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AR097791A1 - Formulaciones de anticuerpos anti-pdl1 - Google Patents

Formulaciones de anticuerpos anti-pdl1

Info

Publication number
AR097791A1
AR097791A1 ARP140103581A ARP140103581A AR097791A1 AR 097791 A1 AR097791 A1 AR 097791A1 AR P140103581 A ARP140103581 A AR P140103581A AR P140103581 A ARP140103581 A AR P140103581A AR 097791 A1 AR097791 A1 AR 097791A1
Authority
AR
Argentina
Prior art keywords
concentration
formulations
pdl1 antibody
antibody formulations
pdl1
Prior art date
Application number
ARP140103581A
Other languages
English (en)
Inventor
Yang Ying
Alavattam Sreedhara
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51703416&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR097791(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of AR097791A1 publication Critical patent/AR097791A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Formulaciones farmacéuticas acuosas estables que comprenden un anticuerpo anti-PDL1. Métodos para preparar tales formulaciones y métodos de uso de tales formulaciones. Reivindicación 1: Una formulación farmacéutica acuosa estable, caracterizada porque comprende un anticuerpo monoclonal anti-PDL1 en una concentración de aproximadamente 40 mg/ml a aproximadamente 125 mg/ml, acetato de histidina o acetato de sodio en una concentración de aproximadamente 15 mM a aproximadamente 25 mM, sacarosa en una concentración de aproximadamente 60 mM a aproximadamente 240 mM, polisorbato en una concentración de aproximadamente 0,005% (p/v) a aproximadamente 0,06% (p/v) y un pH de aproximadamente 5,0 a aproximadamente 6,3.
ARP140103581A 2013-09-27 2014-09-26 Formulaciones de anticuerpos anti-pdl1 AR097791A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361883953P 2013-09-27 2013-09-27

Publications (1)

Publication Number Publication Date
AR097791A1 true AR097791A1 (es) 2016-04-13

Family

ID=51703416

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP140103581A AR097791A1 (es) 2013-09-27 2014-09-26 Formulaciones de anticuerpos anti-pdl1
ARP230102359A AR130402A2 (es) 2013-09-27 2023-09-06 Formulaciones de anticuerpos anti-pdl1

Family Applications After (1)

Application Number Title Priority Date Filing Date
ARP230102359A AR130402A2 (es) 2013-09-27 2023-09-06 Formulaciones de anticuerpos anti-pdl1

Country Status (32)

Country Link
US (5) US10875922B2 (es)
EP (3) EP4285928A3 (es)
JP (3) JP6942465B2 (es)
KR (1) KR102331663B1 (es)
CN (1) CN105793288B (es)
AR (2) AR097791A1 (es)
AU (3) AU2014324703C1 (es)
BR (1) BR112016006397B1 (es)
CA (1) CA2925310C (es)
CL (1) CL2016000680A1 (es)
CR (1) CR20160141A (es)
DK (1) DK3049441T3 (es)
EA (2) EA201991715A1 (es)
ES (1) ES2768614T3 (es)
HR (1) HRP20200102T1 (es)
HU (1) HUE047194T2 (es)
IL (3) IL244712B (es)
LT (1) LT3049441T (es)
MA (1) MA38960A1 (es)
MX (3) MX375378B (es)
MY (1) MY175472A (es)
NZ (1) NZ719036A (es)
PE (1) PE20160541A1 (es)
PH (2) PH12016500566A1 (es)
PL (1) PL3049441T3 (es)
PT (1) PT3049441T (es)
RS (1) RS59880B1 (es)
SG (2) SG11201602283UA (es)
SI (1) SI3049441T1 (es)
TW (2) TWI714022B (es)
UA (1) UA122478C2 (es)
WO (1) WO2015048520A1 (es)

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