-26 | Jina Pharmaceuticals, Inc. | Endoxifen methods and compositions in the treatment of psychiatric and neurodegenerative diseases |
| JP2010510327A (ja) | 2006-11-21 | 2010-04-02 | ジャイナ ファーマシューティカルズ，インコーポレーテッド | エンドキシフェンの方法および組成物 |
| US8099298B2 (en) | 2007-02-14 | 2012-01-17 | Genelex, Inc | Genetic data analysis and database tools |
| EP2266067A4 (en) | 2008-02-26 | 2011-04-13 | Purdue Research Foundation | METHOD OF PATIENT GENOTYPING |
| WO2009120999A2 (en) * | 2008-03-28 | 2009-10-01 | Olema Pharmaceuticals, Inc. | Use of an endoxifen prodrug for treatment of breast cancer |
| WO2009137543A2 (en) * | 2008-05-06 | 2009-11-12 | Ore Pharmaceuticals Inc. | Methods for breast cancer screening and treatment |
| AU2009267052B2 (en) | 2008-06-30 | 2013-07-11 | Tocagen Inc. | Formulations of 5-fluorocytosine and uses thereof |
| JP4517312B2 (ja) * | 2008-07-08 | 2010-08-04 | ソニー株式会社 | メモリアクセス制御装置および撮像装置 |
| US20110136913A1 (en) * | 2008-08-19 | 2011-06-09 | Goetz Matthew P | Assessing and treating breast cancer patients |
| WO2010036732A1 (en) | 2008-09-25 | 2010-04-01 | Zeltiq Aesthetics, Inc. | Treatment planning systems and methods for body contouring applications |
| US7873482B2 (en) | 2008-12-16 | 2011-01-18 | Bruno Stefanon | Diagnostic system for selecting nutrition and pharmacological products for animals |
| WO2010096834A2 (en) * | 2009-02-23 | 2010-08-26 | Indiana University Research & Technology Corporation | Materials and methods for treating patients with tamoxifen |
| WO2011072244A1 (en) * | 2009-12-10 | 2011-06-16 | Mount Sinai School Of Medicine Of New York University | Method of treatment of breast cancer with tamoxifen |
| US9372198B2 (en) | 2010-06-17 | 2016-06-21 | Aradigm Corporation | Diagnosis of entry of gastrointestinal contents into respiratory tract of humans and animals |
| NZ606903A (en) * | 2010-08-26 | 2015-05-29 | Ipca Lab Ltd | Methods for the treatment or prophylaxis of thrombosis or embolism |
| BR112013033464A2 (pt) * | 2011-06-27 | 2017-01-24 | Ipca Lab Ltd | composto, acetato, composição farmacêutica, combinação farmacêutica, método e método melhorado |
| MX375673B (es) | 2012-04-02 | 2025-03-06 | Berg Llc | Ensayos basados en interrogatorios celulares y usos de los mismos. |
| EP2668945A1 (de) | 2012-06-01 | 2013-12-04 | Bayer Technology Services GmbH | Genotyp- bzw. Phänotyp-basierte Arzeimittelformulierungen |
| US9417221B2 (en) | 2013-08-27 | 2016-08-16 | International Business Machines Corporation | Food steganography |
-
2012
- 2012-06-01 EP EP12170401.9A patent/EP2668945A1/de not_active Withdrawn
-
2013
- 2013-05-27 ES ES13725157T patent/ES2744306T3/es active Active
- 2013-05-27 MX MX2014014596A patent/MX370304B/es active IP Right Grant
- 2013-05-27 EP EP13725157.5A patent/EP2854789B1/de active Active
- 2013-05-27 WO PCT/EP2013/060824 patent/WO2013178565A1/de not_active Ceased
- 2013-05-27 DK DK13725157.5T patent/DK2854789T3/da active
- 2013-05-27 PL PL13725157T patent/PL2854789T3/pl unknown
- 2013-05-27 NZ NZ702849A patent/NZ702849A/en unknown
- 2013-05-27 CN CN201910317702.5A patent/CN110075097A/zh active Pending
- 2013-05-27 HU HUE13725157A patent/HUE045699T2/hu unknown
- 2013-05-27 CA CA2875189A patent/CA2875189C/en active Active
- 2013-05-27 AU AU2013269793A patent/AU2013269793B2/en active Active
- 2013-05-27 PT PT13725157T patent/PT2854789T/pt unknown
- 2013-05-27 BR BR112014030059-3A patent/BR112014030059B1/pt active IP Right Grant
- 2013-05-27 HK HK15107896.3A patent/HK1207296A1/xx unknown
- 2013-05-27 SG SG10201610072UA patent/SG10201610072UA/en unknown
- 2013-05-27 SG SG11201407791VA patent/SG11201407791VA/en unknown
- 2013-05-27 CN CN201380040850.8A patent/CN104507464A/zh active Pending
- 2013-05-27 JP JP2015514441A patent/JP6096289B2/ja active Active
- 2013-05-27 KR KR1020147036212A patent/KR102129043B1/ko active Active
- 2013-05-27 RU RU2014154140A patent/RU2683260C2/ru active
- 2013-05-27 US US14/403,823 patent/US10285958B2/en active Active
- 2013-05-31 TW TW102119266A patent/TWI644666B/zh active
- 2013-05-31 AR ARP130101928 patent/AR091234A1/es unknown
- 2013-06-01 SA SA113340607A patent/SA113340607B1/ar unknown
-
2014
- 2014-11-30 IL IL235988A patent/IL235988B/en active IP Right Grant
-
2016
- 2016-11-09 JP JP2016219156A patent/JP2017048234A/ja active Pending
-
2017
- 2017-01-31 US US15/420,733 patent/US20170326080A1/en not_active Abandoned
- 2017-06-16 US US15/625,553 patent/US20170326081A1/en not_active Abandoned
-
2020
- 2020-04-30 AR ARP200101246A patent/AR118842A2/es not_active Application Discontinuation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure | ||
| FB | Suspension of granting procedure |