AR099880A1 - Derivados de nicotinamida como moduladores de trpa1 - Google Patents
Derivados de nicotinamida como moduladores de trpa1Info
- Publication number
- AR099880A1 AR099880A1 ARP150100930A ARP150100930A AR099880A1 AR 099880 A1 AR099880 A1 AR 099880A1 AR P150100930 A ARP150100930 A AR P150100930A AR P150100930 A ARP150100930 A AR P150100930A AR 099880 A1 AR099880 A1 AR 099880A1
- Authority
- AR
- Argentina
- Prior art keywords
- trpa1
- nicotinamide derivatives
- modulators
- trpa1 modulators
- cycloalkyl
- Prior art date
Links
- 101000764872 Homo sapiens Transient receptor potential cation channel subfamily A member 1 Proteins 0.000 title abstract 3
- 102100026186 Transient receptor potential cation channel subfamily A member 1 Human genes 0.000 title abstract 3
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical class NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 title 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI20140092 | 2014-03-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR099880A1 true AR099880A1 (es) | 2016-08-24 |
Family
ID=53005579
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP150100930A AR099880A1 (es) | 2014-03-28 | 2015-03-27 | Derivados de nicotinamida como moduladores de trpa1 |
Country Status (3)
| Country | Link |
|---|---|
| AR (1) | AR099880A1 (zh) |
| TW (1) | TW201620876A (zh) |
| WO (1) | WO2015144976A1 (zh) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104822653B (zh) * | 2012-10-01 | 2017-03-08 | 奥赖恩公司 | N‑丙‑2‑炔基甲酰胺衍生物及其作为trpa1拮抗剂的用途 |
| CN109952291B (zh) * | 2016-09-12 | 2022-09-23 | 纽若斯丹公司 | 与糖尿病相关的神经缺陷的改善 |
| FR3114235A1 (fr) | 2020-09-18 | 2022-03-25 | Université Grenoble Alpes | Inhibition du canal trpa1 astrocytaire comme nouvelle cible therapeutique neuroprotectrice dans les phases prodromales de la maladie d’alzheimer |
| IT202100015098A1 (it) | 2021-06-09 | 2022-12-09 | Flonext S R L | Composto antagonista del canale trpa1 per uso in patologie degenerative della retina |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2723751A1 (en) * | 2008-05-05 | 2009-11-12 | Allergan, Inc. | Alpha2b and alpha2c agonists |
| CN104822653B (zh) * | 2012-10-01 | 2017-03-08 | 奥赖恩公司 | N‑丙‑2‑炔基甲酰胺衍生物及其作为trpa1拮抗剂的用途 |
-
2015
- 2015-03-26 TW TW104109725A patent/TW201620876A/zh unknown
- 2015-03-27 AR ARP150100930A patent/AR099880A1/es unknown
- 2015-03-27 WO PCT/FI2015/000012 patent/WO2015144976A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| TW201620876A (zh) | 2016-06-16 |
| WO2015144976A1 (en) | 2015-10-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL285114B1 (en) | Aryl, heteroaryl, and heterocyclic compounds for treatment of complement mediated disorders | |
| CO2017006826A2 (es) | Compuestos de picolinamida con actividad fungicida con actividad fungicida | |
| NZ732799A (en) | Picolinamides with fungicidal activity | |
| CO2019005165A2 (es) | Compuesto de piridona como inhibidor de c-met | |
| MX2017008439A (es) | Compuestos de picolinamida con actividad fungicida. | |
| EA201690713A1 (ru) | Гетероциклические соединения и их применения | |
| PT3240773T (pt) | Compostos picolinamida com atividade fungicida | |
| EA201692105A1 (ru) | Новые пиразолопиримидиновые производные и их применение в качестве ингибиторов malt1 | |
| EA201692203A1 (ru) | Соединения, ингибирующие tank-связывающую киназу | |
| MX2015017532A (es) | Métodos para modular la actividad del regulador de transmembrana de fibrosis quística. | |
| BR112017013062A2 (pt) | compostos picolinamida macrocíclicos com atividade fungicida. | |
| MX372740B (es) | Derivado de 2,4-diaminopirimidina biciclico fusionado como un inhibidor dual de alk y fak. | |
| EA201790599A1 (ru) | Соединения и композиции в качестве ингибиторов киназ | |
| EA201790432A1 (ru) | Зонды для визуализации белка хантингтина | |
| LT3191514T (lt) | Ligandai, sustiprinantys gonadotropinų biologinį aktyvumą | |
| EA201691412A1 (ru) | Гидроксиформамидные производные и их применение | |
| DK3778573T3 (da) | Forbindelse med anticanceraktivitet | |
| EP3641758A4 (en) | Compounds for the reduction of the deleterious activity of extended nucleotide repeat containing genes | |
| AR099880A1 (es) | Derivados de nicotinamida como moduladores de trpa1 | |
| EA201790687A1 (ru) | Хинолинкарбоксамиды для применения в лечении множественной миеломы | |
| AR098037A1 (es) | Derivados de piperazina y su uso como medicamento | |
| EA201791099A1 (ru) | Хинолин карбоксамиды для применения в лечении лейкоза | |
| IT201700033290A1 (it) | “letto migliorato” | |
| UA98922U (ru) | 2-((4-амино-5(4-нитро фенил)-1,2,4-триазол-3-ил)тио)ацетонитрил, проявляющая диуретическую активность | |
| UA99044U (ru) | (4-амино-3-(децилтио)-1,2,4-триазол-5-ил)(фенил)метанола, проявляющей диуретическую активность |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |