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AR098871A1 - Métodos de proceso para inhibidores de fosfatidilinositol 3-quinasa - Google Patents

Métodos de proceso para inhibidores de fosfatidilinositol 3-quinasa

Info

Publication number
AR098871A1
AR098871A1 ARP140104806A ARP140104806A AR098871A1 AR 098871 A1 AR098871 A1 AR 098871A1 AR P140104806 A ARP140104806 A AR P140104806A AR P140104806 A ARP140104806 A AR P140104806A AR 098871 A1 AR098871 A1 AR 098871A1
Authority
AR
Argentina
Prior art keywords
compound
formula
salts
salt
group
Prior art date
Application number
ARP140104806A
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English (en)
Original Assignee
Gilead Calistoga Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=52355226&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR098871(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Gilead Calistoga Llc filed Critical Gilead Calistoga Llc
Publication of AR098871A1 publication Critical patent/AR098871A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/20—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 4
    • C07D265/22—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/536—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/90—Carboxylic acid amides having nitrogen atoms of carboxamide groups further acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C265/00—Derivatives of isocyanic acid
    • C07C265/10—Derivatives of isocyanic acid having isocyanate groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/91—Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/06—1,3-Oxazines; Hydrogenated 1,3-oxazines not condensed with other rings
    • C07D265/08—1,3-Oxazines; Hydrogenated 1,3-oxazines not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D265/10—1,3-Oxazines; Hydrogenated 1,3-oxazines not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with oxygen atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

En la presente, se revela un proceso para la síntesis de compuestos que contienen quinazolinona que pueden ser útiles para el tratamiento de cáncer. Además, también se revelan compuestos intermediarios relacionados con estos procesos. Reivindicación 1: Un proceso para sintetizar un compuesto de la fórmula (1) o una de sus sales, que comprende etapa a) combinar un compuesto de la fórmula (2) o una de sus sales, y un compuesto de la fórmula (3), en donde se sintetiza el compuesto de la fórmula (1) o una de sus sales, en donde R¹ es halo; R² está seleccionado del grupo que consiste en H y alquilo C₁₋₈ opcionalmente sustituido; y R³ y R⁴ están seleccionados cada uno, de modo independiente, del grupo que consiste en hidrógeno, un grupo protector amino y un grupo purinilo opcionalmente sustituido. Reivindicación 2: El proceso de acuerdo con la reivindicación 1, que también comprende etapa b) de combinación del compuesto de la fórmula (1) o una de sus sales; y un compuesto de la fórmula (9) en donde n es 0 - 5; y cada R⁵ está seleccionado, de modo independiente, del grupo que consiste en alquilo, alquenilo, alquinilo, carboxi, carboxialquilo, aminocarbonilo, hidroxi, alcoxi, halógeno, CF₃, amino, amino sustituido, nitro, tiol, ciano, cicloalquilo, heterociclilo, arilo y heteroarilo; y en donde se sintetiza un compuesto de la fórmula (4) o una de sus sales. Reivindicación 3: El proceso de acuerdo con la reivindicación 2 que también comprende etapa c) de combinación del compuesto de la fórmula (4) o una de sus sales, en donde al menos uno de R³ y R⁴ del compuesto de la fórmula (4) es un grupo protector amino; y uno o varios reactivos, en donde los uno o varios reactivos se usan para remover el grupo protector amino; en donde se sintetiza un compuesto de la fórmula (5) o una de sus sales; etapa d) de combinación del compuesto de la fórmula (5) o una de sus sales y un compuesto de la fórmula (6), en donde X está seleccionado del grupo que consiste en halógeno, mesilo, mesilato, tosilo y tosilato; y R⁶ es hidrógeno o un grupo protector amino; en donde se sintetiza un compuesto de la fórmula (7) o una de sus sales; y si R⁶ es un grupo protector amino, la etapa e) que también comprende el compuesto de la fórmula (7) o una de sus sales; y uno o varios reactivos, en donde los uno o varios reactivos se usan para remover el grupo protector amino, en donde se sintetiza un compuesto de la fórmula (10) o una de sus sales. Reivindicación 70: Un compuesto de la fórmula (8) o una de sus sales. Reivindicación 71: Un compuesto de la fórmula (11) o una de sus sales. Reivindicación 72: Un compuesto de la fórmula (12) o una de sus sales. Reivindicación 73: Un compuesto de la fórmula (13) o una de sus sales. Reivindicación 74: Un compuesto de la fórmula (14) o una de sus sales. Reivindicación 75: Un compuesto de la fórmula (15) o una de sus sales.
ARP140104806A 2013-12-20 2014-12-19 Métodos de proceso para inhibidores de fosfatidilinositol 3-quinasa AR098871A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361919548P 2013-12-20 2013-12-20

Publications (1)

Publication Number Publication Date
AR098871A1 true AR098871A1 (es) 2016-06-22

Family

ID=52355226

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP140104806A AR098871A1 (es) 2013-12-20 2014-12-19 Métodos de proceso para inhibidores de fosfatidilinositol 3-quinasa

Country Status (20)

Country Link
US (5) US9567337B2 (es)
EP (2) EP3594215A1 (es)
JP (1) JP2017502021A (es)
KR (1) KR20160095161A (es)
CN (1) CN105849108A (es)
AR (1) AR098871A1 (es)
AU (2) AU2014364410B2 (es)
CA (1) CA2934531C (es)
EA (1) EA201690990A1 (es)
ES (1) ES2752552T3 (es)
HK (1) HK1224281A1 (es)
IL (1) IL246127A0 (es)
MX (1) MX2016008259A (es)
NZ (2) NZ720867A (es)
PL (1) PL3083630T3 (es)
PT (1) PT3083630T (es)
SG (1) SG11201604825VA (es)
SI (1) SI3083630T1 (es)
TW (1) TW201609679A (es)
WO (1) WO2015095601A1 (es)

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