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AR098155A1 - Métodos para diagnosticar y tratar trastornos eosinofílicos - Google Patents

Métodos para diagnosticar y tratar trastornos eosinofílicos

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Publication number
AR098155A1
AR098155A1 ARP140103970A ARP140103970A AR098155A1 AR 098155 A1 AR098155 A1 AR 098155A1 AR P140103970 A ARP140103970 A AR P140103970A AR P140103970 A ARP140103970 A AR P140103970A AR 098155 A1 AR098155 A1 AR 098155A1
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AR
Argentina
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level
sample
patient
methods
mrna
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ARP140103970A
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Genentech Inc
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Publication of AR098155A1 publication Critical patent/AR098155A1/es

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Abstract

Se proporcionan los métodos de diagnosticar y tratar trastornos relacionados con el exceso de cantidades o actividad de eosinófilos, que incluye pero sin limitación asma. También se proporcionan los métodos de seleccionar o identificar pacientes para el tratamiento con ciertos agentes terapéuticos que son inhibidores de TH2. Reivindicación 1: Un método para predecir la respuesta de un paciente que padece de asma o de un trastorno respiratorio a una terapia que comprende un inhibidor de la vía de TH2, el método comprende: obtener una muestra biológica del paciente, medir el nivel de mARN de al menos uno, al menos dos o al menos tres marcadores en la muestra seleccionados de CSF1, MEIS2, LGALS12, IDO1, THBS4, OLIG2, ALOX15, SIGLEC8, CCL23, PYROXD2, HSD3B7, SORD, ASB2, CACNG6, GPR44, MGAT3, SLC47A1, SMPD3, CCR3, CLC, CYP4F12, y ABTB2, comparar el nivel de mARN detectado en la muestra con un nivel de referencia, y predecir que el paciente responderá a la terapia cuando el nivel de mARN medido en la muestra es elevado comparado con el nivel de referencia y predecir que el paciente no responderá a la terapia cuando el nivel de mARN medido en la muestra es reducido comparado con el nivel de referencia.
ARP140103970A 2013-10-23 2014-10-22 Métodos para diagnosticar y tratar trastornos eosinofílicos AR098155A1 (es)

Applications Claiming Priority (1)

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US201361894831P 2013-10-23 2013-10-23

Publications (1)

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AR098155A1 true AR098155A1 (es) 2016-05-04

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ARP140103970A AR098155A1 (es) 2013-10-23 2014-10-22 Métodos para diagnosticar y tratar trastornos eosinofílicos

Country Status (14)

Country Link
US (3) US20170067108A1 (es)
EP (1) EP3060685B1 (es)
JP (2) JP6715767B2 (es)
KR (1) KR20160068802A (es)
CN (1) CN105849280B (es)
AR (1) AR098155A1 (es)
AU (1) AU2014340129A1 (es)
BR (1) BR112016008694A2 (es)
CA (1) CA2924873A1 (es)
IL (1) IL244709A0 (es)
MX (1) MX2016005159A (es)
RU (1) RU2016119425A (es)
SG (1) SG11201603127WA (es)
WO (1) WO2015061441A1 (es)

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US20200165679A1 (en) 2020-05-28
US20170067108A1 (en) 2017-03-09
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